DegronMD - Q9C0F0(ASXL3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.N377K	TCGA-05-4382	LUAD	TCGA	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222
p.N377K	DO24900	LUAD	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2222
p.F672L	TCGA-2H-A9GL	ESCA	TCGA	PISTS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.0556
p.T185I	TCGA-2W-A8YY	CESC	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.7078
p.T185I	TCGA-B5-A3FA	UCEC	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.7078
p.T185I	DO223732	CESC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.7078
p.T185I	DO52402	UCEC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.7078
p.S1213F	TCGA-3N-A9WC	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2222
p.S1213F	DO51234	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2222
p.E510D	TCGA-43-8118	LUSC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1944
p.E510D	DO45471	LUSC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1944
p.S684Y	TCGA-44-2659	LUAD	TCGA	PISTS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.712
p.S684Y	DO23744	LUAD	ICGC	PISTS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.712
p.R1036L	TCGA-44-6777	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.3056
p.R1036L	DO23645	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.3056
p.R1036L	SIDM00227	Neuroblastoma	GDSC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.3056
p.E1718K	TCGA-4Z-AA80	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2222
p.E1718K	TCGA-BH-A0B6	BRCA	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2222
p.E1718K	DO218986	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2222
p.E1718K	DO2641	BRCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2222
p.E1718K	DO224750	PACA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2222
p.N1048K	TCGA-55-6985	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1389
p.N1048K	DO25659	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1389
p.S1331R	TCGA-55-7283	LUAD	TCGA	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.3056
p.S1331R	DO23606	LUAD	ICGC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.3056
p.S1714R	TCGA-55-7815	LUAD	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation altering degron motif	0.7427
p.S1714R	DO24537	LUAD	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation altering degron motif	0.7427
p.M1229K	TCGA-55-8506	LUAD	TCGA	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.1111
p.M1229K	DO45390	LUAD	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.1111
p.T374S	TCGA-56-8305	LUSC	TCGA	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.T374S	DO223725	LUSC	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.T1039S	TCGA-80-5607	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.6005
p.T1039S	DO25957	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.6005
p.E888V	TCGA-A5-A0G1	UCEC	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.7693
p.E888V	DO42472	UCEC	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.7693
p.G1046R	TCGA-A5-A0G2	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1944
p.G1046R	DO41235	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1944
p.S196L	TCGA-AA-3864	COAD	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1111
p.S196L	DO8490	COAD	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1111
p.S196L	DO228963	LICA	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1111
p.L1324Q	TCGA-AG-3890	READ	TCGA	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.1111
p.L1324Q	DO36431	READ	ICGC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.1111
p.H552N	TCGA-AG-A002	READ	TCGA	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.25
p.L1350S	TCGA-AJ-A3EL	UCEC	TCGA	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.1111
p.L1350S	DO41542	UCEC	ICGC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.1111
p.E896V	TCGA-AJ-A3IA	UCEC	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1111
p.E896V	DO43082	UCEC	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1111
p.S549Y	TCGA-AJ-A5DW	UCEC	TCGA	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.712
p.S549Y	DO50075	UCEC	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.712
p.S549Y	SIDM00118	Colorectal Carcinoma	GDSC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.712
p.S549Y	ACH-001081	Colon/Colorectal Cancer	CCLE	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.712
p.S549Y	HCC2998	large intestine	COSMIC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation altering degron motif	0.712
p.E873K	TCGA-AP-A051	UCEC	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0556
p.E873K	TCGA-L9-A8F4	LUAD	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0556
p.E873K	DO49876	LUAD	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0556
p.E873K	DO229229	THCA	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0556
p.E873K	DO42673	UCEC	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0556
p.A1330D	TCGA-AP-A059	UCEC	TCGA	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.2778
p.A1330D	DO41361	UCEC	ICGC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.2778
p.E1214D	TCGA-AP-A1E0	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.25
p.E1214D	DO43154	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.25
p.E679D	TCGA-AX-A0J0	UCEC	TCGA	PISTS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.25
p.E679D	DO41133	UCEC	ICGC	PISTS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.25
p.V503G	TCGA-AX-A2HC	UCEC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.7532
p.V503G	DO41572	UCEC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.7532
p.S385Y	TCGA-B5-A0JY	UCEC	TCGA	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.712
p.S385Y	TCGA-CA-6717	COAD	TCGA	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.712
p.S385Y	DO8264	COAD	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.712
p.S385Y	DO43041	UCEC	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.712
p.D507Y	TCGA-B5-A11E	UCEC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.2778
p.D507Y	DO41644	UCEC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.2778
p.D535N	TCGA-BA-4076	HNSC	TCGA	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.0556
p.D535N	TCGA-EE-A29E	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.0556
p.D535N	DO14502	HNSC	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.0556
p.D535N	DO37831	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.0556
p.S1713L	TCGA-BF-A5EQ	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation altering degron motif	0.7667
p.S1713L	DO219452	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation altering degron motif	0.7667
p.G1050R	TCGA-BK-A6W3	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.0833
p.G1050R	DO50076	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.0833
p.E1717A	TCGA-BP-4976	KIRC	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.25
p.E1717A	DO17492	KIRC	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.25
p.P1228S	TCGA-BR-4201	STAD	TCGA	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.1389
p.P1228S	DO38707	STAD	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.1389
p.E538D	TCGA-BR-4256	STAD	TCGA	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1389
p.E538D	DO38743	STAD	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1389
p.G1045D	TCGA-BS-A0U8	UCEC	TCGA	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.2222
p.G1045D	DO41380	UCEC	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.2222
p.S1221C	TCGA-C5-A1BM	CESC	TCGA	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.7541
p.S1221C	DO49007	CESC	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.7541
p.I1216M	TCGA-CA-6718	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.3056
p.I1216M	DO7801	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.3056
p.Q1703H	TCGA-CG-5721	STAD	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1389
p.Q1703H	TCGA-EO-A3B0	UCEC	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1389
p.Q1703H	DO50342	ESAD	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1389
p.Q1703H	DO234449	ESAD	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1389
p.Q1703H	DO38192	STAD	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1389
p.Q1703H	DO219773	UCEC	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1389
p.D891N	TCGA-CR-5248	HNSC	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.25
p.D891N	DO14694	HNSC	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.25
p.E882K	TCGA-D3-A1Q8	SKCM	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.3056
p.E882K	TCGA-EB-A41A	SKCM	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.3056
p.E882K	DO37429	SKCM	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.3056
p.E882K	DO37446	SKCM	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.3056
p.S1031F	TCGA-D3-A51T	SKCM	TCGA	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.S1031F	DO47389	SKCM	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.1667
p.M505I	TCGA-D3-A8GQ	SKCM	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.6507
p.M505I	DO51246	SKCM	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.6507
p.T484P	TCGA-D8-A27H	BRCA	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1111
p.T484P	DO1249	BRCA	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1111
p.V1209E	TCGA-DD-AADA	LIHC	TCGA	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.1111
p.V1209E	DO52227	LIHC	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.1111
p.P898S	TCGA-DU-6392	LGG	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0556
p.P898S	DO22237	LGG	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.0556
p.M1708I	TCGA-E7-A7DU	BLCA	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708I	TCGA-FW-A3R5	SKCM	TCGA	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708I	DO219016	BLCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708I	DO222572	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708I	DO37406	SKCM	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M505L	TCGA-EB-A97M	SKCM	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.5999
p.M505L	DO50298	SKCM	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.5999
p.H552Y	TCGA-EE-A29E	SKCM	TCGA	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.25
p.H552Y	DO37831	SKCM	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.25
p.S1218L	TCGA-EE-A2GL	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6556
p.S1218L	DO229456	SKCA	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6556
p.S1218L	DO37434	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6556
p.E496K	TCGA-ER-A19F	SKCM	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.591
p.E496K	DO37679	SKCM	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.591
p.Q193K	TCGA-FA-A82F	DLBC	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.Q193K	DO219891	DLBC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.S386L	TCGA-FR-A7U9	SKCM	TCGA	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.3056
p.S386L	DO48546	SKCM	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.3056
p.L883F	TCGA-FS-A1ZF	SKCM	TCGA	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.587
p.L883F	DO38039	SKCM	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation altering degron motif	0.587
p.S395C	TCGA-GD-A2C5	BLCA	TCGA	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.S395C	DO496	BLCA	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.E538Q	TCGA-GV-A6ZA	BLCA	TCGA	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1389
p.E538Q	DO49776	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1389
p.L512S	TCGA-NC-A5HO	LUSC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1389
p.L512S	DO219197	LUSC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1389
p.S1027C	TCGA-NJ-A4YI	LUAD	TCGA	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation blocking phosphorylation signal	0.5
p.S1027C	DO218942	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation blocking phosphorylation signal	0.5
p.M173I	TCGA-OL-A5RZ	BRCA	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1389
p.M173I	TCGA-OR-A5LJ	ACC	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1389
p.M173I	DO44228	BRCA	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1389
p.G391C	TCGA-QK-A6VC	HNSC	TCGA	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1667
p.G391C	DO219056	HNSC	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1667
p.G388W	TCGA-QK-A8Z7	HNSC	TCGA	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.25
p.G388W	DO52096	HNSC	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.25
p.S542C	TCGA-SY-A9G5	BLCA	TCGA	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.25
p.S542C	DO51906	BLCA	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.25
p.S482I	TCGA-UT-A97Y	MESO	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.0556
p.P682S	TCGA-VS-A8EH	CESC	TCGA	PISTS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.6752
p.P682S	DO51620	CESC	ICGC	PISTS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.6752
p.M504I	TCGA-Z2-A8RT	SKCM	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.6507
p.M504I	DO51301	SKCM	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.6507
p.V503L	TCGA-ZJ-AB0H	CESC	TCGA	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.5654
p.V503L	DO219760	CESC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.5654
p.Q536K	DO228331	BRCA	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.0833
p.T1220P	DO222941	BTCA	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.7031
p.M1708V	DO229010	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708V	DO229013	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708V	DO229016	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708V	DO229003	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708V	DO229005	COCA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.M1708V	DO229505	LAML	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.2778
p.C387F	DO233230	GACA	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.2778
p.P880R	DO233214	GACA	ICGC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.25
p.S383R	DO233874	GACA	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.7427
p.N1332D	DO233867	GACA	ICGC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.5821
p.D555Y	DO228938	LICA	ICGC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1667
p.V182F	DO229028	LICA	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.5957
p.E1034D	DO229031	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.25
p.A692S	DO229037	LICA	ICGC	PISTS	DEG_SPOP_SBC_1	682:686	Mutation rewiring degron network	0.1667
p.A1051S	DO229006	LICA	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.0556
p.K1215Q	DO50824	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2778
p.I515V	DO23108	LINC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.0556
p.M174T	DO231732	LINC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1667
p.S1040I	DO25189	LUAD	ICGC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7341
p.G170V	DO231047	LUSC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.0556
p.E1223A	DO228824	MALY	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2778
p.T1712P	DO220900	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation altering degron motif	0.7031
p.E1223K	DO222363	MELA	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2778
p.S1711F	DO222868	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation altering degron motif	0.6871
p.G380R	DO222843	MELA	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.3056
p.P1715F	DO222843	MELA	ICGC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.3056
p.S486F	DO36556	READ	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1667
p.R181C	DO229462	SKCA	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation altering degron motif	0.8301
p.S395F	DO218874	SKCA	ICGC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.0556
p.E1223D	DO227688	SKCA	ICGC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2778
p.E488K	DO41398	UCEC	ICGC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.2222
p.T1336P	SIDM01302	Esophageal Carcinoma	GDSC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.5919
p.L392F	SIDM00545	Melanoma	GDSC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.L392F	ACH-000987	Skin Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.L392F	Mewo	skin	COSMIC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.S1044G	SIDM00545	Melanoma	GDSC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.25
p.S1044G	SIDM00751	Non-Small Cell Lung Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.25
p.S1044G	SIDM00490	Glioma	GDSC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation rewiring degron network	0.25
p.S1213T	SIDM00845	Burkitt's Lymphoma	GDSC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation rewiring degron network	0.2222
p.Q193L	SIDM00113	Kidney Carcinoma	GDSC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.Q193L	TK10	kidney	COSMIC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.1944
p.S1221T	SIDM00506	Small Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6005
p.S1221T	ACH-000508	Lung Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6005
p.S1221T	COR-L88	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	1217:1221	Mutation altering degron motif	0.6005
p.Y1338F	SIDM00932	Kidney Carcinoma	GDSC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.7528
p.Y1338F	ACH-000457	Kidney Cancer	CCLE	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.7528
p.Y1338F	CAL-54	kidney	COSMIC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.7528
p.S1040R	SIDM00834	Colorectal Carcinoma	GDSC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7427
p.S1040R	ACH-000470	Colon/Colorectal Cancer	CCLE	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7427
p.S1040R	SW1463	large intestine	COSMIC	ASTST	DEG_SPOP_SBC_1	1037:1041	Mutation altering degron motif	0.7427
p.G894E	SIDM00284	Melanoma	GDSC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.G894E	ACH-000805	Skin Cancer	CCLE	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.G894E	COLO-679	skin	COSMIC	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.D555A	SIDM00457	Plasma Cell Myeloma	GDSC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1667
p.D555A	ACH-000024	Myeloma	CCLE	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1667
p.D555A	OPM-2	haematopoietic and lymphoid tissue	COSMIC	PSTSS	DEG_SPOP_SBC_1	545:549	Mutation rewiring degron network	0.1667
p.H487Y	SIDM01161	Other Sarcomas	GDSC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1944
p.H487Y	ACH-001274	Sarcoma	CCLE	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1944
p.H487Y	SW982	soft tissue	COSMIC	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation rewiring degron network	0.1944
p.Y1338N	SIDM00282	Colorectal Carcinoma	GDSC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.7059
p.Y1338N	ACH-000998	Colon/Colorectal Cancer	CCLE	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.7059
p.Y1338N	CW-2	large intestine	COSMIC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.7059
p.L1333F	SIDM01125	Non-Small Cell Lung Carcinoma	GDSC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.587
p.L1333F	ACH-000378	Lung Cancer	CCLE	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.587
p.L1333F	NCI-H647	lung	COSMIC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation altering degron motif	0.587
p.S686L	SIDM00837	Colorectal Carcinoma	GDSC	PISTS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7667
p.S686L	ACH-000958	Colon/Colorectal Cancer	CCLE	PISTS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7667
p.S686L	SW48	large intestine	COSMIC	PISTS	DEG_SPOP_SBC_1	682:686	Mutation altering degron motif	0.7667
p.S1329R	SIDM00032	Bladder Carcinoma	GDSC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.25
p.S1329R	ACH-000839	Bladder Cancer	CCLE	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.25
p.S1329R	SCaBER	urinary tract	COSMIC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.25
p.T1705S	SIDM00936	Bladder Carcinoma	GDSC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1944
p.T1705S	ACH-000142	Bladder Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1944
p.T1705S	CAL-29	urinary tract	COSMIC	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1944
p.Q382R	SIDM00179	Melanoma	GDSC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.6218
p.Q382R	ACH-002165	Skin Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.6218
p.Q382R	MZ2-MEL	skin	COSMIC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation altering degron motif	0.6218
p.P1351Q	SIDM01027	Esophageal Squamous Cell Carcinoma	GDSC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.0833
p.P1351Q	ACH-000865	Esophageal Cancer	CCLE	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.0833
p.P1351Q	KYSE-450	oesophagus	COSMIC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.0833
p.K371M	SIDM01681	Non-Cancerous	GDSC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation substituting flanking lysine	0.1667
p.K371M	ACH-002362	Non-Cancerous	CCLE	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation substituting flanking lysine	0.1667
p.S190P	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.2778
p.S190P	ACH-000416	Lung Cancer	CCLE	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.2778
p.S190P	NCI-H838	lung	COSMIC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.2778
p.V171I	SIDM01624	Bladder Carcinoma	GDSC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.0833
p.V171I	SIDM01529	Bladder Carcinoma	GDSC	PRVVLTPLK	DEG_APCC_DBOX_1	180:188	Mutation rewiring degron network	0.0833
p.L392H	SIDM01617	Endometrial Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.L392H	ACH-000994	Endometrial/Uterine Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1389
p.N1352D	SIDM01480	Ovarian Carcinoma	GDSC	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.0556
p.N1352D	ACH-000256	Ovarian Cancer	CCLE	NLVSTQYTSVP	CBL_PTK	1332:1342	Mutation rewiring degron network	0.0556
p.T373I	SIDM01767	Squamous Cell Lung Carcinoma	GDSC	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1111
p.T373I	ACH-000553	Lung Cancer	CCLE	AQSSS	DEG_SPOP_SBC_1	381:385	Mutation rewiring degron network	0.1111
p.M505T	ACH-001750	Sarcoma	CCLE	IAPPEDNLESCVMM	DEG_ODPH_VHL_1	492:505	Mutation altering degron motif	0.7423
p.L877I	ACH-001834	Bile Duct Cancer	CCLE	LSVFSE	LIG_APCC_ABBA_1	883:888	Mutation rewiring degron network	0.1667
p.Q1703R	ACH-002041	Thyroid Cancer	CCLE	ASTSS	DEG_SPOP_SBC_1	1710:1714	Mutation rewiring degron network	0.1389

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ASXL3

UniProt ID: Q9C0F0

Entrez ID: 80816

Protein name: Putative Polycomb group protein ASXL3 (Additional sex combs-like protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ASXL3 in