DegronMD - Q15149(PLEC)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.P4461H	TCGA-18-3409	LUSC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6583
p.D4219N	TCGA-24-2288	OV	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.D4219N	SIDM01448	Head and Neck Carcinoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.D4219N	ACH-000500	Head and Neck Cancer	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.A110T	TCGA-34-7107	LUSC	TCGA	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.6028
p.A110T	DO26449	LUSC	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.6028
p.G3324R	TCGA-34-8454	LUSC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.7568
p.R4466L	TCGA-55-7907	LUAD	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.3056
p.R99C	TCGA-68-8251	LUSC	TCGA	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.25
p.R99C	TCGA-A5-A2K3	UCEC	TCGA	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.25
p.R99C	DO26858	LUSC	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.25
p.R99C	DO43899	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.25
p.E4465D	TCGA-77-A5GB	LUSC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6758
p.E4465K	TCGA-77-A5GB	LUSC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.7022
p.R4401S	TCGA-77-A5GB	LUSC	TCGA	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.0556
p.D4460N	TCGA-91-6836	LUAD	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.5821
p.D4460N	SIDM00400	B-Cell Non-Hodgkin's Lymphoma	GDSC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.5821
p.D4460N	SIDM00534	Colorectal Carcinoma	GDSC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.5821
p.D4460N	ACH-000986	Colon/Colorectal Cancer	CCLE	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.5821
p.D4460N	ACH-002392	Lymphoma	CCLE	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.5821
p.D4460N	HT-115	large intestine	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.5821
p.D4460N	SC-1	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.5821
p.R4206H	TCGA-A5-A0G2	UCEC	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7133
p.R4206H	TCGA-BR-8363	STAD	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7133
p.R4206H	SIDM01050	Biliary Tract Carcinoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7133
p.R4206H	ACH-001494	Bile Duct Cancer	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7133
p.R4206H	EGI-1	biliary tract	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7133
p.R112H	TCGA-B5-A0JY	UCEC	TCGA	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.2778
p.R112H	DO43041	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.2778
p.P4199T	TCGA-BR-6458	STAD	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1667
p.A4472T	TCGA-BR-8284	STAD	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1389
p.A4472T	TCGA-EO-A22R	UCEC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1389
p.A4472T	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1389
p.R4197W	TCGA-BR-8363	STAD	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.R4197W	SIDM00844	Burkitt's Lymphoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.R4197W	ACH-000654	Lymphoma	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.R4197W	Raji	haematopoietic and lymphoid tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.R4381H	TCGA-BR-8368	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1667
p.R4381H	TCGA-CV-A6K1	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1667
p.R4381H	TCGA-EI-6917	READ	TCGA	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1667
p.R4381H	SIDM00621	Ewing's Sarcoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1667
p.R4381H	ACH-002113	Bone Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1667
p.R4381H	EW-13	bone	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1667
p.S4221L	TCGA-BR-A4QL	STAD	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.0556
p.A4398T	TCGA-CD-A4MI	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.A4398T	TCGA-FI-A2D5	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.A4398T	SIDM00375	Head and Neck Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.A4398T	SIDM00118	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.A4398T	ACH-001081	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.A4398T	ACH-002305	Head and Neck Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.A4398T	HCC2998	large intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.A4398T	SKN-3	upper aerodigestive tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.S4389F	TCGA-D3-A5GS	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.9093
p.V988M	TCGA-DU-6392	LGG	TCGA	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1667
p.V116M	TCGA-E6-A1LX	UCEC	TCGA	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1667
p.V116M	DO41020	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1667
p.S4391F	TCGA-EB-A3XD	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.9093
p.S990F	TCGA-EB-A431	SKCM	TCGA	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1111
p.L97V	TCGA-EK-A3GK	CESC	TCGA	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1944
p.L97V	DO49964	CESC	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1944
p.D3314G	TCGA-EO-A22R	UCEC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1667
p.A486V	TCGA-F4-6570	COAD	TCGA	PPGY	ITCH	495:498	Mutation rewiring degron network	0.0833
p.P150H	TCGA-F4-6570	COAD	TCGA	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.3056
p.P150H	DO10443	COAD	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.3056
p.E4212Q	TCGA-FD-A5BX	BLCA	TCGA	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.3056
p.K505N	TCGA-HJ-7597	STAD	TCGA	PPGY	ITCH	495:498	Mutation substituting flanking lysine	0.25
p.V4473I	TCGA-HU-8602	STAD	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1111
p.E4465G	TCGA-LA-A446	LUSC	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.7199
p.L492F	TCGA-VQ-AA6I	STAD	TCGA	PPGY	ITCH	495:498	Mutation rewiring degron network	0.25
p.A4472V	TCGA-W3-A828	SKCM	TCGA	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1389
p.S4205L	DO51882	BLCA	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7667
p.S4205L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7667
p.E968K	DO219099	BLCA	ICGC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.0556
p.R147Q	DO219078	BLCA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7329
p.R147Q	DO220890	MELA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7329
p.R147Q	PCI-6A	upper aerodigestive tract	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7329
p.S4196F	DO514	BLCA	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.0833
p.T134M	DO222427	BTCA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.T134M	DO228475	MALY	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.R4470H	DO222427	BTCA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1944
p.A3326V	DO222427	BTCA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.3056
p.E146Q	DO222834	BTCA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.5633
p.G96D	DO223703	COAD	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1667
p.R4382C	DO9698	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.6389
p.S3310L	DO230336	COCA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.0556
p.R4394C	DO224812	COCA	ICGC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.25
p.G4206D	DO222884	COCA	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7198
p.T3317M	DO229016	COCA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.25
p.R156K	DO219921	DLBC	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1389
p.E502K	DO222500	ESCA	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.2222
p.V148M	DO233109	GACA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6097
p.R4388H	DO233259	GACA	ICGC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.8244
p.R4388H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.8244
p.P978L	DO233283	GACA	ICGC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation altering degron motif	0.7582
p.G4460S	DO233767	GACA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6993
p.L102H	DO233821	GACA	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.7313
p.A3326T	DO13522	GBM	ICGC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.3056
p.A4379T	DO44411	GBM	ICGC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.D487N	DO44440	HNSC	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.1111
p.R4382H	DO14159	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.6389
p.R4382H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.6389
p.R4212H	DO52078	HNSC	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.3056
p.R4212H	DO36881	READ	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.3056
p.R4212H	DO47981	STAD	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.3056
p.R4212H	EW-13	bone	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.3056
p.A4467V	DO52070	HNSC	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.2778
p.A4379G	DO49669	LIAD	ICGC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.R970L	DO228380	LICA	ICGC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1111
p.R138W	DO228552	LICA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.25
p.A105D	DO228974	LICA	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.7793
p.R4471S	DO228976	LICA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1667
p.R506S	DO229025	LICA	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.1111
p.R506S	DO37782	SKCM	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.1111
p.T3317K	DO229027	LICA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.25
p.A157T	DO48703	LIRI	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.G4452C	DO23732	LUAD	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1111
p.S4451F	DO45390	LUAD	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.0833
p.V4396L	DO23923	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.6389
p.L110V	DO45323	LUAD	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.6765
p.D980N	DO230525	LUSC	ICGC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation altering degron motif	0.6932
p.I4197V	DO219176	LUSC	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.P103L	DO220906	MELA	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.7582
p.P983S	DO222395	MELA	ICGC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.3056
p.S136L	DO222638	MELA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1944
p.R974C	DO231997	ORCA	ICGC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.2222
p.Q504P	DO46657	PAAD	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.1667
p.A105T	DO228138	PBCA	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.7139
p.R159H	DO232224	PBCA	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.5
p.S4451Y	DO232224	PBCA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.0833
p.S4469P	DO219881	SKCA	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.2222
p.Q144K	DO37715	SKCM	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6944
p.Q144K	DO37444	SKCM	ICGC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6944
p.S4220F	DO47706	SKCM	ICGC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.0833
p.V119L	DO37966	SKCM	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.0833
p.T4463I	DO51282	SKCM	ICGC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.7078
p.V3315M	DO38823	STAD	ICGC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1944
p.V3315M	BHY	upper aerodigestive tract	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1944
p.V3315M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1944
p.A4390T	DO47981	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.7139
p.A4390T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.7139
p.T969M	DO229224	THCA	ICGC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.0833
p.R491C	DO219784	UCEC	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.2222
p.R491H	DO48174	UCEC	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.2222
p.R506C	DO43250	UCEC	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.1111
p.A94T	DO41650	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1111
p.E502D	DO41903	UCEC	ICGC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.2222
p.H111R	DO41331	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.3056
p.P94S	SIDM02041	Colorectal Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1111
p.V104I	SIDM01943	Colorectal Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.5965
p.L4208I	SIDM02013	Colorectal Carcinoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.6063
p.V4399I	SIDM00582	Pancreatic Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM00932	Kidney Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM00299	Other Sarcomas	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM00907	Burkitt's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM00618	Hepatocellular Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM00045	Gastric Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM01770	Gastric Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM01622	Breast Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.V4399I	SIDM01471	Chronic Myelogenous Leukemia	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.R102H	SIDM01037	Breast Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.7133
p.R3335W	SIDM00946	T-Lymphoblastic Leukemia	GDSC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.0556
p.R3335W	SIDM00169	Head and Neck Carcinoma	GDSC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.0556
p.R3335W	ACH-000692	Head and Neck Cancer	CCLE	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.0556
p.R3335W	ACH-000981	Leukemia	CCLE	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.0556
p.G4207S	SIDM00545	Melanoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.5882
p.G4207S	SIDM00127	Oral Cavity Carcinoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.5882
p.G4207S	JHU-022	upper aerodigestive tract	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.5882
p.G4207S	Mewo	skin	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.5882
p.P4468L	SIDM00680	Colorectal Carcinoma	GDSC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.25
p.P114A	SIDM01126	Small Cell Lung Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.2222
p.S984R	SIDM00318	Kidney Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.2778
p.S984R	ACH-000484	Kidney Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.2778
p.R4466H	SIDM00449	B-Lymphoblastic Leukemia	GDSC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.3056
p.R4466H	ACH-000922	Leukemia	CCLE	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.3056
p.R4466H	RCH-ACV	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.3056
p.H499Q	SIDM01114	Non-Cancerous	GDSC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.3056
p.H499Q	ACH-001383	Prostate Cancer	CCLE	PPGY	ITCH	495:498	Mutation rewiring degron network	0.3056
p.H499Q	PWR-1E	prostate	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.3056
p.G4464S	SIDM00934	Pancreatic Carcinoma	GDSC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6993
p.G4464S	SIDM00306	Non-Small Cell Lung Carcinoma	GDSC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6993
p.G4464S	ACH-000354	Pancreatic Cancer	CCLE	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6993
p.G4464S	ACH-000672	Lung Cancer	CCLE	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6993
p.G4464S	CAPAN-1	pancreas	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6993
p.G4464S	IA-LM	lung	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.6993
p.P4220L	SIDM00177	Melanoma	GDSC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.0833
p.P4220L	ACH-002338	Skin Cancer	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.0833
p.P4220L	ACH-002510	Skin Cancer	CCLE	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.0833
p.S982F	SIDM00221	Melanoma	GDSC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation altering degron motif	0.7982
p.G983S	SIDM00892	Breast Carcinoma	GDSC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.3056
p.A4377T	SIDM00539	Esophageal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.0556
p.A4377T	SIDM00783	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.0556
p.W507R	SIDM00451	T-Lymphoblastic Leukemia	GDSC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.0833
p.R102L	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.7316
p.V100M	SIDM01617	Endometrial Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.2778
p.V100M	ACH-000994	Endometrial/Uterine Cancer	CCLE	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.2778
p.R4381C	SIDM00158	Glioblastoma	GDSC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1667
p.P3321S	SIDM01726	Ewing's Sarcoma	GDSC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.5641
p.P3321S	ACH-000119	Non-Cancerous	CCLE	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.5641
p.V154E	ACH-000616	Gastric Cancer	CCLE	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1944
p.H115D	ACH-000720	Bladder Cancer	CCLE	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1944
p.E144K	ACH-000763	Myeloma	CCLE	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.591
p.R141P	ACH-000870	Lung Cancer	CCLE	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.6401
p.Y4393S	ACH-001126	Brain Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.7222
p.E985K	ACH-001393	Breast Cancer	CCLE	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.25
p.A4453T	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1389
p.R496G	22RV1	prostate	COSMIC	PPGY	ITCH	495:498	Mutation altering degron motif	0.7568
p.A4400T	CML-T1	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.5278
p.I4205V	KYSE-70	oesophagus	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7076
p.P4393R	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.7222
p.E3323Q	PL4	pancreas	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.6744
p.R500G	22RV1	prostate	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.2778
p.S4459N	OCUB-M	breast	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.3056
p.G3323V	HMV-II	skin	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.7532
p.D4196G	ECC10	stomach	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.0833
p.Q977L	MZ2-MEL	skin	COSMIC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.3056
p.V3325M	BHY	upper aerodigestive tract	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.7208
p.T4393I	BE-13	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.7222
p.T4393I	NCI-H2291	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.7222
p.S4209L	SNU-C5	large intestine	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7667
p.I4209V	KYSE-70	oesophagus	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7076
p.L3330P	NB1	autonomic ganglia	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1944
p.R988H	SW1990	pancreas	COSMIC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1667
p.T4389I	NCI-H2291	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.7078
p.T4389I	BE-13	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.7078
p.G4204V	NCI-H2342	lung	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.3056
p.R4390H	NCI-H1155	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.8244
p.P3311L	CP67-MEL	skin	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.0833
p.E3335V	LNCaP-Clone-FGC	prostate	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.0556
p.G3321A	AsPC-1	pancreas	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.754
p.I105V	MFE-319	endometrium	COSMIC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.7076
p.T4384M	VCaP	prostate	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.6944
p.G3321W	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.7825
p.I137V	MFE-319	endometrium	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2222
p.P4389Q	SKN-3	upper aerodigestive tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.7035
p.D4379N	TT2609-C02	thyroid	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1111
p.E4396G	CCK-81	large intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.6389
p.S4467N	OCUB-M	breast	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.2778
p.P3315L	CP67-MEL	skin	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1944
p.V3319M	NALM-6	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.3056
p.L507P	H-EMC-SS	bone	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.0833
p.L507P	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.0833
p.E4378G	CCK-81	large intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.0833
p.D109V	OVMIU	ovary	COSMIC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.7785
p.V4458I	JHU-011	upper aerodigestive tract	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.2778
p.R984H	SW1990	pancreas	COSMIC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.2778
p.P3334L	CP67-MEL	skin	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.0833
p.R492C	LIM1215	large intestine	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.25
p.R500C	LIM1215	large intestine	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.2778
p.A3319S	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.3056
p.A4201T	AN3-CA	endometrium	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.2222
p.R970H	SW1990	pancreas	COSMIC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation rewiring degron network	0.1111
p.V4466I	JHU-011	upper aerodigestive tract	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.3056
p.D150V	OVMIU	ovary	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.3056
p.T4394M	VCaP	prostate	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.25
p.I115V	MFE-319	endometrium	COSMIC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1944
p.G3327S	DND-41	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.2778
p.R4452L	DU-145	prostate	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.1111
p.L506P	LNCaP-Clone-FGC	prostate	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.1111
p.Q981L	MZ2-MEL	skin	COSMIC	VLSSS	DEG_SPOP_SBC_1	978:982	Mutation altering degron motif	0.7765
p.V3333M	BHY	upper aerodigestive tract	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1111
p.G4200V	NCI-H2342	lung	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1944
p.V145M	SW620	large intestine	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7208
p.R4198H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1389
p.P4381Q	SKN-3	upper aerodigestive tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1667
p.D4387N	TT2609-C02	thyroid	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.6932
p.S4213L	SNU-C5	large intestine	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.2778
p.L497P	H-EMC-SS	bone	COSMIC	PPGY	ITCH	495:498	Mutation altering degron motif	0.7582
p.L497P	NOMO-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	495:498	Mutation altering degron motif	0.7582
p.R4466W	23132-87	stomach	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.3056
p.R4456L	DU-145	prostate	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation rewiring degron network	0.2222
p.D4200G	ECC10	stomach	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1944
p.R4392H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.75
p.G3325W	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.7825
p.S4215L	NALM-6	haematopoietic and lymphoid tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.2222
p.V496M	BALL-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	495:498	Mutation altering degron motif	0.7208
p.L496P	LNCaP-Clone-FGC	prostate	COSMIC	PPGY	ITCH	495:498	Mutation altering degron motif	0.7582
p.R157Q	PCI-6A	upper aerodigestive tract	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1111
p.R499C	DJM-1	skin	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.3056
p.I141V	MFE-319	endometrium	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7076
p.G3331V	HMV-II	skin	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1667
p.V118M	SW620	large intestine	COSMIC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1111
p.A4211T	AN3-CA	endometrium	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation altering degron motif	0.7139
p.V500M	BALL-1	haematopoietic and lymphoid tissue	COSMIC	PPGY	ITCH	495:498	Mutation rewiring degron network	0.2778
p.Y143C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation altering degron motif	0.7087
p.E4388G	CCK-81	large intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation altering degron motif	0.7199
p.D4219G	ECC10	stomach	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.R4386H	NCI-H1155	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.75
p.T3314A	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1667
p.P4385R	KMS-12-BM	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.7222
p.R495C	DJM-1	skin	COSMIC	PPGY	ITCH	495:498	Mutation altering degron motif	0.8301
p.V104M	SW620	large intestine	COSMIC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation altering degron motif	0.6097
p.G3325A	AsPC-1	pancreas	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.754
p.A4219T	AN3-CA	endometrium	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.1111
p.A3323S	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.7588
p.Y153C	KARPAS-45	haematopoietic and lymphoid tissue	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.2222
p.R4202H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.25
p.R4398H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.1389
p.R4221H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	KRGLFDE	LIG_APCC_ABBAyCdc20_2	4205:4211	Mutation rewiring degron network	0.0556
p.T3322A	KCL-22	haematopoietic and lymphoid tissue	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation altering degron motif	0.7139
p.R4475L	DU-145	prostate	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation substituting flanking lysine	0.1667
p.S154T	BHT-101	thyroid	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation rewiring degron network	0.1944
p.G3313V	HMV-II	skin	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.1389
p.E3319Q	PL4	pancreas	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	3320:3325	Mutation rewiring degron network	0.3056
p.T152P	OV-56	ovary	COSMIC	RRKELEEVS	DEG_APCC_DBOX_1	141:149	Mutation blocking phosphorylation signal	0.6944
p.D4401N	TT2609-C02	thyroid	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation rewiring degron network	0.0556
p.R4400H	MOLT-16	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	4387:4391	Mutation blocking phosphorylation signal	0.5278
p.D101V	OVMIU	ovary	COSMIC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.3056
p.R4462W	23132-87	stomach	COSMIC	DPSTGE	DEG_Kelch_Keap1_1	4460:4465	Mutation altering degron motif	0.8634
p.V96M	SW620	large intestine	COSMIC	RPVAMVMPA	DEG_SIAH_1	102:110	Mutation rewiring degron network	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PLEC

UniProt ID: Q15149

Entrez ID: 5339

Protein name: Plectin (PCN) (PLTN) (Hemidesmosomal protein 1) (HD1) (Plectin-1)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PLEC in