DegronMD - Q07890(SOS2)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.T1254M	TCGA-19-5956	GBM	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1944
p.T1254M	TCGA-AX-A2HC	UCEC	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1944
p.T1254M	DO13863	GBM	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1944
p.T1254M	DO41572	UCEC	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1944
p.T1254M	SIDM00781	Colorectal Carcinoma	GDSC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1944
p.T1254M	SIDM00780	Colorectal Carcinoma	GDSC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1944
p.T1254M	SNU-C2B	large intestine	COSMIC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1944
p.R1273Q	TCGA-49-AARE	LUAD	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1111
p.R1273Q	TCGA-49-AARE	LUAD	TCGA	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.25
p.R1273Q	TCGA-AB-2828	LAML	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1111
p.R1273Q	TCGA-AB-2828	LAML	TCGA	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.25
p.R1273Q	DO21571	LAML	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1111
p.R1273Q	DO21571	LAML	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.25
p.R1273Q	DO218922	LUAD	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1111
p.R1273Q	DO218922	LUAD	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.25
p.R1273L	TCGA-56-5898	LUSC	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1111
p.R1273L	TCGA-56-5898	LUSC	TCGA	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.25
p.R1273L	DO26548	LUSC	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1111
p.R1273L	DO26548	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.25
p.P1263S	TCGA-A6-6653	COAD	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation altering degron motif	0.5641
p.P1263S	DO10373	COAD	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation altering degron motif	0.5641
p.P1287H	TCGA-AP-A059	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1389
p.P1287H	DO41361	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1389
p.R1272C	TCGA-AX-A2HG	UCEC	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1389
p.R1272C	TCGA-AX-A2HG	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.R1272C	TCGA-BS-A0TA	UCEC	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1389
p.R1272C	TCGA-BS-A0TA	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.R1272C	DO43298	UCEC	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1389
p.R1272C	DO43298	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.R1272C	DO41337	UCEC	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1389
p.R1272C	DO41337	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.P1083Q	TCGA-CV-7434	HNSC	TCGA	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1667
p.P1083Q	DO15831	HNSC	ICGC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1667
p.P1089Q	TCGA-D3-A1QA	SKCM	TCGA	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation altering degron motif	0.7035
p.P1089Q	DO47469	SKCM	ICGC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation altering degron motif	0.7035
p.P1263A	TCGA-DQ-5631	HNSC	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation altering degron motif	0.6392
p.P1263A	DO14175	HNSC	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation altering degron motif	0.6392
p.A1082P	TCGA-DS-A0VL	CESC	TCGA	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1389
p.A1082P	DO6332	CESC	ICGC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1389
p.L1100I	TCGA-FS-A1ZR	SKCM	TCGA	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1944
p.L1100I	DO37651	SKCM	ICGC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1944
p.Y1310C	TCGA-G2-A3IE	BLCA	TCGA	PPLY	ITCH	1317:1320	Mutation rewiring degron network	0.1389
p.Y1310C	DO767	BLCA	ICGC	PPLY	ITCH	1317:1320	Mutation rewiring degron network	0.1389
p.P1271Q	TCGA-HE-7128	KIRP	TCGA	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1667
p.P1271Q	TCGA-HE-7128	KIRP	TCGA	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1944
p.P1271Q	DO20796	KIRP	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1667
p.P1271Q	DO20796	KIRP	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1944
p.Q1281H	TCGA-L9-A743	LUAD	TCGA	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.3056
p.Q1281H	DO48384	BLCA	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.3056
p.Q1281H	DO49874	LUAD	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.3056
p.S1098L	TCGA-LN-A8I1	ESCA	TCGA	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.25
p.Y1320H	DO48266	ESCA	ICGC	PPLY	ITCH	1317:1320	Mutation altering degron motif	0.834
p.N1327S	DO231963	LICA	ICGC	PPLY	ITCH	1317:1320	Mutation rewiring degron network	0.1389
p.A1096D	DO228978	LICA	ICGC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.3056
p.H1286N	DO228986	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1667
p.T1084N	DO229028	LICA	ICGC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1944
p.T1084N	DO229036	LICA	ICGC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1944
p.A1328E	DO229031	LICA	ICGC	PPLY	ITCH	1317:1320	Mutation rewiring degron network	0.1111
p.P1271T	DO229045	LICA	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1667
p.P1271T	DO229045	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1944
p.P1271T	DO229008	LICA	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1667
p.P1271T	DO229008	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1944
p.R1272S	DO229060	LICA	ICGC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.1389
p.R1272S	DO229060	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.2222
p.F1103L	SIDM00545	Melanoma	GDSC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1111
p.F1103L	Mewo	skin	COSMIC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1111
p.L1277P	SIDM00111	Glioma	GDSC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation altering degron motif	0.6471
p.L1277P	SIDM01191	Osteosarcoma	GDSC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation altering degron motif	0.6471
p.L1277P	U251	central nervous system	COSMIC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation altering degron motif	0.6471
p.L1277P	U-2-OS	bone	COSMIC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation altering degron motif	0.6471
p.P1318S	SIDM00009	Acute Myeloid Leukemia	GDSC	PPLY	ITCH	1317:1320	Mutation altering degron motif	0.6752
p.P1318S	SIDM00739	Non-Small Cell Lung Carcinoma	GDSC	PPLY	ITCH	1317:1320	Mutation altering degron motif	0.6752
p.P1318S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PPLY	ITCH	1317:1320	Mutation altering degron motif	0.6752
p.T1079A	SIDM01716	Non-Cancerous	GDSC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.0556
p.T1079A	SIDM00175	Melanoma	GDSC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.0556
p.T1079A	SIDM01135	Pancreatic Carcinoma	GDSC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.0556
p.T1079A	PANC-10-05	pancreas	COSMIC	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.0556
p.P1318L	SIDM00282	Colorectal Carcinoma	GDSC	PPLY	ITCH	1317:1320	Mutation altering degron motif	0.7582
p.P1318L	CW-2	large intestine	COSMIC	PPLY	ITCH	1317:1320	Mutation altering degron motif	0.7582
p.N1257D	SIDM00936	Bladder Carcinoma	GDSC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.2778
p.N1257D	CAL-29	urinary tract	COSMIC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation rewiring degron network	0.2778
p.G1101C	ACH-000954	Endometrial/Uterine Cancer	CCLE	PSTPPVS	DEG_SCF_FBW7_1	1089:1095	Mutation rewiring degron network	0.1667
p.P1285L	ACH-000998	Colon/Colorectal Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1944
p.P1285L	CW-2	large intestine	COSMIC	VLSSS	DEG_SPOP_SBC_1	1276:1280	Mutation rewiring degron network	0.1944
p.P1260L	ACH-002309	Sarcoma	CCLE	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation altering degron motif	0.7582
p.P1260L	SW684	soft tissue	COSMIC	PSTPPST	DEG_SCF_FBW7_1	1259:1265	Mutation altering degron motif	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SOS2

UniProt ID: Q07890

Entrez ID: 6655

Protein name: Son of sevenless homolog 2 (SOS-2)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for SOS2 in