DegronMD

Uniprot ID: P33981

Source protein: Dual specificity protein kinase TTK

Source gene: TTK

Class: DEG_SPOP_SBC_1

Location: 438:442

E3 ligase: SPOP

DEGRON score: 0.9975

ASA_SCORE: 83.36

COIL: 0.8796

CONS_SCORE: 0.3042

DSS_SCORE: 0.4036

HELIX: 0.1096

FCONS_SCORE: 1.0057

RIG_SCORE: 0.6869

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S449Y	TCGA-D1-A17Q	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.1389
p.S449Y	TCGA-E6-A1LX	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.1389
p.K451E	DO233155	GACA	ICGC	PISTS	DEG_SPOP_SBC_1	0.0833
p.S448Y	DO41020	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.6111
p.S448Y	DO41903	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.6111
p.P438S	SIDM01175	Other Sarcomas	GDSC	PISTS	DEG_SPOP_SBC_1	0.6752
p.P438S	SW684	soft_tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	0.6752
p.P437S	ACH-002309	Sarcoma	CCLE	PISTS	DEG_SPOP_SBC_1	0.3056
p.P437S	SW684	soft_tissue	COSMIC	PISTS	DEG_SPOP_SBC_1	0.3056

Drug responses associated with TTK mutations

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00155	HNSC\|head_and_neck	p.Y554H (No)	GDSC	MPS-1-IN-1	26.0345
SIDM00155	HNSC\|head_and_neck	p.Y554H (No)	GDSC	TTK_3146	6.6182
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.G855R (No)	GDSC	MPS-1-IN-1	6.3135
SIDM00961	UNCLASSIFIED\|ewings_sarcoma	p.G855R (No)	GDSC	TTK_3146	14.5605
SIDM00889	CESC\|cervix	p.G855fs*38 (No)	GDSC	MPS-1-IN-1	22.1569
SIDM00889	CESC\|cervix	p.G855fs*38 (No)	GDSC	TTK_3146	7.7341
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.S162I (No)	GDSC	MPS-1-IN-1	73.7542
SIDM00345	UNCLASSIFIED\|lung_NSCLC_large_cell	p.S162I (No)	GDSC	TTK_3146	81.1916
SIDM00592	HNSC\|head_and_neck	p.P469L (No)	GDSC	MPS-1-IN-1	62.657
SIDM00592	HNSC\|head_and_neck	p.P469L (No)	GDSC	TTK_3146	6.6959
SIDM00839	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	123.4717
SIDM00839	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	TTK_3146	8.33
SIDM00839	COREAD\|large_intestine	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	123.4717
SIDM00839	COREAD\|large_intestine	p.K857fs*36 (No)	GDSC	TTK_3146	8.33
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	12.644
SIDM00451	ALL\|lymphoblastic_T_cell_leukaemia	p.K857fs*36 (No)	GDSC	TTK_3146	49.7763
SIDM00498	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	67.475
SIDM00498	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	TTK_3146	17.9645
SIDM00945	COREAD\|large_intestine	p.Q193fs*33 (No)	GDSC	TTK_3146	15.6342
SIDM00945	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	TTK_3146	15.6342
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.N704S (No)	GDSC	MPS-1-IN-1	14.9793
SIDM00433	ALL\|lymphoblastic_T_cell_leukaemia	p.N704S (No)	GDSC	TTK_3146	8.4857
SIDM01045	UCEC\|endometrium	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	24.7197
SIDM01045	UCEC\|endometrium	p.R854fs*39 (No)	GDSC	TTK_3146	23.9849
SIDM01051	UNCLASSIFIED\|ovary	p.K192fs*18 (No)	GDSC	MPS-1-IN-1	21.6044
SIDM01051	UNCLASSIFIED\|ovary	p.K192fs*18 (No)	GDSC	TTK_3146	7.4282
SIDM01051	UNCLASSIFIED\|ovary	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	21.6044
SIDM01051	UNCLASSIFIED\|ovary	p.R854fs*10 (No)	GDSC	TTK_3146	7.4282
SIDM00208	LGG\|glioma	p.S37R (No)	GDSC	MPS-1-IN-1	263.748
SIDM00208	LGG\|glioma	p.S37R (No)	GDSC	TTK_3146	55.9512
SIDM00683	PRAD\|prostate	p.S76G (No)	GDSC	MPS-1-IN-1	58.4126
SIDM00683	PRAD\|prostate	p.S76G (No)	GDSC	TTK_3146	23.8314
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	9.2845
SIDM00388	UNCLASSIFIED\|B_cell_leukemia	p.K857fs*36 (No)	GDSC	TTK_3146	5.7709
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	13.8361
SIDM00654	SCLC\|lung_small_cell_carcinoma	p.R854fs*39 (No)	GDSC	TTK_3146	10.4458
SIDM00837	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	9.8941
SIDM00837	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	TTK_3146	5.2908
SIDM00781	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	64.3824
SIDM00781	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	TTK_3146	8.1584
SIDM00334	UCEC\|endometrium	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	231.8726
SIDM00334	UCEC\|endometrium	p.R854fs*10 (No)	GDSC	TTK_3146	12.6068
SIDM00669	PAAD\|pancreas	p.L609F (No)	GDSC	MPS-1-IN-1	22.6311
SIDM00669	PAAD\|pancreas	p.L609F (No)	GDSC	TTK_3146	14.7947
SIDM00537	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	17.8433
SIDM00537	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	TTK_3146	17.5236
SIDM01174	CESC\|cervix	p.S699F (No)	GDSC	MPS-1-IN-1	404.6474
SIDM01174	CESC\|cervix	p.S699F (No)	GDSC	TTK_3146	10.2843
SIDM01051	UNCLASSIFIED\|ovary	p.L499F (No)	GDSC	MPS-1-IN-1	21.6044
SIDM01051	UNCLASSIFIED\|ovary	p.L499F (No)	GDSC	TTK_3146	7.4282
SIDM00742	LUAD\|lung_NSCLC_adenocarcinoma	p.Y811C (No)	GDSC	MPS-1-IN-1	564.4112
SIDM00145	ALL\|lymphoblastic_leukemia	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	8.6417
SIDM00145	ALL\|lymphoblastic_leukemia	p.R854fs*39 (No)	GDSC	TTK_3146	5.6383
SIDM00499	PRAD\|prostate	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	5.6749
SIDM00499	PRAD\|prostate	p.R854fs*39 (No)	GDSC	TTK_3146	10.8525
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	5.4727
SIDM00429	UNCLASSIFIED\|B_cell_leukemia	p.R854fs*39 (No)	GDSC	TTK_3146	3.7106
SIDM00320	LUAD\|lung_NSCLC_adenocarcinoma	p.D608H (No)	GDSC	TTK_3146	12.1851
SIDM00958	LCML\|chronic_myeloid_leukaemia	p.R854fs*11 (No)	GDSC	TTK_3146	12.4078
SIDM00819	KIRC\|kidney	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	157.3903
SIDM00819	KIRC\|kidney	p.R854fs*39 (No)	GDSC	TTK_3146	26.3473
SIDM01197	COREAD\|large_intestine	p.P469L (No)	GDSC	MPS-1-IN-1	101.16
SIDM01197	COREAD\|large_intestine	p.P469L (No)	GDSC	TTK_3146	35.6547
SIDM00151	OV\|ovary	p.K192fs*18 (No)	GDSC	TTK_3146	8.9284
SIDM00151	OV\|ovary	p.R854fs*39 (No)	GDSC	TTK_3146	8.9284
SIDM00373	UCEC\|endometrium	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	25.0049
SIDM00373	UCEC\|endometrium	p.R854fs*39 (No)	GDSC	TTK_3146	6.292
SIDM01259	ALL\|lymphoblastic_leukemia	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	11.8586
SIDM01259	ALL\|lymphoblastic_leukemia	p.R854fs*39 (No)	GDSC	TTK_3146	11.7293
SIDM00431	ALL\|lymphoblastic_T_cell_leukaemia	p.R624C (No)	GDSC	TTK_3146	4.5008
SIDM00933	BRCA\|breast	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	173.2289
SIDM00933	BRCA\|breast	p.K857fs*36 (No)	GDSC	TTK_3146	1.8689
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.Y726C (No)	GDSC	MPS-1-IN-1	16.9282
SIDM00793	UNCLASSIFIED\|Burkitt_lymphoma	p.Y726C (No)	GDSC	TTK_3146	14.5274
SIDM00251	STAD\|stomach	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	23.4756
SIDM00251	STAD\|stomach	p.R854fs*39 (No)	GDSC	TTK_3146	24.0233
SIDM01045	UCEC\|endometrium	p.V77A (No)	GDSC	MPS-1-IN-1	24.7197
SIDM01045	UCEC\|endometrium	p.V77A (No)	GDSC	TTK_3146	23.9849
SIDM01045	UCEC\|endometrium	p.Q736R (No)	GDSC	MPS-1-IN-1	24.7197
SIDM01045	UCEC\|endometrium	p.Q736R (No)	GDSC	TTK_3146	23.9849
SIDM00602	STAD\|stomach	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	43.0273
SIDM00602	STAD\|stomach	p.R854fs*39 (No)	GDSC	TTK_3146	12.7116
SIDM00568	STAD\|stomach	p.P469L (No)	GDSC	MPS-1-IN-1	82.4571
SIDM00568	STAD\|stomach	p.P469L (No)	GDSC	TTK_3146	14.1673
SIDM00425	OV\|ovary	p.S511C (No)	GDSC	MPS-1-IN-1	94.6282
SIDM00425	OV\|ovary	p.S511C (No)	GDSC	TTK_3146	13.3033
SIDM00783	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	10.5644
SIDM00783	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	TTK_3146	2.9021
SIDM00231	KIRC\|kidney	p.R172H (No)	GDSC	TTK_3146	13.332
SIDM00596	UCEC\|endometrium	p.S455N (No)	GDSC	MPS-1-IN-1	198.7457
SIDM00596	UCEC\|endometrium	p.S455N (No)	GDSC	TTK_3146	21.0442
SIDM00282	COREAD\|large_intestine	p.K696E (No)	GDSC	MPS-1-IN-1	41.7365
SIDM00282	COREAD\|large_intestine	p.K696E (No)	GDSC	TTK_3146	7.8098
SIDM01088	UNCLASSIFIED\|endometrium	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	9.8641
SIDM01088	UNCLASSIFIED\|endometrium	p.R854fs*39 (No)	GDSC	TTK_3146	8.0027
SIDM00150	COREAD\|large_intestine	p.S228R (No)	GDSC	MPS-1-IN-1	15.9439
SIDM00150	COREAD\|large_intestine	p.S228R (No)	GDSC	TTK_3146	103.0315
SIDM00216	COREAD\|large_intestine	p.E851fs*42 (No)	GDSC	MPS-1-IN-1	5.9412
SIDM00660	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	11.0068
SIDM00660	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	TTK_3146	18.461
SIDM00238	OV\|ovary	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	110.2407
SIDM00238	OV\|ovary	p.K857fs*36 (No)	GDSC	TTK_3146	21.587
SIDM00886	DLBC\|B_cell_lymphoma	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	21.9339
SIDM00886	DLBC\|B_cell_lymphoma	p.K857fs*36 (No)	GDSC	TTK_3146	4.9595
SIDM00878	BRCA\|breast	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	231.0051
SIDM00878	BRCA\|breast	p.R854fs*39 (No)	GDSC	TTK_3146	20.7437
SIDM00150	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	15.9439
SIDM00150	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	TTK_3146	103.0315
SIDM01090	COREAD\|large_intestine	p.S162fs*9 (No)	GDSC	MPS-1-IN-1	12.2405
SIDM01090	COREAD\|large_intestine	p.S162fs*9 (No)	GDSC	TTK_3146	6.3167
SIDM01090	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	12.2405
SIDM01090	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	TTK_3146	6.3167
SIDM01146	STAD\|stomach	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	9.543
SIDM01146	STAD\|stomach	p.R854fs*39 (No)	GDSC	TTK_3146	89.0575
SIDM01146	STAD\|stomach	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	9.543
SIDM01146	STAD\|stomach	p.R854fs*10 (No)	GDSC	TTK_3146	89.0575
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P438S (Yes)	GDSC	MPS-1-IN-1	837.7
SIDM01175	UNCLASSIFIED\|fibrosarcoma	p.P438S (Yes)	GDSC	TTK_3146	228.2917
SIDM00680	COREAD\|large_intestine	p.K192fs*18 (No)	GDSC	MPS-1-IN-1	379.3761
SIDM00680	COREAD\|large_intestine	p.K192fs*18 (No)	GDSC	TTK_3146	17.4439
SIDM00487	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	MPS-1-IN-1	34.8374
SIDM00487	COREAD\|large_intestine	p.R854fs*10 (No)	GDSC	TTK_3146	17.4522
SIDM00217	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	24.5634
SIDM00217	COREAD\|large_intestine	p.R854fs*39 (No)	GDSC	TTK_3146	123.2552
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	19.5174
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.R854fs*39 (No)	GDSC	TTK_3146	70.5126
SIDM00359	COREAD\|large_intestine	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	366.0131
SIDM00359	COREAD\|large_intestine	p.K857fs*36 (No)	GDSC	TTK_3146	8.5364
SIDM00114	MESO\|mesothelioma	p.E337K (No)	GDSC	MPS-1-IN-1	605.361
SIDM00114	MESO\|mesothelioma	p.E337K (No)	GDSC	TTK_3146	24.3648
SIDM00652	SCLC\|lung_small_cell_carcinoma	p.P275T (No)	GDSC	TTK_3146	24.2675
SIDM00980	STAD\|stomach	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	18.4489
SIDM00980	STAD\|stomach	p.R854fs*39 (No)	GDSC	TTK_3146	6.4809
SIDM00120	PRAD\|prostate	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	102.9541
SIDM00120	PRAD\|prostate	p.R854fs*39 (No)	GDSC	TTK_3146	19.6806
SIDM00834	COREAD\|large_intestine	p.S389F (No)	GDSC	MPS-1-IN-1	1469.6918
SIDM00834	COREAD\|large_intestine	p.S389F (No)	GDSC	TTK_3146	90.4781
SIDM00572	STAD\|stomach	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	80.5141
SIDM00572	STAD\|stomach	p.K857fs*36 (No)	GDSC	TTK_3146	7.7747
SIDM00054	PAAD\|pancreas	p.P469L (No)	GDSC	MPS-1-IN-1	140.7131
SIDM00054	PAAD\|pancreas	p.P469L (No)	GDSC	TTK_3146	8.4781
SIDM00364	ALL\|lymphoblastic_leukemia	p.S162fs*2 (No)	GDSC	MPS-1-IN-1	7.9666
SIDM00364	ALL\|lymphoblastic_leukemia	p.S162fs*2 (No)	GDSC	TTK_3146	4.1167
SIDM00333	UCEC\|endometrium	p.R854fs*39 (No)	GDSC	MPS-1-IN-1	88.9609
SIDM00333	UCEC\|endometrium	p.R854fs*39 (No)	GDSC	TTK_3146	12.1614
SIDM00193	COREAD\|large_intestine	p.K40N (No)	GDSC	MPS-1-IN-1	524.2554
SIDM00193	COREAD\|large_intestine	p.K40N (No)	GDSC	TTK_3146	78.963
SIDM00118	COREAD\|large_intestine	p.F540L (No)	GDSC	MPS-1-IN-1	56.0402
SIDM00118	COREAD\|large_intestine	p.F540L (No)	GDSC	TTK_3146	10.2418
SIDM00661	DLBC\|B_cell_lymphoma	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	48.654
SIDM00661	DLBC\|B_cell_lymphoma	p.K857fs*36 (No)	GDSC	TTK_3146	20.8907
SIDM00596	UCEC\|endometrium	p.K857fs*36 (No)	GDSC	MPS-1-IN-1	198.7457
SIDM00596	UCEC\|endometrium	p.K857fs*36 (No)	GDSC	TTK_3146	21.0442

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PISTS

Degron related mutations and impact score

Drug responses associated with TTK mutations

All proteins holding degron of PISTS