DegronMD

Uniprot ID: Q69YQ0

Source protein: Cytospin-A

Source gene: SPECC1L

Class: DEG_SIAH_1

Location: 981:989

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.9974

ASA_SCORE: 83.4778

COIL: 0.9268

CONS_SCORE: 0.5052

DSS_SCORE: 0.6545

HELIX: 0.0358

FCONS_SCORE: 1.028

RIG_SCORE: 0.6178

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T972M	TCGA-06-0152	GBM	TCGA	SPTASVTPT	DEG_SIAH_1	0.0833
p.T972M	DO11238	GBM	ICGC	SPTASVTPT	DEG_SIAH_1	0.0833
p.I994V	TCGA-49-AARQ	LUAD	TCGA	SPTASVTPT	DEG_SIAH_1	0.1944
p.I994V	DO51189	LUAD	ICGC	SPTASVTPT	DEG_SIAH_1	0.1944
p.I994T	TCGA-EO-A22R	UCEC	TCGA	SPTASVTPT	DEG_SIAH_1	0.1944
p.I994T	DO42713	UCEC	ICGC	SPTASVTPT	DEG_SIAH_1	0.1944
p.P974T	TCGA-KQ-A41R	BLCA	TCGA	SPTASVTPT	DEG_SIAH_1	0.1389
p.P974T	DO223592	BLCA	ICGC	SPTASVTPT	DEG_SIAH_1	0.1389
p.S980F	TCGA-VP-A876	PRAD	TCGA	SPTASVTPT	DEG_SIAH_1	0.3056
p.S980F	DO51380	PRAD	ICGC	SPTASVTPT	DEG_SIAH_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q69YQ0	Cytospin-A	DEG_SIAH_1	981:989	SPTASVTPT	SIAH1,SIAH2,SIAH3	0.9974	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons