DegronMD

Uniprot ID: Q6UUV7

Source protein: CREB-regulated transcription coactivator 3

Source gene: CRTC3

Class: DEG_APCC_DBOX_1

Location: 427:435

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.9892

ASA_SCORE: 94.3111

COIL: 0.844

CONS_SCORE: 0.444

DSS_SCORE: 0.6138

HELIX: 0.1376

FCONS_SCORE: 1.0787

RIG_SCORE: 0.6662

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.Q422K	TCGA-66-2791	LUSC	TCGA	DRSQLSFLP	DEG_APCC_DBOX_1	0.1944
p.Q422K	DO26435	LUSC	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	0.1944
p.R428Q	TCGA-A5-A0G2	UCEC	TCGA	DRSQLSFLP	DEG_APCC_DBOX_1	0.7329
p.R428Q	DO233823	GACA	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	0.7329
p.R428Q	DO41235	UCEC	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	0.7329
p.S425F	TCGA-BS-A0VI	UCEC	TCGA	DRSQLSFLP	DEG_APCC_DBOX_1	0.2778
p.S425F	DO41764	UCEC	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	0.2778
p.P444Q	DO222626	BTCA	ICGC	DRSQLSFLP	DEG_APCC_DBOX_1	0.0833
p.L431V	SIDM01173	Rhabdomyosarcoma	GDSC	DRSQLSFLP	DEG_APCC_DBOX_1	0.6765
p.L431V	TE-441-T	soft_tissue	COSMIC	DRSQLSFLP	DEG_APCC_DBOX_1	0.6765
p.S443L	SIDM01608	Endometrial Carcinoma	GDSC	DRSQLSFLP	DEG_APCC_DBOX_1	0.5556

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q6UUV7	CREB-regulated transcription coactivator 3	DEG_APCC_DBOX_1	427:435	DRSQLSFLP	APC,CDC20,FZR1	0.9892	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons