DegronMD - Q8TCU4(ALMS1)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S572T	TCGA-12-0829	GBM	TCGA	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6005
p.S572T	TCGA-23-1032	OV	TCGA	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6005
p.S572T	DO11166	GBM	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6005
p.S572T	DO32267	OV	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6005
p.S573P	TCGA-12-0829	GBM	TCGA	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6752
p.S573P	TCGA-23-1032	OV	TCGA	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6752
p.S573P	DO11166	GBM	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6752
p.S573P	DO32267	OV	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6752
p.K1149N	TCGA-17-Z030	LUAD	TCGA	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.1667
p.T1281S	TCGA-21-1075	LUSC	TCGA	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation altering degron motif	0.7116
p.T1281S	DO26484	LUSC	ICGC	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation altering degron motif	0.7116
p.D844N	TCGA-23-1114	OV	TCGA	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1111
p.R1667K	TCGA-29-1694	OV	TCGA	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation rewiring degron network	0.25
p.G3983C	TCGA-33-AASB	LUSC	TCGA	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.1667
p.G3983V	TCGA-33-AASB	LUSC	TCGA	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.1667
p.T3901I	TCGA-34-2600	LUSC	TCGA	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.0833
p.T3901I	DO27081	LUSC	ICGC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.0833
p.H668Y	TCGA-34-8454	LUSC	TCGA	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.7229
p.H668Y	DO50094	LUSC	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.7229
p.E1040V	TCGA-43-5668	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.1944
p.E1040V	DO26608	LUSC	ICGC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.1944
p.R1052M	TCGA-43-A56U	LUSC	TCGA	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.25
p.R1052M	DO49083	LUSC	ICGC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.25
p.L862V	TCGA-50-5066	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.L862V	DO25040	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1667
p.V1280L	TCGA-55-8506	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation altering degron motif	0.6765
p.V1280L	DO45390	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation altering degron motif	0.6765
p.G1668W	TCGA-66-2782	LUSC	TCGA	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation rewiring degron network	0.2222
p.G1668W	DO26680	LUSC	ICGC	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation rewiring degron network	0.2222
p.P850R	TCGA-95-7947	LUAD	TCGA	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2778
p.P850R	DO26404	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2778
p.R4085W	TCGA-A5-A0G2	UCEC	TCGA	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.2778
p.R3630H	TCGA-AA-3967	COAD	TCGA	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.25
p.V1044A	TCGA-AJ-A3EL	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.3056
p.V1044A	DO41542	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.3056
p.E1053D	TCGA-AN-A046	BRCA	TCGA	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.E1053D	DO1285	BRCA	ICGC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.S762A	TCGA-AP-A056	UCEC	TCGA	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.7588
p.S762A	DO43971	UCEC	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.7588
p.T1137I	TCGA-AP-A059	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.2778
p.G3981D	TCGA-AX-A1C9	UCEC	TCGA	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.2222
p.G3981D	DO43098	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.2222
p.T566I	TCGA-B5-A11H	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2222
p.T566I	DO42825	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2222
p.S3914I	TCGA-B5-A1MY	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation altering degron motif	0.623
p.R3902Q	TCGA-B5-A3FA	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.1111
p.E1053K	TCGA-B7-A5TI	STAD	TCGA	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.E1053K	DO222328	STAD	ICGC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.2222
p.G1134S	TCGA-BR-4368	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.1944
p.G1134S	DO38715	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.1944
p.H1905N	TCGA-BR-A4CS	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.0556
p.H1905N	DO47965	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.0556
p.E3920A	TCGA-BS-A0UA	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.1944
p.T1464M	TCGA-BS-A0UL	UCEC	TCGA	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.2778
p.A1457S	TCGA-CC-A5UD	LIHC	TCGA	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.0833
p.A1457S	DO219552	LIHC	ICGC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.0833
p.R4075W	TCGA-CG-4460	STAD	TCGA	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.8634
p.R4075W	DO38427	STAD	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.8634
p.V1057A	TCGA-CG-5723	STAD	TCGA	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.1111
p.D505A	TCGA-CN-A63T	HNSC	TCGA	ITTTPVDS	DEG_SCF_FBW7_1	497:504	Mutation rewiring degron network	0.3056
p.D505A	DO49040	HNSC	ICGC	ITTTPVDS	DEG_SCF_FBW7_1	497:504	Mutation rewiring degron network	0.3056
p.R3627G	TCGA-CR-7388	HNSC	TCGA	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation altering degron motif	0.7568
p.R4091C	TCGA-D3-A51G	SKCM	TCGA	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.1111
p.R4091C	DO47700	SKCM	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.1111
p.P3911L	TCGA-D3-A8GN	SKCM	TCGA	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation altering degron motif	0.7582
p.P3911L	DO51240	SKCM	ICGC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation altering degron motif	0.7582
p.G1371D	TCGA-D7-A4YY	STAD	TCGA	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.G1371D	DO47733	STAD	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.R3256H	TCGA-D7-A4Z0	STAD	TCGA	ASSSS	DEG_SPOP_SBC_1	3245:3249	Mutation blocking phosphorylation signal	0.5833
p.R3256H	DO47765	STAD	ICGC	ASSSS	DEG_SPOP_SBC_1	3245:3249	Mutation blocking phosphorylation signal	0.5833
p.S861P	TCGA-DF-A2KU	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1944
p.S861P	DO223286	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1944
p.S1814F	TCGA-DK-A6B6	BLCA	TCGA	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation rewiring degron network	0.0833
p.S1814F	TCGA-YD-A89C	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation rewiring degron network	0.0833
p.S1814F	DO48576	BLCA	ICGC	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation rewiring degron network	0.0833
p.S1814F	DO219501	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation rewiring degron network	0.0833
p.T753N	TCGA-DU-6392	LGG	TCGA	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation substituting flanking lysine	0.2778
p.T753N	DO22237	LGG	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation substituting flanking lysine	0.2778
p.T1141I	TCGA-DU-6392	LGG	TCGA	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7078
p.T1141I	DO22237	LGG	ICGC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7078
p.T1141I	ACH-000548	Head and Neck Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7078
p.Q1273H	TCGA-E2-A108	BRCA	TCGA	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.1389
p.G1466D	TCGA-E6-A1LX	UCEC	TCGA	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation altering degron motif	0.7198
p.G1466D	DO41020	UCEC	ICGC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation altering degron motif	0.7198
p.G1466D	ACH-000299	Leukemia	CCLE	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation altering degron motif	0.7198
p.D4082Y	TCGA-E7-A541	BLCA	TCGA	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.7325
p.S860C	TCGA-E7-A5KF	BLCA	TCGA	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2222
p.S860C	DO44038	BLCA	ICGC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2222
p.G845E	TCGA-E9-A1NC	BRCA	TCGA	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.1389
p.R3630C	TCGA-EB-A550	SKCM	TCGA	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.25
p.R3630C	ACH-000750	Skin Cancer	CCLE	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.25
p.R3630C	ACH-000971	Colon/Colorectal Cancer	CCLE	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.25
p.R4083K	TCGA-EB-A97M	SKCM	TCGA	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.7237
p.Q1652K	TCGA-EE-A2GK	SKCM	TCGA	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation rewiring degron network	0.1111
p.R4075L	TCGA-EE-A2GL	SKCM	TCGA	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.8428
p.R4075L	DO37434	SKCM	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.8428
p.S1388N	TCGA-EE-A2MC	SKCM	TCGA	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.S1388N	DO232761	PBCA	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.S1388N	DO37559	SKCM	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.S1388N	ACH-001203	Lymphoma	CCLE	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.P1042Q	TCGA-EE-A2MM	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.25
p.P1278Q	TCGA-EE-A2MM	SKCM	TCGA	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.2778
p.P1278Q	DO37770	SKCM	ICGC	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.2778
p.P769S	TCGA-EE-A3AF	SKCM	TCGA	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation blocking ubiquitination signal	0.6111
p.P769S	DO50946	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation blocking ubiquitination signal	0.6111
p.P769S	DO37911	SKCM	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation blocking ubiquitination signal	0.6111
p.T1656P	TCGA-EO-A22R	UCEC	TCGA	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation rewiring degron network	0.2222
p.T1656P	DO42713	UCEC	ICGC	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation rewiring degron network	0.2222
p.R3066I	TCGA-EO-A3B0	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	3053:3057	Mutation rewiring degron network	0.0833
p.S3922R	TCGA-EY-A215	UCEC	TCGA	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.1389
p.A858V	TCGA-FI-A2D0	UCEC	TCGA	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2778
p.A858V	DO43891	UCEC	ICGC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2778
p.A858V	ACH-000999	Colon/Colorectal Cancer	CCLE	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.2778
p.F3067L	TCGA-FI-A2D5	UCEC	TCGA	PKTSS	DEG_SPOP_SBC_1	3053:3057	Mutation rewiring degron network	0.0556
p.G578R	TCGA-FI-A2F4	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2222
p.G578R	DO43434	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2222
p.S495L	TCGA-FU-A3HY	CESC	TCGA	ITTTPVDS	DEG_SCF_FBW7_1	497:504	Mutation rewiring degron network	0.2778
p.P998L	TCGA-FW-A3R5	SKCM	TCGA	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.2778
p.P998L	DO37406	SKCM	ICGC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.2778
p.S764L	TCGA-G2-A3VY	BLCA	TCGA	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation blocking phosphorylation signal	0.75
p.S764L	DO590	BLCA	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation blocking phosphorylation signal	0.75
p.K3242E	TCGA-G4-6628	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	3245:3249	Mutation rewiring degron network	0.25
p.S762F	TCGA-IR-A3LH	CESC	TCGA	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.7982
p.S762F	DO44381	CESC	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.7982
p.P1387L	TCGA-KK-A59V	PRAD	TCGA	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation substituting flanking lysine	0.25
p.P1387L	DO51346	PRAD	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation substituting flanking lysine	0.25
p.P1387L	ACH-000674	Gastric Cancer	CCLE	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation substituting flanking lysine	0.25
p.I1889L	TCGA-NH-A8F7	COAD	TCGA	ASSSS	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.2778
p.I1889L	DO51729	COAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.2778
p.E3974K	TCGA-Q1-A73O	CESC	TCGA	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation altering degron motif	0.7022
p.E3974K	DO51612	CESC	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation altering degron motif	0.7022
p.P1150S	TCGA-QF-A5YS	UCEC	TCGA	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation substituting flanking lysine	0.25
p.P1150S	DO52426	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation substituting flanking lysine	0.25
p.P3052S	TCGA-UY-A9PD	BLCA	TCGA	NRKALSCVH	DEG_APCC_DBOX_1	3040:3048	Mutation rewiring degron network	0.2222
p.P3052S	TCGA-UY-A9PD	BLCA	TCGA	PKTSS	DEG_SPOP_SBC_1	3053:3057	Mutation rewiring degron network	0.3056
p.E4084K	TCGA-YD-A89C	SKCM	TCGA	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.3056
p.P1473L	TCGA-YD-A9TA	SKCM	TCGA	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.3056
p.P1473L	DO219503	SKCM	ICGC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.3056
p.V569I	TCGA-ZB-A96A	THYM	TCGA	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.3056
p.Y678C	DO48370	BLCA	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.0556
p.F4079L	DO48448	BLCA	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.6981
p.S3049W	DO219049	BLCA	ICGC	NRKALSCVH	DEG_APCC_DBOX_1	3040:3048	Mutation rewiring degron network	0.3056
p.S3049W	DO219049	BLCA	ICGC	PKTSS	DEG_SPOP_SBC_1	3053:3057	Mutation rewiring degron network	0.2222
p.S1475R	DO225322	BRCA	ICGC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.25
p.D3610N	DO2943	BRCA	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.0833
p.S761T	DO222643	BTCA	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.6005
p.S761T	ACH-000582	Skin Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.6005
p.D1130N	DO222768	BTCA	ICGC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.0833
p.H576Q	DO6392	CLLE	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation blocking phosphorylation signal	0.7222
p.G3970S	DO8224	COAD	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.25
p.L1657S	DO222884	COCA	ICGC	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation rewiring degron network	0.25
p.V671G	DO229010	COCA	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.V671G	DO229013	COCA	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.V671G	DO229016	COCA	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.V671G	DO229003	COCA	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.V671G	DO229005	COCA	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.V671G	DO229505	LAML	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.V671G	DO225404	LAML	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.V671G	DO229053	LICA	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.R3987K	DO229010	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.R3987K	DO229013	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.R3987K	DO229016	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.R3987K	DO229003	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.R3987K	DO229005	COCA	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.R3987K	DO234285	ESAD	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.R3987K	DO229505	LAML	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.G1884D	DO50326	ESAD	ICGC	ASSSS	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1389
p.T566K	DO234160	ESAD	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2222
p.I999L	DO222601	ESCA	ICGC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.25
p.A1279T	DO228805	GACA	ICGC	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.3056
p.V3976M	DO233088	GACA	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation altering degron motif	0.7208
p.T489A	DO233764	GACA	ICGC	ITTTPVDS	DEG_SCF_FBW7_1	497:504	Mutation rewiring degron network	0.1111
p.T658M	DO233884	GACA	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation substituting flanking lysine	0.2778
p.K757E	DO15294	HNSC	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation rewiring degron network	0.2778
p.S4076F	DO52087	HNSC	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.7982
p.R1374Q	DO227513	LAML	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.2778
p.Q1131K	DO231954	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.1111
p.R3903I	DO228944	LICA	ICGC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.1389
p.V3252F	DO228948	LICA	ICGC	ASSSS	DEG_SPOP_SBC_1	3245:3249	Mutation rewiring degron network	0.25
p.G1370V	DO228952	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1667
p.G1134V	DO228971	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.1944
p.S1047I	DO228986	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7341
p.Q4082H	DO229019	LICA	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.7582
p.R3627I	DO229022	LICA	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation altering degron motif	0.8102
p.D3067Y	DO229025	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	3053:3057	Mutation rewiring degron network	0.0556
p.S3621I	DO229031	LICA	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation altering degron motif	0.7341
p.R3970I	DO229031	LICA	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.25
p.A3065V	DO229050	LICA	ICGC	PKTSS	DEG_SPOP_SBC_1	3053:3057	Mutation rewiring degron network	0.1111
p.T1374A	DO229055	LICA	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.2778
p.D3610Y	DO229008	LICA	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.0833
p.L760Q	DO44828	LICA	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.7765
p.V3617M	DO48587	LIHC	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.2778
p.K4069R	DO23228	LINC	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.1667
p.I109S	DO23288	LINC	ICGC	ERTSLEKIV	DEG_APCC_DBOX_1	102:110	Mutation altering degron motif	0.7341
p.R3635Q	DO23356	LINC	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.1111
p.Q853E	DO26404	LUAD	ICGC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation altering degron motif	0.6744
p.E772D	DO24740	LUAD	ICGC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation rewiring degron network	0.0833
p.P4066L	DO24702	LUAD	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.0833
p.I4067M	DO24702	LUAD	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation blocking ubiquitination signal	0.5556
p.Q3250H	DO231207	LUSC	ICGC	ASSSS	DEG_SPOP_SBC_1	3245:3249	Mutation rewiring degron network	0.3056
p.Q1796E	DO219133	LUSC	ICGC	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation rewiring degron network	0.1944
p.Y1288H	DO228281	MALY	ICGC	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation rewiring degron network	0.2222
p.P111S	DO222843	MELA	ICGC	ERTSLEKIV	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.3056
p.T671S	DO28154	OV	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.A3975T	DO46657	PAAD	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation altering degron motif	0.7139
p.A1881P	DO46730	PACA	ICGC	ASSSS	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.0556
p.R1143K	DO36556	READ	ICGC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7237
p.Q661K	DO37896	SKCM	ICGC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.S1479F	DO37819	SKCM	ICGC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.1389
p.P1000Q	DO37770	SKCM	ICGC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.2222
p.P1478L	DO38099	SKCM	ICGC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.1667
p.S578F	DO219501	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.2222
p.L984P	DO51795	STAD	ICGC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.2222
p.S3912A	DO229268	THCA	ICGC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation altering degron motif	0.7588
p.V3916A	DO50078	UCEC	ICGC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.3056
p.R3635W	DO43306	UCEC	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.1111
p.E119K	DO41020	UCEC	ICGC	ERTSLEKIV	DEG_APCC_DBOX_1	102:110	Mutation rewiring degron network	0.0833
p.A3030V	DO42280	UCEC	ICGC	NRKALSCVH	DEG_APCC_DBOX_1	3040:3048	Mutation rewiring degron network	0.0556
p.H1388R	DO41644	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.R3635L	DO41847	UCEC	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.1111
p.R3971W	DO41235	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.2778
p.R3971W	DO41331	UCEC	ICGC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.2778
p.E1390G	DO41199	UCEC	ICGC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.0556
p.K4077T	DO42745	UCEC	ICGC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.7306
p.S1389N	SIDM00422	Hodgkin's Lymphoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.0833
p.S1389N	SUP-HD1	haematopoietic and lymphoid tissue	COSMIC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.0833
p.P1388L	SIDM00570	Gastric Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.P1388L	NUGC-4	stomach	COSMIC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.V1045I	SIDM00373	Endometrial Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7076
p.V1045I	SNG-M	endometrium	COSMIC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7076
p.T1385R	SIDM01015	Chronic Myelogenous Leukemia	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.T1385R	SIDM00845	Burkitt's Lymphoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.T1385R	SIDM00200	Ewing's Sarcoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.T1385R	SIDM00878	Breast Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.T1385R	SIDM00114	Non-Small Cell Lung Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.T1385R	SIDM00849	Kidney Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.T1385R	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1944
p.I3635L	SIDM00962	Chronic Myelogenous Leukemia	GDSC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.1111
p.I3635L	BV-173	haematopoietic and lymphoid tissue	COSMIC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.1111
p.S762T	SIDM01483	Melanoma	GDSC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.6005
p.S762T	COLO-741	large intestine	COSMIC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation altering degron motif	0.6005
p.L1059W	SIDM00919	Ovarian Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.0556
p.L1059W	Caov-3	ovary	COSMIC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.0556
p.S3986F	SIDM00007	Other Solid Cancers	GDSC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0833
p.S3986F	MCC13	skin	COSMIC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0833
p.V664L	SIDM00660	Colorectal Carcinoma	GDSC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.6765
p.V664L	LS-411N	large intestine	COSMIC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation altering degron motif	0.6765
p.K1811N	SIDM00529	Breast Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation blocking ubiquitination signal	0.6111
p.K1811N	SIDM00309	Mesothelioma	GDSC	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation blocking ubiquitination signal	0.6111
p.K1811N	SIDM00793	Burkitt's Lymphoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation blocking ubiquitination signal	0.6111
p.S573G	SIDM01172	Acute Myeloid Leukemia	GDSC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6993
p.T1663I	SIDM00703	Non-Small Cell Lung Carcinoma	GDSC	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation altering degron motif	0.8189
p.T1663I	SIDM00493	Other Solid Cancers	GDSC	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation altering degron motif	0.8189
p.V3963A	SIDM00683	Prostate Carcinoma	GDSC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.V3963A	LNCaP-Clone-FGC	prostate	COSMIC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.0556
p.P3037R	SIDM00505	Pancreatic Carcinoma	GDSC	NRKALSCVH	DEG_APCC_DBOX_1	3040:3048	Mutation rewiring degron network	0.25
p.P3037R	MIA-PaCa-2	pancreas	COSMIC	NRKALSCVH	DEG_APCC_DBOX_1	3040:3048	Mutation rewiring degron network	0.25
p.R3631C	SIDM00149	Melanoma	GDSC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.2222
p.R3631C	SIDM00783	Colorectal Carcinoma	GDSC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.2222
p.R3631C	HCT-116	large intestine	COSMIC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.2222
p.R3631C	LOXIMVI	skin	COSMIC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.2222
p.S511F	SIDM00140	Melanoma	GDSC	ITTTPVDS	DEG_SCF_FBW7_1	497:504	Mutation blocking phosphorylation signal	0.5833
p.S511F	ACH-000968	Skin Cancer	CCLE	ITTTPVDS	DEG_SCF_FBW7_1	497:504	Mutation blocking phosphorylation signal	0.5833
p.T1470N	SIDM00561	Other Blood Cancers	GDSC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation altering degron motif	0.5944
p.T1470N	MLMA	haematopoietic and lymphoid tissue	COSMIC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation altering degron motif	0.5944
p.A859V	SIDM00217	Colorectal Carcinoma	GDSC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.25
p.A859V	SNU-1040	large intestine	COSMIC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation rewiring degron network	0.25
p.R4092H	SIDM00217	Colorectal Carcinoma	GDSC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.0833
p.R4092H	SNU-1040	large intestine	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.0833
p.T1142I	SIDM00986	Head and Neck Carcinoma	GDSC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7078
p.T1142I	BHY	upper aerodigestive tract	COSMIC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation altering degron motif	0.7078
p.N3922D	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.1389
p.N3922D	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.1389
p.P1035Q	SIDM00257	Neuroblastoma	GDSC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.0556
p.P1035Q	NB13	autonomic ganglia	COSMIC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.0556
p.S1000L	SIDM00381	Cervical Carcinoma	GDSC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.2222
p.S1000L	SKG-IIIa	cervix	COSMIC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.2222
p.S3057P	SIDM01336	Glioblastoma	GDSC	PKTSS	DEG_SPOP_SBC_1	3053:3057	Mutation altering degron motif	0.6752
p.P1035S	SIDM01758	B-Cell Non-Hodgkin's Lymphoma	GDSC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.0556
p.H575Y	SIDM01446	Glioblastoma	GDSC	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.3056
p.S1049A	SIDM01450	Gastric Carcinoma	GDSC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7588
p.S572G	ACH-000146	Leukemia	CCLE	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.6993
p.E4074K	ACH-000328	Brain Cancer	CCLE	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.3056
p.S3056P	ACH-000368	Brain Cancer	CCLE	PKTSS	DEG_SPOP_SBC_1	3053:3057	Mutation altering degron motif	0.6752
p.I3634L	ACH-000432	Leukemia	CCLE	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation substituting flanking lysine	0.25
p.H574Y	ACH-000543	Brain Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation altering degron motif	0.7229
p.P3036R	ACH-000601	Pancreatic Cancer	CCLE	NRKALSCVH	DEG_APCC_DBOX_1	3040:3048	Mutation blocking phosphorylation signal	0.6667
p.S1284A	ACH-000687	Lymphoma	CCLE	AVTST	DEG_SPOP_SBC_1	1280:1284	Mutation altering degron motif	0.7588
p.L1058W	ACH-000713	Ovarian Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.0833
p.H3047R	ACH-000786	Lymphoma	CCLE	NRKALSCVH	DEG_APCC_DBOX_1	3040:3048	Mutation altering degron motif	0.8244
p.S1048A	ACH-000898	Gastric Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation altering degron motif	0.7588
p.A4077V	ACH-000937	Leukemia	CCLE	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.6936
p.V1044I	ACH-000974	Endometrial/Uterine Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.3056
p.V1044I	ACH-002026	Endometrial/Uterine Cancer	CCLE	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.3056
p.V663L	ACH-000985	Colon/Colorectal Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.3056
p.T1654I	ACH-001367	Neuroblastoma	CCLE	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation substituting flanking lysine	0.2778
p.Q3611L	ACH-001396	Metastasis	CCLE	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.1111
p.H509Y	ACH-001413	Bladder Cancer	CCLE	ITTTPVDS	DEG_SCF_FBW7_1	497:504	Mutation rewiring degron network	0.1944
p.S3985F	ACH-001550	Skin Cancer	CCLE	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.1111
p.R577K	ACH-001610	Brain Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	570:574	Mutation rewiring degron network	0.25
p.H670R	ACH-001610	Brain Cancer	CCLE	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.2778
p.S999L	ACH-002020	Cervical Cancer	CCLE	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.25
p.T1469N	ACH-002274	Leukemia	CCLE	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation altering degron motif	0.7055
p.T3925P	ACH-002278	Neuroblastoma	CCLE	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.0556
p.Q4075R	SR	haematopoietic and lymphoid tissue	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.7329
p.Q4075R	BT-474	breast	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.7329
p.Q4075R	HT-115	large intestine	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation altering degron motif	0.7329
p.S1664L	A253	salivary gland	COSMIC	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation altering degron motif	0.7667
p.S1664L	SKG-IIIa	cervix	COSMIC	VHSTS	DEG_SPOP_SBC_1	1660:1664	Mutation altering degron motif	0.7667
p.V3921A	LNCaP-Clone-FGC	prostate	COSMIC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation rewiring degron network	0.1667
p.T503I	NCI-H727	lung	COSMIC	ITTTPVDS	DEG_SCF_FBW7_1	497:504	Mutation altering degron motif	0.7078
p.P673S	COLO-792	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.1944
p.P1383L	SW684	soft tissue	COSMIC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.25
p.D661Y	NCI-H1355	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.L670V	JHU-011	upper aerodigestive tract	COSMIC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.2778
p.R1902T	NCI-H460	lung	COSMIC	ASSSS	DEG_SPOP_SBC_1	1891:1895	Mutation rewiring degron network	0.1389
p.P3247L	RT4	urinary tract	COSMIC	ASSSS	DEG_SPOP_SBC_1	3245:3249	Mutation altering degron motif	0.7582
p.G3971S	HEC-1	endometrium	COSMIC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.2778
p.V1894I	DU-145	prostate	COSMIC	ASSSS	DEG_SPOP_SBC_1	1891:1895	Mutation altering degron motif	0.7076
p.S3258P	SNU-182	liver	COSMIC	ASSSS	DEG_SPOP_SBC_1	3245:3249	Mutation rewiring degron network	0.0833
p.T1475A	RERF-LC-Sq1	lung	COSMIC	IGTPTVT	DEG_SCF_FBW7_1	1466:1472	Mutation rewiring degron network	0.25
p.S671F	LU-139	lung	COSMIC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.25
p.M4073I	CCF-STTG1	central nervous system	COSMIC	ERDALFNID	DEG_APCC_DBOX_1	4075:4083	Mutation rewiring degron network	0.2778
p.P673L	COLO-792	skin	COSMIC	VSSTS	DEG_SPOP_SBC_1	664:668	Mutation rewiring degron network	0.1944
p.S1815P	EN	endometrium	COSMIC	VTSTS	DEG_SPOP_SBC_1	1801:1805	Mutation rewiring degron network	0.0556
p.T1148A	PWR-1E	prostate	COSMIC	VTSTS	DEG_SPOP_SBC_1	1139:1143	Mutation rewiring degron network	0.1944
p.P1038S	NCI-H1770	lung	COSMIC	VQSSS	DEG_SPOP_SBC_1	1045:1049	Mutation rewiring degron network	0.1389
p.F3637L	SNU-81	large intestine	COSMIC	DRKELSLVD	DEG_APCC_DBOX_1	3619:3627	Mutation rewiring degron network	0.0556
p.A1368S	Capan-2	pancreas	COSMIC	VTSTS	DEG_SPOP_SBC_1	1376:1380	Mutation rewiring degron network	0.1111
p.I847V	M059J	central nervous system	COSMIC	AVTST	DEG_SPOP_SBC_1	852:856	Mutation substituting flanking lysine	0.3056
p.P993Q	NB13	autonomic ganglia	COSMIC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation altering degron motif	0.7035
p.A984S	HEC-1	endometrium	COSMIC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.2222
p.G3971C	NCI-H1703	lung	COSMIC	KKENV	DEG_APCC_KENBOX_2	3973:3977	Mutation rewiring degron network	0.2778
p.S3913A	KYSE-450	oesophagus	COSMIC	PTPSSS	DEG_SCF_FBW7_1	3910:3915	Mutation altering degron motif	0.6477
p.V1003I	SNG-M	endometrium	COSMIC	TDQKTVPTP	DEG_COP1_1	988:996	Mutation rewiring degron network	0.1389
p.Q757R	MCC26	skin	COSMIC	VQSSS	DEG_SPOP_SBC_1	759:763	Mutation rewiring degron network	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

ALMS1

UniProt ID: Q8TCU4

Entrez ID: 7840

Protein name: Alstrom syndrome protein 1

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for ALMS1 in