PLEC
UniProt ID: Q15149
Entrez ID: 5339
Protein name: Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)
External links: UniprotKB HGNC RefSeq COSMIC
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FUNCTION: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regul...
FUNCTION: Interlinks intermediate filaments with microtubules and microfilaments and anchors intermediate filaments to desmosomes or hemidesmosomes. Could also bind muscle proteins such as actin to membrane complexes in muscle. May be involved not only in the filaments network, but also in the regulation of their dynamics. Structural component of muscle. Isoform 9 plays a major role in the maintenance of myofiber integrity. {ECO:0000269|PubMed:12482924, ECO:0000269|PubMed:21109228}.
GO - Biological processes (BP):
actin cytoskeleton reorganization [GO:0031532]; actomyosin contractile ring assembly actin filament organization [GO:2000689]; adherens junction organization [GO:0034332]; cardiac muscle cell development [GO:0055013]; cell morphogenesis [GO:0000902]; cellular protein localization [GO:0034613]; cellu...
actin cytoskeleton reorganization [GO:0031532]; actomyosin contractile ring assembly actin filament organization [GO:2000689]; adherens junction organization [GO:0034332]; cardiac muscle cell development [GO:0055013]; cell morphogenesis [GO:0000902]; cellular protein localization [GO:0034613]; cellular response to extracellular stimulus [GO:0031668]; cellular response to fluid shear stress [GO:0071498]; cellular response to hydrostatic pressure [GO:0071464]; cellular response to mechanical stimulus [GO:0071260]; establishment of skin barrier [GO:0061436]; fibroblast migration [GO:0010761]; gene expression [GO:0010467]; hemidesmosome assembly [GO:0031581]; intermediate filament cytoskeleton organization [GO:0045104]; intermediate filament organization [GO:0045109]; keratinocyte development [GO:0003334]; leukocyte migration involved in immune response [GO:0002522]; mitochondrion morphogenesis [GO:0070584]; multicellular organism growth [GO:0035264]; myoblast differentiation [GO:0045445]; negative regulation of protein kinase activity [GO:0006469]; nucleus organization [GO:0006997]; peripheral nervous system myelin maintenance [GO:0032287]; protein-containing complex organization [GO:0043933]; regulation of ATP citrate synthase activity [GO:2000983]; regulation of vascular permeability [GO:0043114]; respiratory electron transport chain [GO:0022904]; response to food [GO:0032094]; sarcomere organization [GO:0045214]; skeletal muscle fiber development [GO:0048741]; skeletal myofibril assembly [GO:0014866]; T cell chemotaxis [GO:0010818]; tight junction organization [GO:0120193]; transmission of nerve impulse [GO:0019226]; wound healing [GO:0042060]
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GO - Molecular function (MF):
actin binding [GO:0003779]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; structural ...
actin binding [GO:0003779]; ankyrin binding [GO:0030506]; cadherin binding [GO:0045296]; dystroglycan binding [GO:0002162]; protein self-association [GO:0043621]; RNA binding [GO:0003723]; structural constituent of cytoskeleton [GO:0005200]; structural constituent of muscle [GO:0008307]; structural molecule activity [GO:0005198]
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GO - Cellular component (CC):
axon [GO:0030424]; brush border [GO:0005903]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:001602...
axon [GO:0030424]; brush border [GO:0005903]; costamere [GO:0043034]; cytoplasm [GO:0005737]; cytosol [GO:0005829]; dendrite [GO:0030425]; extracellular exosome [GO:0070062]; focal adhesion [GO:0005925]; hemidesmosome [GO:0030056]; intermediate filament cytoskeleton [GO:0045111]; membrane [GO:0016020]; mitochondrial outer membrane [GO:0005741]; myelin sheath [GO:0043209]; perinuclear region of cytoplasm [GO:0048471]; plasma membrane [GO:0005886]; sarcolemma [GO:0042383]; sarcoplasm [GO:0016528]; Z disc [GO:0030018]
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PLEC
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Kaplan plot for PLEC in
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*NOTE: the Kaplan plots were collected from OncoLnc