DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_APCC_DBOX_1

Location: 3619:3627

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8668

ASA_SCORE: 85.4667

COIL: 0.4764

CONS_SCORE: 0.5852

DSS_SCORE: 0.3775

HELIX: 0.5054

FCONS_SCORE: 1.2368

RIG_SCORE: 0.7827

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R3630H	TCGA-AA-3967	COAD	TCGA	DRKELSLVD	DEG_APCC_DBOX_1	0.25
p.R3627G	TCGA-CR-7388	HNSC	TCGA	DRKELSLVD	DEG_APCC_DBOX_1	0.7568
p.R3630C	TCGA-EB-A550	SKCM	TCGA	DRKELSLVD	DEG_APCC_DBOX_1	0.25
p.R3630C	ACH-000750	Skin Cancer	CCLE	DRKELSLVD	DEG_APCC_DBOX_1	0.25
p.R3630C	ACH-000971	Colon/Colorectal Cancer	CCLE	DRKELSLVD	DEG_APCC_DBOX_1	0.25
p.D3610N	DO2943	BRCA	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	0.0833
p.R3627I	DO229022	LICA	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	0.8102
p.S3621I	DO229031	LICA	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	0.7341
p.D3610Y	DO229008	LICA	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	0.0833
p.V3617M	DO48587	LIHC	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	0.2778
p.R3635Q	DO23356	LINC	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	0.1111
p.R3635W	DO43306	UCEC	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	0.1111
p.R3635L	DO41847	UCEC	ICGC	DRKELSLVD	DEG_APCC_DBOX_1	0.1111
p.I3635L	SIDM00962	Chronic Myelogenous Leukemia	GDSC	DRKELSLVD	DEG_APCC_DBOX_1	0.1111
p.I3635L	BV-173	haematopoietic_and_lymphoid_tissue	COSMIC	DRKELSLVD	DEG_APCC_DBOX_1	0.1111
p.R3631C	SIDM00149	Melanoma	GDSC	DRKELSLVD	DEG_APCC_DBOX_1	0.2222
p.R3631C	SIDM00783	Colorectal Carcinoma	GDSC	DRKELSLVD	DEG_APCC_DBOX_1	0.2222
p.R3631C	HCT-116	large_intestine	COSMIC	DRKELSLVD	DEG_APCC_DBOX_1	0.2222
p.R3631C	LOXIMVI	skin	COSMIC	DRKELSLVD	DEG_APCC_DBOX_1	0.2222
p.I3634L	ACH-000432	Leukemia	CCLE	DRKELSLVD	DEG_APCC_DBOX_1	0.25
p.Q3611L	ACH-001396	Metastasis	CCLE	DRKELSLVD	DEG_APCC_DBOX_1	0.1111
p.F3637L	SNU-81	large_intestine	COSMIC	DRKELSLVD	DEG_APCC_DBOX_1	0.0556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_APCC_DBOX_1	3619:3627	DRKELSLVD	APC,CDC20,FZR1	0.8668	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons