DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_COP1_1

Location: 988:996

E3 ligase: COP1

DEGRON score: 0.9966

ASA_SCORE: 99.4556

COIL: 0.9309

CONS_SCORE: 0.5452

DSS_SCORE: 0.5936

HELIX: 0.0203

FCONS_SCORE: 1.0788

RIG_SCORE: 0.6689

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P998L	TCGA-FW-A3R5	SKCM	TCGA	TDQKTVPTP	DEG_COP1_1	0.2778
p.P998L	DO37406	SKCM	ICGC	TDQKTVPTP	DEG_COP1_1	0.2778
p.I999L	DO222601	ESCA	ICGC	TDQKTVPTP	DEG_COP1_1	0.25
p.P1000Q	DO37770	SKCM	ICGC	TDQKTVPTP	DEG_COP1_1	0.2222
p.L984P	DO51795	STAD	ICGC	TDQKTVPTP	DEG_COP1_1	0.2222
p.S1000L	SIDM00381	Cervical Carcinoma	GDSC	TDQKTVPTP	DEG_COP1_1	0.2222
p.S1000L	SKG-IIIa	cervix	COSMIC	TDQKTVPTP	DEG_COP1_1	0.2222
p.S999L	ACH-002020	Cervical Cancer	CCLE	TDQKTVPTP	DEG_COP1_1	0.25
p.P993Q	NB13	autonomic_ganglia	COSMIC	TDQKTVPTP	DEG_COP1_1	0.7035
p.A984S	HEC-1	endometrium	COSMIC	TDQKTVPTP	DEG_COP1_1	0.2222
p.V1003I	SNG-M	endometrium	COSMIC	TDQKTVPTP	DEG_COP1_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8TCU4	Alstrom syndrome protein 1	DEG_COP1_1	988:996	TDQKTVPTP	COP1	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons