DegronMD - O94855(SEC24D)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S125I	TCGA-AP-A051	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.0556
p.S107Y	TCGA-B5-A0JY	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.S107Y	DO43041	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2222
p.G27E	TCGA-DF-A2KU	UCEC	TCGA	PPHY	ITCH	23:26	Mutation rewiring degron network	0.3056
p.G27E	DO223286	UCEC	ICGC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.3056
p.H25Y	TCGA-ET-A25O	THCA	TCGA	PPHY	ITCH	23:26	Mutation altering degron motif	0.6118
p.H25Y	DO38980	THCA	ICGC	PPHY	ITCH	23:26	Mutation altering degron motif	0.6118
p.G5D	TCGA-L5-A4OO	ESCA	TCGA	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.2778
p.P11L	DO233947	GACA	ICGC	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.6471
p.P17T	DO228978	LICA	ICGC	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.2222
p.P17T	DO228978	LICA	ICGC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.1667
p.P17T	DO229025	LICA	ICGC	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.2222
p.P17T	DO229025	LICA	ICGC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.1667
p.P109Q	DO228985	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.2778
p.T35K	DO229015	LICA	ICGC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.0833
p.P11Q	DO229025	LICA	ICGC	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.5924
p.H34Q	DO229026	LICA	ICGC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.1111
p.S115L	DO220899	MELA	ICGC	PISTS	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.7667
p.S106T	DO232761	PBCA	ICGC	PISTS	DEG_SPOP_SBC_1	111:115	Mutation rewiring degron network	0.1944
p.G18R	DO228603	PRAD	ICGC	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.1944
p.G18R	DO228603	PRAD	ICGC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.1944
p.Y29C	SIDM00491	Thyroid Gland Carcinoma	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.Y29C	SIDM00555	Glioblastoma	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.Y29C	SIDM00355	Non-Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.Y29C	SIDM00502	B-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.Y29C	SIDM00359	Colorectal Carcinoma	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.Y29C	SIDM01439	Hepatocellular Carcinoma	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.Y29C	SIDM00169	Head and Neck Carcinoma	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.Y29C	SIDM01685	B-Lymphoblastic Leukemia	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.Y29C	SIDM00164	Biliary Tract Carcinoma	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.25
p.P32S	SIDM00650	Small Cell Lung Carcinoma	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.1667
p.P32S	SIDM01681	Non-Cancerous	GDSC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.1667
p.P32S	ACH-002362	Non-Cancerous	CCLE	PPHY	ITCH	23:26	Mutation rewiring degron network	0.1667
p.P23A	SIDM00929	Chondrosarcoma	GDSC	PPHY	ITCH	23:26	Mutation altering degron motif	0.7503
p.P23A	ACH-000516	Bone Cancer	CCLE	PPHY	ITCH	23:26	Mutation altering degron motif	0.7503
p.P23A	CAL-78	bone	COSMIC	PPHY	ITCH	23:26	Mutation altering degron motif	0.7503
p.D24N	ACH-000112	Leukemia	CCLE	PPHY	ITCH	23:26	Mutation altering degron motif	0.6932
p.D24N	SIG-M5	haematopoietic and lymphoid tissue	COSMIC	PPHY	ITCH	23:26	Mutation altering degron motif	0.6932
p.T111A	ACH-000969	Colon/Colorectal Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	111:115	Mutation altering degron motif	0.7139
p.G10R	ACH-000989	Colon/Colorectal Cancer	CCLE	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.7568
p.G10R	SNU-175	large intestine	COSMIC	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.7568
p.S2N	ACH-001970	Metastasis	CCLE	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation blocking phosphorylation signal	0.6389
p.C18Y	HCC2998	large intestine	COSMIC	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation rewiring degron network	0.1944
p.C18Y	HCC2998	large intestine	COSMIC	PPHY	ITCH	23:26	Mutation rewiring degron network	0.1944
p.I9K	M14	skin	COSMIC	VATPPYS	DEG_SCF_FBW7_1	7:13	Mutation altering degron motif	0.7531

Kaplan plot for SEC24D in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SEC24D

UniProt ID: O94855

Entrez ID: 9871

Protein name: Protein transport protein Sec24D (SEC24-related protein D)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SEC24D in