DegronMD

Uniprot ID: O94855

Source protein: Protein transport protein Sec24D

Source gene: SEC24D

Class: DEG_SPOP_SBC_1

Location: 111:115

E3 ligase: SPOP

DEGRON score: 0.9483

ASA_SCORE: 82.2

COIL: 0.953

CONS_SCORE: 0.264

DSS_SCORE: 0.5819

HELIX: 0.023

FCONS_SCORE: 0.9645

RIG_SCORE: 0.6456

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S125I	TCGA-AP-A051	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.0556
p.S107Y	TCGA-B5-A0JY	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.2222
p.S107Y	DO43041	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.2222
p.P109Q	DO228985	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	0.2778
p.S115L	DO220899	MELA	ICGC	PISTS	DEG_SPOP_SBC_1	0.7667
p.S106T	DO232761	PBCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.1944
p.T111A	ACH-000969	Colon/Colorectal Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.7139

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons