DegronMD

Uniprot ID: Q8TCU4

Source protein: Alstrom syndrome protein 1

Source gene: ALMS1

Class: DEG_SPOP_SBC_1

Location: 570:574

E3 ligase: SPOP

DEGRON score: 0.9598

ASA_SCORE: 85.12

COIL: 0.8968

CONS_SCORE: 0.2738

DSS_SCORE: 0.6461

HELIX: 0.031

FCONS_SCORE: 1

RIG_SCORE: 0.6302

Degron related mutations and impact score

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H574Y	ACH-000543	Brain Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	0.7229
p.H576Q	DO6392	CLLE	ICGC	VLSSS	DEG_SPOP_SBC_1	0.7222
p.S573G	SIDM01172	Acute Myeloid Leukemia	GDSC	VLSSS	DEG_SPOP_SBC_1	0.6993
p.S572G	ACH-000146	Leukemia	CCLE	VLSSS	DEG_SPOP_SBC_1	0.6993
p.S573P	TCGA-12-0829	GBM	TCGA	VLSSS	DEG_SPOP_SBC_1	0.6752
p.S573P	TCGA-23-1032	OV	TCGA	VLSSS	DEG_SPOP_SBC_1	0.6752
p.S573P	DO11166	GBM	ICGC	VLSSS	DEG_SPOP_SBC_1	0.6752
p.S573P	DO32267	OV	ICGC	VLSSS	DEG_SPOP_SBC_1	0.6752
p.S572T	TCGA-12-0829	GBM	TCGA	VLSSS	DEG_SPOP_SBC_1	0.6005
p.S572T	TCGA-23-1032	OV	TCGA	VLSSS	DEG_SPOP_SBC_1	0.6005
p.S572T	DO11166	GBM	ICGC	VLSSS	DEG_SPOP_SBC_1	0.6005
p.S572T	DO32267	OV	ICGC	VLSSS	DEG_SPOP_SBC_1	0.6005
p.V569I	TCGA-ZB-A96A	THYM	TCGA	VLSSS	DEG_SPOP_SBC_1	0.3056
p.H575Y	SIDM01446	Glioblastoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.3056
p.R577K	ACH-001610	Brain Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	0.25
p.T566I	TCGA-B5-A11H	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	0.2222
p.T566I	DO42825	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2222
p.G578R	TCGA-FI-A2F4	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	0.2222
p.G578R	DO43434	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2222
p.T566K	DO234160	ESAD	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2222
p.S578F	DO219501	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2222

Showing 1 to 21 of 21 entries

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Drug responses associated with ALMS1 mutations

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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All proteins holding degron of VLSSS

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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1175:1179	VLSSS	SPOP	0.9697	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	291:295	VLSSS	SPOP	0.9986	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	570:574	VLSSS	SPOP	0.9598	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	526:530	VLSSS	SPOP	0.911	More...
Q9H329	Band 4.1-like protein 4B	DEG_SPOP_SBC_1	477:481	VLSSS	SPOP	0.9088	More...
Q6UUV7	CREB-regulated transcription coactivator 3	DEG_SPOP_SBC_1	341:345	VLSSS	SPOP	0.9871	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	687:691	VLSSS	SPOP	0.9973	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	430:434	VLSSS	SPOP	0.99	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	177:181	VLSSS	SPOP	0.8195	More...
O00182	Galectin-9	DEG_SPOP_SBC_1	37:41	VLSSS	SPOP	0.6739	More...
Q3B8N2	Galectin-9B	DEG_SPOP_SBC_1	37:41	VLSSS	SPOP	0.6051	More...
Q8WUI4	Histone deacetylase 7	DEG_SPOP_SBC_1	505:509	VLSSS	SPOP	0.9515	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	665:669	VLSSS	SPOP	0.888	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	254:258	VLSSS	SPOP	0.9995	More...
Q15149	Plectin	DEG_SPOP_SBC_1	978:982	VLSSS	SPOP	0.6246	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	225:229	VLSSS	SPOP	0.993	More...
Q14671	Pumilio homolog 1	DEG_SPOP_SBC_1	225:229	VLSSS	SPOP	0.9888	More...
Q8TB72	Pumilio homolog 2	DEG_SPOP_SBC_1	98:102	VLSSS	SPOP	0.9847	More...
Q96QF0	Rab-3A-interacting protein	DEG_SPOP_SBC_1	259:263	VLSSS	SPOP	0.9939	More...
Q6IAA8	Ragulator complex protein LAMTOR1	DEG_SPOP_SBC_1	94:98	VLSSS	SPOP	0.5049	More...
P98175	RNA-binding protein 10	DEG_SPOP_SBC_1	325:329	VLSSS	SPOP	0.7807	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1894:1898	VLSSS	SPOP	0.9125	More...
A6NMB1	Sialic acid-binding Ig-like lectin 16	DEG_SPOP_SBC_1	277:281	VLSSS	SPOP	0.7762	More...
Q07890	Son of sevenless homolog 2	DEG_SPOP_SBC_1	1276:1280	VLSSS	SPOP	0.9839	More...
Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	DEG_SPOP_SBC_1	854:858	VLSSS	SPOP	0.893	More...

Showing 1 to 25 of 32 entries

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DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLSSS

Degron related mutations and impact score

Drug responses associated with ALMS1 mutations

All proteins holding degron of VLSSS