DegronMD

Uniprot ID: Q07890

Source protein: Son of sevenless homolog 2

Source gene: SOS2

Class: DEG_SCF_FBW7_1

Location: 1259:1265

E3 ligase: FBXW7

DEGRON score: 0.7292

ASA_SCORE: 94.9

COIL: 0.9791

CONS_SCORE: 0.2467

DSS_SCORE: 0.6546

HELIX: 0.0069

FCONS_SCORE: 0.9987

RIG_SCORE: 0.5191

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1254M	TCGA-19-5956	GBM	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.1944
p.T1254M	TCGA-AX-A2HC	UCEC	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.1944
p.T1254M	DO13863	GBM	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1944
p.T1254M	DO41572	UCEC	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1944
p.T1254M	SIDM00781	Colorectal Carcinoma	GDSC	PSTPPST	DEG_SCF_FBW7_1	0.1944
p.T1254M	SIDM00780	Colorectal Carcinoma	GDSC	PSTPPST	DEG_SCF_FBW7_1	0.1944
p.T1254M	SNU-C2B	large_intestine	COSMIC	PSTPPST	DEG_SCF_FBW7_1	0.1944
p.R1273Q	TCGA-49-AARE	LUAD	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.1111
p.R1273Q	TCGA-AB-2828	LAML	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.1111
p.R1273Q	DO21571	LAML	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1111
p.R1273Q	DO218922	LUAD	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1111
p.R1273L	TCGA-56-5898	LUSC	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.1111
p.R1273L	DO26548	LUSC	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1111
p.P1263S	TCGA-A6-6653	COAD	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.5641
p.P1263S	DO10373	COAD	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.5641
p.R1272C	TCGA-AX-A2HG	UCEC	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.1389
p.R1272C	TCGA-BS-A0TA	UCEC	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.1389
p.R1272C	DO43298	UCEC	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1389
p.R1272C	DO41337	UCEC	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1389
p.P1263A	TCGA-DQ-5631	HNSC	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.6392
p.P1263A	DO14175	HNSC	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.6392
p.P1271Q	TCGA-HE-7128	KIRP	TCGA	PSTPPST	DEG_SCF_FBW7_1	0.1667
p.P1271Q	DO20796	KIRP	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1667
p.P1271T	DO229045	LICA	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1667
p.P1271T	DO229008	LICA	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1667
p.R1272S	DO229060	LICA	ICGC	PSTPPST	DEG_SCF_FBW7_1	0.1389
p.N1257D	SIDM00936	Bladder Carcinoma	GDSC	PSTPPST	DEG_SCF_FBW7_1	0.2778
p.N1257D	CAL-29	urinary_tract	COSMIC	PSTPPST	DEG_SCF_FBW7_1	0.2778
p.P1260L	ACH-002309	Sarcoma	CCLE	PSTPPST	DEG_SCF_FBW7_1	0.7582
p.P1260L	SW684	soft_tissue	COSMIC	PSTPPST	DEG_SCF_FBW7_1	0.7582

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PSTPPST

Degron related mutations and impact score

Drug responses associated with SOS2 mutations

All proteins holding degron of PSTPPST

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07890	Son of sevenless homolog 2	DEG_SCF_FBW7_1	1259:1265	PSTPPST	FBXW7	0.7292	More...