DegronMD

Uniprot ID: Q9C0F0

Source protein: Putative Polycomb group protein ASXL3

Source gene: ASXL3

Class: DEG_APCC_DBOX_1

Location: 180:188

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.5578

ASA_SCORE: 95.3

COIL: 0.8477

CONS_SCORE: 0.3736

DSS_SCORE: 0.543

HELIX: 0.022

FCONS_SCORE: 1.1135

RIG_SCORE: 0.7825

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T185I	TCGA-2W-A8YY	CESC	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	0.7078
p.T185I	TCGA-B5-A3FA	UCEC	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	0.7078
p.T185I	DO223732	CESC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.7078
p.T185I	DO52402	UCEC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.7078
p.S196L	TCGA-AA-3864	COAD	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	0.1111
p.S196L	DO8490	COAD	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.1111
p.S196L	DO228963	LICA	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.1111
p.Q193K	TCGA-FA-A82F	DLBC	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	0.1944
p.Q193K	DO219891	DLBC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.1944
p.M173I	TCGA-OL-A5RZ	BRCA	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	0.1389
p.M173I	TCGA-OR-A5LJ	ACC	TCGA	PRVVLTPLK	DEG_APCC_DBOX_1	0.1389
p.M173I	DO44228	BRCA	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.1389
p.V182F	DO229028	LICA	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.5957
p.M174T	DO231732	LINC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.1667
p.G170V	DO231047	LUSC	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.0556
p.R181C	DO229462	SKCA	ICGC	PRVVLTPLK	DEG_APCC_DBOX_1	0.8301
p.Q193L	SIDM00113	Kidney Carcinoma	GDSC	PRVVLTPLK	DEG_APCC_DBOX_1	0.1944
p.Q193L	TK10	kidney	COSMIC	PRVVLTPLK	DEG_APCC_DBOX_1	0.1944
p.S190P	SIDM01150	Non-Small Cell Lung Carcinoma	GDSC	PRVVLTPLK	DEG_APCC_DBOX_1	0.2778
p.S190P	ACH-000416	Lung Cancer	CCLE	PRVVLTPLK	DEG_APCC_DBOX_1	0.2778
p.S190P	NCI-H838	lung	COSMIC	PRVVLTPLK	DEG_APCC_DBOX_1	0.2778
p.V171I	SIDM01624	Bladder Carcinoma	GDSC	PRVVLTPLK	DEG_APCC_DBOX_1	0.0833
p.V171I	SIDM01529	Bladder Carcinoma	GDSC	PRVVLTPLK	DEG_APCC_DBOX_1	0.0833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_APCC_DBOX_1	180:188	PRVVLTPLK	APC,CDC20,FZR1	0.5578	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons