DegronMD

Uniprot ID: Q15149

Source protein: Plectin

Source gene: PLEC

Class: DEG_SIAH_1

Location: 102:110

E3 ligase: SIAH1,SIAH2,SIAH3

DEGRON score: 0.7178

ASA_SCORE: 87.1889

COIL: 0.7377

CONS_SCORE: 0.4783

DSS_SCORE: 0.4308

HELIX: 0.1994

FCONS_SCORE: 0.9048

RIG_SCORE: 0.738

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.A110T	TCGA-34-7107	LUSC	TCGA	RPVAMVMPA	DEG_SIAH_1	0.6028
p.A110T	DO26449	LUSC	ICGC	RPVAMVMPA	DEG_SIAH_1	0.6028
p.R99C	TCGA-68-8251	LUSC	TCGA	RPVAMVMPA	DEG_SIAH_1	0.25
p.R99C	TCGA-A5-A2K3	UCEC	TCGA	RPVAMVMPA	DEG_SIAH_1	0.25
p.R99C	DO26858	LUSC	ICGC	RPVAMVMPA	DEG_SIAH_1	0.25
p.R99C	DO43899	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	0.25
p.R112H	TCGA-B5-A0JY	UCEC	TCGA	RPVAMVMPA	DEG_SIAH_1	0.2778
p.R112H	DO43041	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	0.2778
p.V116M	TCGA-E6-A1LX	UCEC	TCGA	RPVAMVMPA	DEG_SIAH_1	0.1667
p.V116M	DO41020	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	0.1667
p.L97V	TCGA-EK-A3GK	CESC	TCGA	RPVAMVMPA	DEG_SIAH_1	0.1944
p.L97V	DO49964	CESC	ICGC	RPVAMVMPA	DEG_SIAH_1	0.1944
p.G96D	DO223703	COAD	ICGC	RPVAMVMPA	DEG_SIAH_1	0.1667
p.L102H	DO233821	GACA	ICGC	RPVAMVMPA	DEG_SIAH_1	0.7313
p.A105D	DO228974	LICA	ICGC	RPVAMVMPA	DEG_SIAH_1	0.7793
p.L110V	DO45323	LUAD	ICGC	RPVAMVMPA	DEG_SIAH_1	0.6765
p.P103L	DO220906	MELA	ICGC	RPVAMVMPA	DEG_SIAH_1	0.7582
p.A105T	DO228138	PBCA	ICGC	RPVAMVMPA	DEG_SIAH_1	0.7139
p.V119L	DO37966	SKCM	ICGC	RPVAMVMPA	DEG_SIAH_1	0.0833
p.A94T	DO41650	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	0.1111
p.H111R	DO41331	UCEC	ICGC	RPVAMVMPA	DEG_SIAH_1	0.3056
p.P94S	SIDM02041	Colorectal Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	0.1111
p.V104I	SIDM01943	Colorectal Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	0.5965
p.R102H	SIDM01037	Breast Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	0.7133
p.P114A	SIDM01126	Small Cell Lung Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	0.2222
p.R102L	SIDM01667	B-Cell Non-Hodgkin's Lymphoma	GDSC	RPVAMVMPA	DEG_SIAH_1	0.7316
p.V100M	SIDM01617	Endometrial Carcinoma	GDSC	RPVAMVMPA	DEG_SIAH_1	0.2778
p.V100M	ACH-000994	Endometrial/Uterine Cancer	CCLE	RPVAMVMPA	DEG_SIAH_1	0.2778
p.H115D	ACH-000720	Bladder Cancer	CCLE	RPVAMVMPA	DEG_SIAH_1	0.1944
p.I105V	MFE-319	endometrium	COSMIC	RPVAMVMPA	DEG_SIAH_1	0.7076
p.D109V	OVMIU	ovary	COSMIC	RPVAMVMPA	DEG_SIAH_1	0.7785
p.I115V	MFE-319	endometrium	COSMIC	RPVAMVMPA	DEG_SIAH_1	0.1944
p.V118M	SW620	large_intestine	COSMIC	RPVAMVMPA	DEG_SIAH_1	0.1111
p.V104M	SW620	large_intestine	COSMIC	RPVAMVMPA	DEG_SIAH_1	0.6097
p.D101V	OVMIU	ovary	COSMIC	RPVAMVMPA	DEG_SIAH_1	0.3056
p.V96M	SW620	large_intestine	COSMIC	RPVAMVMPA	DEG_SIAH_1	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: RPVAMVMPA

Degron related mutations and impact score

Drug responses associated with PLEC mutations

All proteins holding degron of RPVAMVMPA

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q15149	Plectin	DEG_SIAH_1	102:110	RPVAMVMPA	SIAH1,SIAH2,SIAH3	0.7178	More...