DegronMD - Q69YQ0(SPECC1L)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T972M	TCGA-06-0152	GBM	TCGA	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.0833
p.T972M	DO11238	GBM	ICGC	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.0833
p.I994V	TCGA-49-AARQ	LUAD	TCGA	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.1944
p.I994V	DO51189	LUAD	ICGC	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.1944
p.P355S	TCGA-CG-5726	STAD	TCGA	PLTSS	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.6752
p.P355S	DO38483	STAD	ICGC	PLTSS	DEG_SPOP_SBC_1	355:359	Mutation altering degron motif	0.6752
p.I994T	TCGA-EO-A22R	UCEC	TCGA	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.1944
p.I994T	DO42713	UCEC	ICGC	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.1944
p.S368F	TCGA-IH-A3EA	SKCM	TCGA	APSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7982
p.S368F	DO37667	SKCM	ICGC	APSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7982
p.T874I	TCGA-IZ-8196	KIRP	TCGA	PPAAAVSPM	DEG_SIAH_1	875:883	Mutation blocking phosphorylation signal	0.75
p.T874I	DO44461	KIRP	ICGC	PPAAAVSPM	DEG_SIAH_1	875:883	Mutation blocking phosphorylation signal	0.75
p.E351K	TCGA-K4-A3WS	BLCA	TCGA	PLTSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.E351K	DO480	BLCA	ICGC	PLTSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.2222
p.P974T	TCGA-KQ-A41R	BLCA	TCGA	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.1389
p.P974T	DO223592	BLCA	ICGC	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.1389
p.S980F	TCGA-VP-A876	PRAD	TCGA	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.3056
p.S980F	DO51380	PRAD	ICGC	SPTASVTPT	DEG_SIAH_1	981:989	Mutation rewiring degron network	0.3056
p.S895T	DO225220	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation altering degron motif	0.6005
p.S895T	DO227719	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation altering degron motif	0.6005
p.S895F	DO225220	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation altering degron motif	0.7982
p.S895F	DO227719	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation altering degron motif	0.7982
p.S889N	DO230326	COCA	ICGC	PPAAAVSPM	DEG_SIAH_1	875:883	Mutation blocking phosphorylation signal	0.6111
p.S889N	DO230326	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation blocking phosphorylation signal	0.7222
p.P897S	DO233117	GACA	ICGC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2778
p.P897S	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.2778
p.R379H	DO233944	GACA	ICGC	APSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.0556
p.A362S	DO231959	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.25
p.A362S	DO231959	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.25
p.A365S	DO228974	LICA	ICGC	APSSS	DEG_SPOP_SBC_1	365:369	Mutation altering degron motif	0.7588
p.Q354H	DO229019	LICA	ICGC	PLTSS	DEG_SPOP_SBC_1	355:359	Mutation rewiring degron network	0.3056
p.P375L	DO220851	MELA	ICGC	APSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1667
p.P375L	SIDM00545	Melanoma	GDSC	APSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1667
p.P375L	ACH-000987	Skin Cancer	CCLE	APSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1667
p.P375L	Mewo	skin	COSMIC	APSSS	DEG_SPOP_SBC_1	365:369	Mutation rewiring degron network	0.1667
p.L898M	SIDM01314	Colorectal Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation rewiring degron network	0.25
p.P869L	SIDM00014	Colorectal Carcinoma	GDSC	PPAAAVSPM	DEG_SIAH_1	875:883	Mutation rewiring degron network	0.1667
p.P869L	LIM1215	large intestine	COSMIC	PPAAAVSPM	DEG_SIAH_1	875:883	Mutation rewiring degron network	0.1667
p.I892V	SIDM01442	Glioma	GDSC	PISTS	DEG_SPOP_SBC_1	891:895	Mutation altering degron motif	0.5965

Kaplan plot for SPECC1L in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SPECC1L

UniProt ID: Q69YQ0

Entrez ID: 23384

Protein name: Cytospin-A (Renal carcinoma antigen NY-REN-22) (Sperm antigen with calponin homology and coiled-coil domains 1-like) (SPECC1-like protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SPECC1L in