DegronMD

Uniprot ID: O94855

Source protein: Protein transport protein Sec24D

Source gene: SEC24D

Class: DEG_SCF_FBW7_1

Location: 7:13

E3 ligase: FBXW7

DEGRON score: 0.9896

ASA_SCORE: 87.3

COIL: 0.9631

CONS_SCORE: 0.2596

DSS_SCORE: 0.701

HELIX: 0.0169

FCONS_SCORE: 0.9882

RIG_SCORE: 0.669

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.G5D	TCGA-L5-A4OO	ESCA	TCGA	VATPPYS	DEG_SCF_FBW7_1	0.2778
p.P11L	DO233947	GACA	ICGC	VATPPYS	DEG_SCF_FBW7_1	0.6471
p.P17T	DO228978	LICA	ICGC	VATPPYS	DEG_SCF_FBW7_1	0.2222
p.P17T	DO229025	LICA	ICGC	VATPPYS	DEG_SCF_FBW7_1	0.2222
p.P11Q	DO229025	LICA	ICGC	VATPPYS	DEG_SCF_FBW7_1	0.5924
p.G18R	DO228603	PRAD	ICGC	VATPPYS	DEG_SCF_FBW7_1	0.1944
p.G10R	ACH-000989	Colon/Colorectal Cancer	CCLE	VATPPYS	DEG_SCF_FBW7_1	0.7568
p.G10R	SNU-175	large_intestine	COSMIC	VATPPYS	DEG_SCF_FBW7_1	0.7568
p.S2N	ACH-001970	Metastasis	CCLE	VATPPYS	DEG_SCF_FBW7_1	0.6389
p.C18Y	HCC2998	large_intestine	COSMIC	VATPPYS	DEG_SCF_FBW7_1	0.1944
p.I9K	M14	skin	COSMIC	VATPPYS	DEG_SCF_FBW7_1	0.7531

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SCF_FBW7_1	7:13	VATPPYS	FBXW7	0.9896	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons