DegronMD - Q6UUV7(CRTC3)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.Q422K	TCGA-66-2791	LUSC	TCGA	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1944
p.Q422K	DO26435	LUSC	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.1944
p.R428Q	TCGA-A5-A0G2	UCEC	TCGA	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.7329
p.R428Q	DO233823	GACA	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.7329
p.R428Q	DO41235	UCEC	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.7329
p.S425F	TCGA-BS-A0VI	UCEC	TCGA	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2778
p.S425F	DO41764	UCEC	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.2778
p.P350S	TCGA-DK-A1AC	BLCA	TCGA	VLSSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1944
p.P350S	DO514	BLCA	ICGC	VLSSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1944
p.P331H	TCGA-EL-A3GU	THCA	TCGA	VLSSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.0556
p.P331H	DO40411	THCA	ICGC	VLSSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.0556
p.P444Q	DO222626	BTCA	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation rewiring degron network	0.0833
p.P444Q	DO222626	BTCA	ICGC	PPPY	ITCH	445:448	Mutation rewiring degron network	0.3056
p.S343F	DO220891	MELA	ICGC	VLSSS	DEG_SPOP_SBC_1	341:345	Mutation altering degron motif	0.7982
p.P457S	DO220906	MELA	ICGC	PPPY	ITCH	445:448	Mutation rewiring degron network	0.0833
p.L431V	SIDM01173	Rhabdomyosarcoma	GDSC	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.6765
p.L431V	TE-441-T	soft tissue	COSMIC	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation altering degron motif	0.6765
p.S443L	SIDM01608	Endometrial Carcinoma	GDSC	DRSQLSFLP	DEG_APCC_DBOX_1	427:435	Mutation blocking phosphorylation signal	0.5556
p.S443L	SIDM01608	Endometrial Carcinoma	GDSC	PPPY	ITCH	445:448	Mutation blocking phosphorylation signal	0.7222
p.T336M	SIDM01451	Pancreatic Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1944
p.T336M	ACH-000933	Pancreatic Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.1944
p.P331T	ACH-001610	Brain Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	341:345	Mutation rewiring degron network	0.0556

Kaplan plot for CRTC3 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

CRTC3

UniProt ID: Q6UUV7

Entrez ID: 64784

Protein name: CREB-regulated transcription coactivator 3 (Transducer of regulated cAMP response element-binding protein 3) (TORC-3) (Transducer of CREB protein 3)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for CRTC3 in