DegronMD

Uniprot ID: Q69YQ0

Source protein: Cytospin-A

Source gene: SPECC1L

Class: DEG_SIAH_1

Location: 875:883

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9979

ASA_SCORE: 65.5444

COIL: 0.7197

CONS_SCORE: 0.5192

DSS_SCORE: 0.6603

HELIX: 0.2163

FCONS_SCORE: 1.1219

RIG_SCORE: 0.6228

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T874I	TCGA-IZ-8196	KIRP	TCGA	PPAAAVSPM	DEG_SIAH_1	0.75
p.T874I	DO44461	KIRP	ICGC	PPAAAVSPM	DEG_SIAH_1	0.75
p.S889N	DO230326	COCA	ICGC	PPAAAVSPM	DEG_SIAH_1	0.6111
p.P869L	SIDM00014	Colorectal Carcinoma	GDSC	PPAAAVSPM	DEG_SIAH_1	0.1667
p.P869L	LIM1215	large_intestine	COSMIC	PPAAAVSPM	DEG_SIAH_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q69YQ0	Cytospin-A	DEG_SIAH_1	875:883	PPAAAVSPM	SIAH1,SIAH2,SIAH3	0.9979	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons