DegronMD

Uniprot ID: Q9H329

Source protein: Band 4.1-like protein 4B

Source gene: EPB41L4B

Class: DEG_SPOP_SBC_1

Location: 477:481

E3 ligase: SPOP

DEGRON score: 0.9088

ASA_SCORE: 79.36

COIL: 0.9012

CONS_SCORE: 0.3017

DSS_SCORE: 0.4482

HELIX: 0.0706

FCONS_SCORE: 0.9763

RIG_SCORE: 0.6616

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S481L	TCGA-24-1565	OV	TCGA	VLSSS	DEG_SPOP_SBC_1	0.7667
p.S481L	DO31719	OV	ICGC	VLSSS	DEG_SPOP_SBC_1	0.7667
p.R483Q	TCGA-AP-A056	UCEC	TCGA	VLSSS	DEG_SPOP_SBC_1	0.2778
p.R483Q	DO43971	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2778
p.R483W	TCGA-DU-6392	LGG	TCGA	VLSSS	DEG_SPOP_SBC_1	0.2778
p.R483W	DO234257	ESAD	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2778
p.R483W	DO22237	LGG	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2778
p.P474H	TCGA-EE-A29Q	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	0.25
p.P474H	DO37866	SKCM	ICGC	VLSSS	DEG_SPOP_SBC_1	0.25
p.S478L	DO9386	COAD	ICGC	VLSSS	DEG_SPOP_SBC_1	0.7667
p.A482E	DO228948	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.3056
p.P467Q	DO229038	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.0556
p.S475F	DO222908	MELA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2778
p.R477S	DO232761	PBCA	ICGC	VLSSS	DEG_SPOP_SBC_1	0.7427
p.G486A	DO51738	STAD	ICGC	VLSSS	DEG_SPOP_SBC_1	0.1944
p.S483L	DO42472	UCEC	ICGC	VLSSS	DEG_SPOP_SBC_1	0.2778
p.S475Y	SIDM00281	Other Solid Cancers	GDSC	VLSSS	DEG_SPOP_SBC_1	0.2778
p.S475Y	ACH-002100	Skin Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	0.2778
p.S475Y	DJM-1	skin	COSMIC	VLSSS	DEG_SPOP_SBC_1	0.2778
p.S479R	ACH-001282	Bone Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	0.7427

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O00182	Galectin-9	DEG_SPOP_SBC_1	37:41	VLSSS	SPOP	0.6739	More...
O00268	Transcription initiation factor TFIID subunit 4	DEG_SPOP_SBC_1	697:701	VLSSS	SPOP	0.7112	More...
O75113	NEDD4-binding protein 1	DEG_SPOP_SBC_1	254:258	VLSSS	SPOP	0.9995	More...
P19484	Transcription factor EB	DEG_SPOP_SBC_1	130:134	VLSSS	SPOP	0.9904	More...
P25054	Adenomatous polyposis coli protein	DEG_SPOP_SBC_1	291:295	VLSSS	SPOP	0.9986	More...
P98175	RNA-binding protein 10	DEG_SPOP_SBC_1	325:329	VLSSS	SPOP	0.7807	More...
Q07890	Son of sevenless homolog 2	DEG_SPOP_SBC_1	1276:1280	VLSSS	SPOP	0.9839	More...
Q14671	Pumilio homolog 1	DEG_SPOP_SBC_1	225:229	VLSSS	SPOP	0.9888	More...
Q15149	Plectin	DEG_SPOP_SBC_1	978:982	VLSSS	SPOP	0.6246	More...
Q15572	TATA box-binding protein-associated factor RNA polymerase I subunit C	DEG_SPOP_SBC_1	854:858	VLSSS	SPOP	0.893	More...
Q6IAA8	Ragulator complex protein LAMTOR1	DEG_SPOP_SBC_1	94:98	VLSSS	SPOP	0.5049	More...
Q6UUV7	CREB-regulated transcription coactivator 3	DEG_SPOP_SBC_1	341:345	VLSSS	SPOP	0.9871	More...
Q86WP2	Vasculin	DEG_SPOP_SBC_1	377:381	VLSSS	SPOP	0.9365	More...
Q8NDX5	Polyhomeotic-like protein 3	DEG_SPOP_SBC_1	225:229	VLSSS	SPOP	0.993	More...
Q8TB72	Pumilio homolog 2	DEG_SPOP_SBC_1	98:102	VLSSS	SPOP	0.9847	More...
Q8TCU4	Alstrom syndrome protein 1	DEG_SPOP_SBC_1	570:574	VLSSS	SPOP	0.9598	More...
Q8WUI4	Histone deacetylase 7	DEG_SPOP_SBC_1	505:509	VLSSS	SPOP	0.9515	More...
Q96EB6	NAD-dependent protein deacetylase sirtuin-1	DEG_SPOP_SBC_1	665:669	VLSSS	SPOP	0.888	More...
Q96IT1	Zinc finger protein 496	DEG_SPOP_SBC_1	356:360	VLSSS	SPOP	0.6662	More...
Q96P47	Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3	DEG_SPOP_SBC_1	526:530	VLSSS	SPOP	0.911	More...
Q96QF0	Rab-3A-interacting protein	DEG_SPOP_SBC_1	259:263	VLSSS	SPOP	0.9939	More...
Q9H329	Band 4.1-like protein 4B	DEG_SPOP_SBC_1	477:481	VLSSS	SPOP	0.9088	More...
Q9H4A3	Serine/threonine-protein kinase WNK1	DEG_SPOP_SBC_1	1894:1898	VLSSS	SPOP	0.9125	More...
Q9NS91	E3 ubiquitin-protein ligase RAD18	DEG_SPOP_SBC_1	430:434	VLSSS	SPOP	0.99	More...
Q9P212	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1	DEG_SPOP_SBC_1	1175:1179	VLSSS	SPOP	0.9697	More...
Q9UKG1	DCC-interacting protein 13-alpha	DEG_SPOP_SBC_1	687:691	VLSSS	SPOP	0.9973	More...
Q9Y2X9	Zinc finger protein 281	DEG_SPOP_SBC_1	77:81	VLSSS	SPOP	0.9826	More...
A6NMB1	Sialic acid-binding Ig-like lectin 16	DEG_SPOP_SBC_1	277:281	VLSSS	SPOP	0.7762	More...
P17098	Zinc finger protein 8	DEG_SPOP_SBC_1	183:187	VLSSS	SPOP	0.9973	More...
Q3B8N2	Galectin-9B	DEG_SPOP_SBC_1	37:41	VLSSS	SPOP	0.6051	More...
Q8N442	Translation factor GUF1, mitochondrial	DEG_SPOP_SBC_1	437:441	VLSSS	SPOP	0.5017	More...
Q6ZVF9	G protein-regulated inducer of neurite outgrowth 3	DEG_SPOP_SBC_1	177:181	VLSSS	SPOP	0.8195	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VLSSS

Degron related mutations and impact score

Drug responses associated with EPB41L4B mutations

All proteins holding degron of VLSSS