DegronMD

Uniprot ID: Q9C0F0

Source protein: Putative Polycomb group protein ASXL3

Source gene: ASXL3

Class: DEG_SPOP_SBC_1

Location: 1217:1221

E3 ligase: SPOP

DEGRON score: 0.755

ASA_SCORE: 84.36

COIL: 0.8976

CONS_SCORE: 0.4032

DSS_SCORE: 0.4342

HELIX: 0.0292

FCONS_SCORE: 1.0604

RIG_SCORE: 0.6735

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S1221C	TCGA-C5-A1BM	CESC	TCGA	VSSTS	DEG_SPOP_SBC_1	0.7541
p.S1221C	DO49007	CESC	ICGC	VSSTS	DEG_SPOP_SBC_1	0.7541
p.T1220P	DO222941	BTCA	ICGC	VSSTS	DEG_SPOP_SBC_1	0.7031
p.S1218L	TCGA-EE-A2GL	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	0.6556
p.S1218L	DO229456	SKCA	ICGC	VSSTS	DEG_SPOP_SBC_1	0.6556
p.S1218L	DO37434	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	0.6556
p.S1221T	SIDM00506	Small Cell Lung Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	0.6005
p.S1221T	ACH-000508	Lung Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	0.6005
p.S1221T	COR-L88	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	0.6005
p.I1216M	TCGA-CA-6718	COAD	TCGA	VSSTS	DEG_SPOP_SBC_1	0.3056
p.I1216M	DO7801	COAD	ICGC	VSSTS	DEG_SPOP_SBC_1	0.3056
p.K1215Q	DO50824	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	0.2778
p.E1223A	DO228824	MALY	ICGC	VSSTS	DEG_SPOP_SBC_1	0.2778
p.E1223K	DO222363	MELA	ICGC	VSSTS	DEG_SPOP_SBC_1	0.2778
p.E1223D	DO227688	SKCA	ICGC	VSSTS	DEG_SPOP_SBC_1	0.2778
p.E1214D	TCGA-AP-A1E0	UCEC	TCGA	VSSTS	DEG_SPOP_SBC_1	0.25
p.E1214D	DO43154	UCEC	ICGC	VSSTS	DEG_SPOP_SBC_1	0.25
p.S1213F	TCGA-3N-A9WC	SKCM	TCGA	VSSTS	DEG_SPOP_SBC_1	0.2222
p.S1213F	DO51234	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	0.2222
p.S1213T	SIDM00845	Burkitt's Lymphoma	GDSC	VSSTS	DEG_SPOP_SBC_1	0.2222
p.P1228S	TCGA-BR-4201	STAD	TCGA	VSSTS	DEG_SPOP_SBC_1	0.1389
p.P1228S	DO38707	STAD	ICGC	VSSTS	DEG_SPOP_SBC_1	0.1389
p.M1229K	TCGA-55-8506	LUAD	TCGA	VSSTS	DEG_SPOP_SBC_1	0.1111
p.M1229K	DO45390	LUAD	ICGC	VSSTS	DEG_SPOP_SBC_1	0.1111
p.V1209E	TCGA-DD-AADA	LIHC	TCGA	VSSTS	DEG_SPOP_SBC_1	0.1111

Showing 1 to 25 of 26 entries

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Drug responses associated with ASXL3 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VSSTS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	664:668	VSSTS	SPOP	0.9924	More...
Q9H4G0	Band 4.1-like protein 1	DEG_SPOP_SBC_1	610:614	VSSTS	SPOP	0.92	More...
Q9HCM4	Band 4.1-like protein 5	DEG_SPOP_SBC_1	655:659	VSSTS	SPOP	0.9712	More...
P32246	C-C chemokine receptor type 1	DEG_SPOP_SBC_1	339:343	VSSTS	SPOP	0.8417	More...
Q4AC94	C2 domain-containing protein 3	DEG_SPOP_SBC_1	150:154	VSSTS	SPOP	0.7703	More...
P98194	Calcium-transporting ATPase type 2C member 1	DEG_SPOP_SBC_1	909:913	VSSTS	SPOP	0.7013	More...
Q14444	Caprin-1	DEG_SPOP_SBC_1	435:439	VSSTS	SPOP	0.9876	More...
Q96P56	Cation channel sperm-associated protein 2	DEG_SPOP_SBC_1	446:450	VSSTS	SPOP	0.9902	More...
P15336	Cyclic AMP-dependent transcription factor ATF-2	DEG_SPOP_SBC_1	463:467	VSSTS	SPOP	0.9197	More...
Q9UER7	Death domain-associated protein 6	DEG_SPOP_SBC_1	608:612	VSSTS	SPOP	0.9192	More...
Q7Z7J5	Developmental pluripotency-associated protein 2	DEG_SPOP_SBC_1	44:48	VSSTS	SPOP	0.9982	More...
P49792	E3 SUMO-protein ligase RanBP2	DEG_SPOP_SBC_1	2497:2501	VSSTS	SPOP	0.9395	More...
Q5JQS6	Germinal center-associated signaling and motility-like protein	DEG_SPOP_SBC_1	50:54	VSSTS	SPOP	0.9925	More...
Q2T9L4	Inhibitory synaptic factor 1	DEG_SPOP_SBC_1	78:82	VSSTS	SPOP	0.9827	More...
Q6TDP4	Kelch-like protein 17	DEG_SPOP_SBC_1	637:641	VSSTS	SPOP	0.7137	More...
Q9NZQ3	NCK-interacting protein with SH3 domain	DEG_SPOP_SBC_1	218:222	VSSTS	SPOP	0.9877	More...
Q8IVL1	Neuron navigator 2	DEG_SPOP_SBC_1	1675:1679	VSSTS	SPOP	0.8575	More...
Q8IVL0	Neuron navigator 3	DEG_SPOP_SBC_1	1552:1556	VSSTS	SPOP	0.936	More...
P35658	Nuclear pore complex protein Nup214	DEG_SPOP_SBC_1	984:988	VSSTS	SPOP	0.9993	More...
Q9Y6Q9	Nuclear receptor coactivator 3	DEG_SPOP_SBC_1	667:671	VSSTS	SPOP	0.9399	More...
O15544	Protein GR6	DEG_SPOP_SBC_1	16:20	VSSTS	SPOP	0.9463	More...
Q92833	Protein Jumonji	DEG_SPOP_SBC_1	88:92	VSSTS	SPOP	0.985	More...
Q8N9Q2	Protein SREK1IP1	DEG_SPOP_SBC_1	44:48	VSSTS	SPOP	0.9807	More...
C9J202	Putative glycosyltransferase ALG1L2	DEG_SPOP_SBC_1	78:82	VSSTS	SPOP	0.7087	More...
Q9C0F0	Putative Polycomb group protein ASXL3	DEG_SPOP_SBC_1	1217:1221	VSSTS	SPOP	0.755	More...

Showing 1 to 25 of 38 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VSSTS

Degron related mutations and impact score

Drug responses associated with ASXL3 mutations

All proteins holding degron of VSSTS