DegronMD: protein-targeted degradation, mutation and drug response to degrons
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CGC
Degron:
VLSSS
Uniprot ID:
Q8TCU4
Source protein:
Alstrom syndrome protein 1
Source gene:
ALMS1
Class:
DEG_SPOP_SBC_1
Location:
570:574
E3 ligase:
SPOP
DEGRON score:
0.9598
ASA_SCORE:
85.12
COIL:
0.8968
CONS_SCORE:
0.2738
DSS_SCORE:
0.6461
HELIX:
0.031
FCONS_SCORE:
1
RIG_SCORE:
0.6302
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S572T
TCGA-12-0829
GBM
TCGA
VLSSS
DEG_SPOP_SBC_1
0.6005
p.S572T
TCGA-23-1032
OV
TCGA
VLSSS
DEG_SPOP_SBC_1
0.6005
p.S572T
DO11166
GBM
ICGC
VLSSS
DEG_SPOP_SBC_1
0.6005
p.S572T
DO32267
OV
ICGC
VLSSS
DEG_SPOP_SBC_1
0.6005
p.S573P
TCGA-12-0829
GBM
TCGA
VLSSS
DEG_SPOP_SBC_1
0.6752
p.S573P
TCGA-23-1032
OV
TCGA
VLSSS
DEG_SPOP_SBC_1
0.6752
p.S573P
DO11166
GBM
ICGC
VLSSS
DEG_SPOP_SBC_1
0.6752
p.S573P
DO32267
OV
ICGC
VLSSS
DEG_SPOP_SBC_1
0.6752
p.T566I
TCGA-B5-A11H
UCEC
TCGA
VLSSS
DEG_SPOP_SBC_1
0.2222
p.T566I
DO42825
UCEC
ICGC
VLSSS
DEG_SPOP_SBC_1
0.2222
p.G578R
TCGA-FI-A2F4
UCEC
TCGA
VLSSS
DEG_SPOP_SBC_1
0.2222
p.G578R
DO43434
UCEC
ICGC
VLSSS
DEG_SPOP_SBC_1
0.2222
p.V569I
TCGA-ZB-A96A
THYM
TCGA
VLSSS
DEG_SPOP_SBC_1
0.3056
p.H576Q
DO6392
CLLE
ICGC
VLSSS
DEG_SPOP_SBC_1
0.7222
p.T566K
DO234160
ESAD
ICGC
VLSSS
DEG_SPOP_SBC_1
0.2222
p.S578F
DO219501
SKCM
ICGC
VLSSS
DEG_SPOP_SBC_1
0.2222
p.S573G
SIDM01172
Acute Myeloid Leukemia
GDSC
VLSSS
DEG_SPOP_SBC_1
0.6993
p.H575Y
SIDM01446
Glioblastoma
GDSC
VLSSS
DEG_SPOP_SBC_1
0.3056
p.S572G
ACH-000146
Leukemia
CCLE
VLSSS
DEG_SPOP_SBC_1
0.6993
p.H574Y
ACH-000543
Brain Cancer
CCLE
VLSSS
DEG_SPOP_SBC_1
0.7229
p.R577K
ACH-001610
Brain Cancer
CCLE
VLSSS
DEG_SPOP_SBC_1
0.25
Drug responses associated with ALMS1 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of VLSSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
O00182
Galectin-9
DEG_SPOP_SBC_1
37:41
VLSSS
SPOP
0.6739
More...
O00268
Transcription initiation factor TFIID subunit 4
DEG_SPOP_SBC_1
697:701
VLSSS
SPOP
0.7112
More...
O75113
NEDD4-binding protein 1
DEG_SPOP_SBC_1
254:258
VLSSS
SPOP
0.9995
More...
P19484
Transcription factor EB
DEG_SPOP_SBC_1
130:134
VLSSS
SPOP
0.9904
More...
P25054
Adenomatous polyposis coli protein
DEG_SPOP_SBC_1
291:295
VLSSS
SPOP
0.9986
More...
P98175
RNA-binding protein 10
DEG_SPOP_SBC_1
325:329
VLSSS
SPOP
0.7807
More...
Q07890
Son of sevenless homolog 2
DEG_SPOP_SBC_1
1276:1280
VLSSS
SPOP
0.9839
More...
Q14671
Pumilio homolog 1
DEG_SPOP_SBC_1
225:229
VLSSS
SPOP
0.9888
More...
Q15149
Plectin
DEG_SPOP_SBC_1
978:982
VLSSS
SPOP
0.6246
More...
Q15572
TATA box-binding protein-associated factor RNA polymerase I subunit C
DEG_SPOP_SBC_1
854:858
VLSSS
SPOP
0.893
More...
Q6IAA8
Ragulator complex protein LAMTOR1
DEG_SPOP_SBC_1
94:98
VLSSS
SPOP
0.5049
More...
Q6UUV7
CREB-regulated transcription coactivator 3
DEG_SPOP_SBC_1
341:345
VLSSS
SPOP
0.9871
More...
Q86WP2
Vasculin
DEG_SPOP_SBC_1
377:381
VLSSS
SPOP
0.9365
More...
Q8NDX5
Polyhomeotic-like protein 3
DEG_SPOP_SBC_1
225:229
VLSSS
SPOP
0.993
More...
Q8TB72
Pumilio homolog 2
DEG_SPOP_SBC_1
98:102
VLSSS
SPOP
0.9847
More...
Q8TCU4
Alstrom syndrome protein 1
DEG_SPOP_SBC_1
570:574
VLSSS
SPOP
0.9598
More...
Q8WUI4
Histone deacetylase 7
DEG_SPOP_SBC_1
505:509
VLSSS
SPOP
0.9515
More...
Q96EB6
NAD-dependent protein deacetylase sirtuin-1
DEG_SPOP_SBC_1
665:669
VLSSS
SPOP
0.888
More...
Q96IT1
Zinc finger protein 496
DEG_SPOP_SBC_1
356:360
VLSSS
SPOP
0.6662
More...
Q96P47
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3
DEG_SPOP_SBC_1
526:530
VLSSS
SPOP
0.911
More...
Q96QF0
Rab-3A-interacting protein
DEG_SPOP_SBC_1
259:263
VLSSS
SPOP
0.9939
More...
Q9H329
Band 4.1-like protein 4B
DEG_SPOP_SBC_1
477:481
VLSSS
SPOP
0.9088
More...
Q9H4A3
Serine/threonine-protein kinase WNK1
DEG_SPOP_SBC_1
1894:1898
VLSSS
SPOP
0.9125
More...
Q9NS91
E3 ubiquitin-protein ligase RAD18
DEG_SPOP_SBC_1
430:434
VLSSS
SPOP
0.99
More...
Q9P212
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
DEG_SPOP_SBC_1
1175:1179
VLSSS
SPOP
0.9697
More...
Q9UKG1
DCC-interacting protein 13-alpha
DEG_SPOP_SBC_1
687:691
VLSSS
SPOP
0.9973
More...
Q9Y2X9
Zinc finger protein 281
DEG_SPOP_SBC_1
77:81
VLSSS
SPOP
0.9826
More...
A6NMB1
Sialic acid-binding Ig-like lectin 16
DEG_SPOP_SBC_1
277:281
VLSSS
SPOP
0.7762
More...
P17098
Zinc finger protein 8
DEG_SPOP_SBC_1
183:187
VLSSS
SPOP
0.9973
More...
Q3B8N2
Galectin-9B
DEG_SPOP_SBC_1
37:41
VLSSS
SPOP
0.6051
More...
Q8N442
Translation factor GUF1, mitochondrial
DEG_SPOP_SBC_1
437:441
VLSSS
SPOP
0.5017
More...
Q6ZVF9
G protein-regulated inducer of neurite outgrowth 3
DEG_SPOP_SBC_1
177:181
VLSSS
SPOP
0.8195
More...