DegronMD - Q15762(CD226)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D315N	TCGA-3N-A9WD	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1111
p.D315N	DO51235	SKCM	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1111
p.T310S	TCGA-70-6723	LUSC	TCGA	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.25
p.A296V	TCGA-A5-A0G2	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1389
p.N298T	TCGA-AX-A05Z	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1944
p.N298T	DO40884	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1944
p.T317S	TCGA-CN-6021	HNSC	TCGA	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.0556
p.P303L	TCGA-EE-A2ML	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.7582
p.S307G	DO229010	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.6993
p.S307G	DO229013	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.6993
p.S307G	DO229016	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.6993
p.S307G	DO229003	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.6993
p.S307G	DO229005	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.6993
p.S307G	DO229047	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.6993
p.I304V	DO228196	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.5965
p.P297A	SIDM01081	Oral Cavity Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1667
p.P297A	ACH-000238	Head and Neck Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1667
p.P297A	SCC-4	upper aerodigestive tract	COSMIC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.1667
p.S302I	SIDM00217	Colorectal Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.3056
p.S302I	ACH-000999	Colon/Colorectal Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.3056
p.S302I	SNU-1040	large intestine	COSMIC	PISTS	DEG_SPOP_SBC_1	303:307	Mutation rewiring degron network	0.3056
p.S307T	ACH-001853	Bile Duct Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	303:307	Mutation altering degron motif	0.6005

Kaplan plot for CD226 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CD226

UniProt ID: Q15762

Entrez ID: 10666

Protein name: CD226 antigen (DNAX accessory molecule 1) (DNAM-1) (CD antigen CD226)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CD226 in