DegronMD

Uniprot ID: Q9C0F0

Source protein: Putative Polycomb group protein ASXL3

Source gene: ASXL3

Class: LIG_APCC_ABBA_1

Location: 883:888

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7625

ASA_SCORE: 82.4833

COIL: 0.8077

CONS_SCORE: 0.3124

DSS_SCORE: 0.4623

HELIX: 0.05

FCONS_SCORE: 0.884

RIG_SCORE: 0.7414

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.E888V	TCGA-A5-A0G1	UCEC	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.7693
p.E888V	DO42472	UCEC	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.7693
p.E896V	TCGA-AJ-A3IA	UCEC	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.1111
p.E896V	DO43082	UCEC	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.1111
p.E873K	TCGA-AP-A051	UCEC	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.0556
p.E873K	TCGA-L9-A8F4	LUAD	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.0556
p.E873K	DO49876	LUAD	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.0556
p.E873K	DO229229	THCA	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.0556
p.E873K	DO42673	UCEC	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.0556
p.D891N	TCGA-CR-5248	HNSC	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.25
p.D891N	DO14694	HNSC	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.25
p.E882K	TCGA-D3-A1Q8	SKCM	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.3056
p.E882K	TCGA-EB-A41A	SKCM	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.3056
p.E882K	DO37429	SKCM	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.3056
p.E882K	DO37446	SKCM	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.3056
p.P898S	TCGA-DU-6392	LGG	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.0556
p.P898S	DO22237	LGG	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.0556
p.L883F	TCGA-FS-A1ZF	SKCM	TCGA	LSVFSE	LIG_APCC_ABBA_1	0.587
p.L883F	DO38039	SKCM	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.587
p.P880R	DO233214	GACA	ICGC	LSVFSE	LIG_APCC_ABBA_1	0.25
p.G894E	SIDM00284	Melanoma	GDSC	LSVFSE	LIG_APCC_ABBA_1	0.1667
p.G894E	ACH-000805	Skin Cancer	CCLE	LSVFSE	LIG_APCC_ABBA_1	0.1667
p.G894E	COLO-679	skin	COSMIC	LSVFSE	LIG_APCC_ABBA_1	0.1667
p.L877I	ACH-001834	Bile Duct Cancer	CCLE	LSVFSE	LIG_APCC_ABBA_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0F0	Putative Polycomb group protein ASXL3	LIG_APCC_ABBA_1	883:888	LSVFSE	APC,CDC20,FZR1	0.7625	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons