DegronMD

Uniprot ID: Q96EB6

Source protein: NAD-dependent protein deacetylase sirtuin-1

Source gene: SIRT1

Class: DEG_SPOP_SBC_1

Location: 665:669

E3 ligase: SPOP

DEGRON score: 0.888

ASA_SCORE: 83.38

COIL: 0.7972

CONS_SCORE: 0.2835

DSS_SCORE: 0.5502

HELIX: 0.1804

FCONS_SCORE: 0.9012

RIG_SCORE: 0.6565

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V665I	TCGA-AX-A0J1	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	0.7076
p.V665I	TCGA-FI-A2D0	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	0.7076
p.A655T	TCGA-AX-A2HD	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	0.0556
p.S675N	TCGA-AZ-4315	COAD	TCGA	VLSSS	DEG_SPOP_SBC_1	0.1667
p.S669G	TCGA-D7-6521	STAD	TCGA	VLSSS	DEG_SPOP_SBC_1	0.8104
p.S668F	SIDM02042	Pancreatic Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.7982
p.S668F	SIDM00895	B-Cell Non-Hodgkin's Lymphoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.7982
p.S668F	ACH-002215	Lymphoma	CCLE	VLSSS	DEG_SPOP_SBC_1	0.7982
p.S668F	BC-3	haematopoietic_and_lymphoid_tissue	COSMIC	VLSSS	DEG_SPOP_SBC_1	0.7982
p.S673G	SIDM01608	Endometrial Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.2222
p.S673G	ACH-000990	Endometrial/Uterine Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	0.2222
p.E662D	SIDM01617	Endometrial Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	0.25
p.E662D	ACH-000994	Endometrial/Uterine Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	0.25

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
SIDM00841	COREAD\|large_intestine	p.V383I (No)	GDSC	Selisistat	234.3646
SIDM00951	LAML\|acute_myeloid_leukaemia	p.L478V (No)	GDSC	Selisistat	77.29
SIDM00782	COREAD\|large_intestine	p.D379N (No)	GDSC	Selisistat	339.5601
SIDM01007	ALL\|lymphoblastic_leukemia	p.I256fs*2 (No)	GDSC	Selisistat	87.1222
SIDM00145	ALL\|lymphoblastic_leukemia	p.F414fs*13 (No)	GDSC	Selisistat	125.1844
SIDM00619	THCA\|thyroid	p.G355V (No)	GDSC	Selisistat	79.5472
SIDM00770	SCLC\|lung_small_cell_carcinoma	p.G495D (No)	GDSC	Selisistat	367.6381
SIDM00304	OV\|ovary	p.S324fs*8 (No)	GDSC	Selisistat	447.8266
SIDM00602	STAD\|stomach	p.R237fs*11 (No)	GDSC	Selisistat	298.1516
SIDM00783	COREAD\|large_intestine	p.I256fs*2 (No)	GDSC	Selisistat	142.6314
SIDM00898	BRCA\|breast	p.T177I (No)	GDSC	Selisistat	287.6047
SIDM00685	GBM\|glioma	p.P393R (No)	GDSC	Selisistat	131.2062
SIDM00150	COREAD\|large_intestine	p.M407T (No)	GDSC	Selisistat	170.1144
SIDM00375	HNSC\|head_and_neck	p.A712T (No)	GDSC	Selisistat	325.9115
SIDM00789	COREAD\|large_intestine	p.R181W (No)	GDSC	Selisistat	198.5977
SIDM01154	ALL\|lymphoblastic_T_cell_leukaemia	p.F414fs*13 (No)	GDSC	Selisistat	112.6936
SIDM00895	DLBC\|B_cell_lymphoma	p.S668F (Yes)	GDSC	Selisistat	124.056
SIDM01081	HNSC\|head_and_neck	p.I270K (No)	GDSC	Selisistat	292.294
SIDM00299	UNCLASSIFIED\|soft_tissue_other	p.A712T (No)	GDSC	Selisistat	332.9169
SIDM00447	UNCLASSIFIED\|B_cell_leukemia	p.R649H (No)	GDSC	Selisistat	156.663
SIDM00193	COREAD\|large_intestine	p.K238T (No)	GDSC	Selisistat	474.4698
SIDM00193	COREAD\|large_intestine	p.E725G (No)	GDSC	Selisistat	474.4698
SIDM00118	COREAD\|large_intestine	p.E520* (No)	GDSC	Selisistat	256.5652
SIDM00118	COREAD\|large_intestine	p.E687K (No)	GDSC	Selisistat	256.5652

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00182	Galectin-9	DEG_SPOP_SBC_1	37:41	VLSSS	SPOP	0.6739	More...
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	697:701	VLSSS	SPOP	0.7112	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	254:258	VLSSS	SPOP	0.9995	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	130:134	VLSSS	SPOP	0.9904	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	291:295	VLSSS	SPOP	0.9986	More...
P98175	RNA-binding protein 10	DEG_SPOP_SBC_1	325:329	VLSSS	SPOP	0.7807	More...
Q07890	Son of sevenless homolog 2	DEG_SPOP_SBC_1	1276:1280	VLSSS	SPOP	0.9839	More...
Q14671	Pumilio homolog 1	DEG_SPOP_SBC_1	225:229	VLSSS	SPOP	0.9888	More...
Q15149	Plectin	DEG_SPOP_SBC_1	978:982	VLSSS	SPOP	0.6246	More...
Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	DEG_SPOP_SBC_1	854:858	VLSSS	SPOP	0.893	More...
Q6IAA8	Ragulator complex protein LAMTOR1	DEG_SPOP_SBC_1	94:98	VLSSS	SPOP	0.5049	More...
Q6UUV7	CREB-regulated transcription coactivator 3	DEG_SPOP_SBC_1	341:345	VLSSS	SPOP	0.9871	More...
Q86WP2	Vasculin	DEG_SPOP_SBC_1	377:381	VLSSS	SPOP	0.9365	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	225:229	VLSSS	SPOP	0.993	More...
Q8TB72	Pumilio homolog 2	DEG_SPOP_SBC_1	98:102	VLSSS	SPOP	0.9847	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	570:574	VLSSS	SPOP	0.9598	More...
Q8WUI4	Histone deacetylase 7	DEG_SPOP_SBC_1	505:509	VLSSS	SPOP	0.9515	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	665:669	VLSSS	SPOP	0.888	More...
Q96IT1	Zinc finger protein 496	DEG_SPOP_SBC_1	356:360	VLSSS	SPOP	0.6662	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	526:530	VLSSS	SPOP	0.911	More...
Q96QF0	Rab-3A-interacting protein	DEG_SPOP_SBC_1	259:263	VLSSS	SPOP	0.9939	More...
Q9H329	Band 4.1-like protein 4B	DEG_SPOP_SBC_1	477:481	VLSSS	SPOP	0.9088	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1894:1898	VLSSS	SPOP	0.9125	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	430:434	VLSSS	SPOP	0.99	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1175:1179	VLSSS	SPOP	0.9697	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	687:691	VLSSS	SPOP	0.9973	More...
Q9Y2X9	Zinc finger protein 281	DEG_SPOP_SBC_1	77:81	VLSSS	SPOP	0.9826	More...
A6NMB1	Sialic acid-binding Ig-like lectin 16	DEG_SPOP_SBC_1	277:281	VLSSS	SPOP	0.7762	More...
P17098	Zinc finger protein 8	DEG_SPOP_SBC_1	183:187	VLSSS	SPOP	0.9973	More...
Q3B8N2	Galectin-9B	DEG_SPOP_SBC_1	37:41	VLSSS	SPOP	0.6051	More...
Q8N442	Translation factor GUF1, mitochondrial	DEG_SPOP_SBC_1	437:441	VLSSS	SPOP	0.5017	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	177:181	VLSSS	SPOP	0.8195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLSSS

Degron related mutations and impact score

Drug responses associated with SIRT1 mutations

All proteins holding degron of VLSSS