DegronMD

Uniprot ID: Q9C0F0

Source protein: Putative Polycomb group protein ASXL3

Source gene: ASXL3

Class: DEG_SPOP_SBC_1

Location: 682:686

E3 ligase: SPOP

DEGRON score: 0.7746

ASA_SCORE: 88.12

COIL: 0.9514

CONS_SCORE: 0.4458

DSS_SCORE: 0.4906

HELIX: 0.0164

FCONS_SCORE: 0.9796

RIG_SCORE: 0.6561

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.F672L	TCGA-2H-A9GL	ESCA	TCGA	PISTS	DEG_SPOP_SBC_1	0.0556
p.S684Y	TCGA-44-2659	LUAD	TCGA	PISTS	DEG_SPOP_SBC_1	0.712
p.S684Y	DO23744	LUAD	ICGC	PISTS	DEG_SPOP_SBC_1	0.712
p.E679D	TCGA-AX-A0J0	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	0.25
p.E679D	DO41133	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	0.25
p.P682S	TCGA-VS-A8EH	CESC	TCGA	PISTS	DEG_SPOP_SBC_1	0.6752
p.P682S	DO51620	CESC	ICGC	PISTS	DEG_SPOP_SBC_1	0.6752
p.A692S	DO229037	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	0.1667
p.S686L	SIDM00837	Colorectal Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	0.7667
p.S686L	ACH-000958	Colon/Colorectal Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	0.7667
p.S686L	SW48	large_intestine	COSMIC	PISTS	DEG_SPOP_SBC_1	0.7667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94855	Protein transport protein Sec24D	DEG_SPOP_SBC_1	111:115	PISTS	SPOP	0.9483	More...
P33981	Dual specificity protein kinase TTK	DEG_SPOP_SBC_1	438:442	PISTS	SPOP	0.9975	More...
Q13428	Treacle protein	DEG_SPOP_SBC_1	81:85	PISTS	SPOP	0.9924	More...
Q15762	CD226 antigen	DEG_SPOP_SBC_1	303:307	PISTS	SPOP	0.9768	More...
Q69YQ0	Cytospin-A	DEG_SPOP_SBC_1	891:895	PISTS	SPOP	0.9968	More...
Q6WKZ4	Rab11 family-interacting protein 1	DEG_SPOP_SBC_1	605:609	PISTS	SPOP	0.9332	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	682:686	PISTS	SPOP	0.7746	More...
Q96BN6	Primary cilium assembly protein FAM149B1	DEG_SPOP_SBC_1	428:432	PISTS	SPOP	0.9122	More...
Q9Y5G3	Protocadherin gamma-B1	DEG_SPOP_SBC_1	282:286	PISTS	SPOP	0.9253	More...
Q96P64	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 4	DEG_SPOP_SBC_1	331:335	PISTS	SPOP	0.9932	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons