DegronMD

Uniprot ID: Q15762

Source protein: CD226 antigen

Source gene: CD226

Class: DEG_SPOP_SBC_1

Location: 303:307

E3 ligase: SPOP

DEGRON score: 0.9768

ASA_SCORE: 85.68

COIL: 0.9126

CONS_SCORE: 0.3715

DSS_SCORE: 0.7214

HELIX: 0.0646

FCONS_SCORE: 1.1147

RIG_SCORE: 0.6333

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D315N	TCGA-3N-A9WD	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	0.1111
p.D315N	DO51235	SKCM	ICGC	PISTS	DEG_SPOP_SBC_1	0.1111
p.T310S	TCGA-70-6723	LUSC	TCGA	PISTS	DEG_SPOP_SBC_1	0.25
p.A296V	TCGA-A5-A0G2	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.1389
p.N298T	TCGA-AX-A05Z	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.1944
p.N298T	DO40884	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.1944
p.T317S	TCGA-CN-6021	HNSC	TCGA	PISTS	DEG_SPOP_SBC_1	0.0556
p.P303L	TCGA-EE-A2ML	SKCM	TCGA	PISTS	DEG_SPOP_SBC_1	0.7582
p.S307G	DO229010	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6993
p.S307G	DO229013	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6993
p.S307G	DO229016	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6993
p.S307G	DO229003	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6993
p.S307G	DO229005	COCA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6993
p.S307G	DO229047	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	0.6993
p.I304V	DO228196	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	0.5965
p.P297A	SIDM01081	Oral Cavity Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.1667
p.P297A	ACH-000238	Head and Neck Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.1667
p.P297A	SCC-4	upper_aerodigestive_tract	COSMIC	PISTS	DEG_SPOP_SBC_1	0.1667
p.S302I	SIDM00217	Colorectal Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.3056
p.S302I	ACH-000999	Colon/Colorectal Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.3056
p.S302I	SNU-1040	large_intestine	COSMIC	PISTS	DEG_SPOP_SBC_1	0.3056
p.S307T	ACH-001853	Bile Duct Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.6005

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons