DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
NLVSTQYTSVP
Uniprot ID:
Q9C0F0
Source protein:
Putative Polycomb group protein ASXL3
Source gene:
ASXL3
Class:
CBL_PTK
Location:
1332:1342
E3 ligase:
CBL
DEGRON score:
0.7272
ASA_SCORE:
95.3727
COIL:
0.9017
CONS_SCORE:
0.2842
DSS_SCORE:
0.3961
HELIX:
0.0467
FCONS_SCORE:
0.8698
RIG_SCORE:
0.7043
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1331R
TCGA-55-7283
LUAD
TCGA
NLVSTQYTSVP
CBL_PTK
0.3056
p.S1331R
DO23606
LUAD
ICGC
NLVSTQYTSVP
CBL_PTK
0.3056
p.L1324Q
TCGA-AG-3890
READ
TCGA
NLVSTQYTSVP
CBL_PTK
0.1111
p.L1324Q
DO36431
READ
ICGC
NLVSTQYTSVP
CBL_PTK
0.1111
p.L1350S
TCGA-AJ-A3EL
UCEC
TCGA
NLVSTQYTSVP
CBL_PTK
0.1111
p.L1350S
DO41542
UCEC
ICGC
NLVSTQYTSVP
CBL_PTK
0.1111
p.A1330D
TCGA-AP-A059
UCEC
TCGA
NLVSTQYTSVP
CBL_PTK
0.2778
p.A1330D
DO41361
UCEC
ICGC
NLVSTQYTSVP
CBL_PTK
0.2778
p.N1332D
DO233867
GACA
ICGC
NLVSTQYTSVP
CBL_PTK
0.5821
p.T1336P
SIDM01302
Esophageal Carcinoma
GDSC
NLVSTQYTSVP
CBL_PTK
0.5919
p.Y1338F
SIDM00932
Kidney Carcinoma
GDSC
NLVSTQYTSVP
CBL_PTK
0.7528
p.Y1338F
ACH-000457
Kidney Cancer
CCLE
NLVSTQYTSVP
CBL_PTK
0.7528
p.Y1338F
CAL-54
kidney
COSMIC
NLVSTQYTSVP
CBL_PTK
0.7528
p.Y1338N
SIDM00282
Colorectal Carcinoma
GDSC
NLVSTQYTSVP
CBL_PTK
0.7059
p.Y1338N
ACH-000998
Colon/Colorectal Cancer
CCLE
NLVSTQYTSVP
CBL_PTK
0.7059
p.Y1338N
CW-2
large_intestine
COSMIC
NLVSTQYTSVP
CBL_PTK
0.7059
p.L1333F
SIDM01125
Non-Small Cell Lung Carcinoma
GDSC
NLVSTQYTSVP
CBL_PTK
0.587
p.L1333F
ACH-000378
Lung Cancer
CCLE
NLVSTQYTSVP
CBL_PTK
0.587
p.L1333F
NCI-H647
lung
COSMIC
NLVSTQYTSVP
CBL_PTK
0.587
p.S1329R
SIDM00032
Bladder Carcinoma
GDSC
NLVSTQYTSVP
CBL_PTK
0.25
p.S1329R
ACH-000839
Bladder Cancer
CCLE
NLVSTQYTSVP
CBL_PTK
0.25
p.S1329R
SCaBER
urinary_tract
COSMIC
NLVSTQYTSVP
CBL_PTK
0.25
p.P1351Q
SIDM01027
Esophageal Squamous Cell Carcinoma
GDSC
NLVSTQYTSVP
CBL_PTK
0.0833
p.P1351Q
ACH-000865
Esophageal Cancer
CCLE
NLVSTQYTSVP
CBL_PTK
0.0833
p.P1351Q
KYSE-450
oesophagus
COSMIC
NLVSTQYTSVP
CBL_PTK
0.0833
p.N1352D
SIDM01480
Ovarian Carcinoma
GDSC
NLVSTQYTSVP
CBL_PTK
0.0556
p.N1352D
ACH-000256
Ovarian Cancer
CCLE
NLVSTQYTSVP
CBL_PTK
0.0556
Drug responses associated with ASXL3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of NLVSTQYTSVP
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q9C0F0
Putative Polycomb group protein ASXL3
CBL_PTK
1332:1342
NLVSTQYTSVP
CBL
0.7272
More...
