DegronMD

Uniprot ID: Q07890

Source protein: Son of sevenless homolog 2

Source gene: SOS2

Class: DEG_SCF_FBW7_1

Location: 1089:1095

E3 ligase: FBXW7

DEGRON score: 0.9246

ASA_SCORE: 87.5714

COIL: 0.96

CONS_SCORE: 0.2291

DSS_SCORE: 0.5648

HELIX: 0.0193

FCONS_SCORE: 0.9887

RIG_SCORE: 0.6239

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1083Q	TCGA-CV-7434	HNSC	TCGA	PSTPPVS	DEG_SCF_FBW7_1	0.1667
p.P1083Q	DO15831	HNSC	ICGC	PSTPPVS	DEG_SCF_FBW7_1	0.1667
p.P1089Q	TCGA-D3-A1QA	SKCM	TCGA	PSTPPVS	DEG_SCF_FBW7_1	0.7035
p.P1089Q	DO47469	SKCM	ICGC	PSTPPVS	DEG_SCF_FBW7_1	0.7035
p.A1082P	TCGA-DS-A0VL	CESC	TCGA	PSTPPVS	DEG_SCF_FBW7_1	0.1389
p.A1082P	DO6332	CESC	ICGC	PSTPPVS	DEG_SCF_FBW7_1	0.1389
p.L1100I	TCGA-FS-A1ZR	SKCM	TCGA	PSTPPVS	DEG_SCF_FBW7_1	0.1944
p.L1100I	DO37651	SKCM	ICGC	PSTPPVS	DEG_SCF_FBW7_1	0.1944
p.S1098L	TCGA-LN-A8I1	ESCA	TCGA	PSTPPVS	DEG_SCF_FBW7_1	0.25
p.A1096D	DO228978	LICA	ICGC	PSTPPVS	DEG_SCF_FBW7_1	0.3056
p.T1084N	DO229028	LICA	ICGC	PSTPPVS	DEG_SCF_FBW7_1	0.1944
p.T1084N	DO229036	LICA	ICGC	PSTPPVS	DEG_SCF_FBW7_1	0.1944
p.F1103L	SIDM00545	Melanoma	GDSC	PSTPPVS	DEG_SCF_FBW7_1	0.1111
p.F1103L	Mewo	skin	COSMIC	PSTPPVS	DEG_SCF_FBW7_1	0.1111
p.T1079A	SIDM01716	Non-Cancerous	GDSC	PSTPPVS	DEG_SCF_FBW7_1	0.0556
p.T1079A	SIDM00175	Melanoma	GDSC	PSTPPVS	DEG_SCF_FBW7_1	0.0556
p.T1079A	SIDM01135	Pancreatic Carcinoma	GDSC	PSTPPVS	DEG_SCF_FBW7_1	0.0556
p.T1079A	PANC-10-05	pancreas	COSMIC	PSTPPVS	DEG_SCF_FBW7_1	0.0556
p.G1101C	ACH-000954	Endometrial/Uterine Cancer	CCLE	PSTPPVS	DEG_SCF_FBW7_1	0.1667

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q07890	Son of sevenless homolog 2	DEG_SCF_FBW7_1	1089:1095	PSTPPVS	FBXW7	0.9246	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons