DegronMD

Uniprot ID: Q69YQ0

Source protein: Cytospin-A

Source gene: SPECC1L

Class: DEG_SPOP_SBC_1

Location: 891:895

E3 ligase: SPOP

DEGRON score: 0.9968

ASA_SCORE: 75.5

COIL: 0.8392

CONS_SCORE: 0.3894

DSS_SCORE: 0.6221

HELIX: 0.0578

FCONS_SCORE: 0.8663

RIG_SCORE: 0.6065

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S895T	DO225220	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6005
p.S895T	DO227719	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6005
p.S895F	DO225220	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.7982
p.S895F	DO227719	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.7982
p.S889N	DO230326	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.7222
p.P897S	DO233117	GACA	ICGC	PISTS	DEG_SPOP_SBC_1	0.2778
p.P897S	SIDM00322	Esophageal Squamous Cell Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.2778
p.L898M	SIDM01314	Colorectal Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.25
p.I892V	SIDM01442	Glioma	GDSC	PISTS	DEG_SPOP_SBC_1	0.5965

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons