DegronMD

Uniprot ID: Q13428

Source protein: Treacle protein

Source gene: TCOF1

Class: DEG_SPOP_SBC_1

Location: 81:85

E3 ligase: SPOP

DEGRON score: 0.9924

ASA_SCORE: 92.6

COIL: 0.9378

CONS_SCORE: 0.8859

DSS_SCORE: 0.6896

HELIX: 0.0308

FCONS_SCORE: 1.2022

RIG_SCORE: 0.5971

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R77L	TCGA-CJ-4899	KIRC	TCGA	PISTS	DEG_SPOP_SBC_1	0.2222
p.R77L	DO16233	KIRC	ICGC	PISTS	DEG_SPOP_SBC_1	0.2222
p.R77C	TCGA-E6-A1LX	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.2222
p.R77C	DO42304	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.2222
p.R77C	DO41020	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.2222
p.E89K	TCGA-EE-A2A1	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	0.2222
p.E89K	DO38045	SKCM	ICGC	PISTS	DEG_SPOP_SBC_1	0.2222
p.E91K	DO227916	BRCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.1667
p.S88L	DO222762	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6944
p.V78L	DO229015	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	0.25
p.T76P	DO228253	MALY	ICGC	PISTS	DEG_SPOP_SBC_1	0.1944
p.S85L	SIDM00040	Gastric Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.8778
p.S85L	ACH-002202	Gastric Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.8778
p.S85L	TMK-1	stomach	COSMIC	PISTS	DEG_SPOP_SBC_1	0.8778
p.R77H	SIDM00819	Kidney Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.2222
p.R77H	ACH-002189	Kidney Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.2222
p.R77H	RCC-FG2	kidney	COSMIC	PISTS	DEG_SPOP_SBC_1	0.2222

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons