DegronMD

Uniprot ID: Q15149

Source protein: Plectin

Source gene: PLEC

Class: DEG_SPOP_SBC_1

Location: 4387:4391

E3 ligase: SPOP

DEGRON score: 0.9829

ASA_SCORE: 64.54

COIL: 0.746

CONS_SCORE: 0.6142

DSS_SCORE: 0.4256

HELIX: 0.0722

FCONS_SCORE: 0.9283

RIG_SCORE: 0.5567

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R4401S	TCGA-77-A5GB	LUSC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.0556
p.R4381H	TCGA-BR-8368	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1667
p.R4381H	TCGA-CV-A6K1	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1667
p.R4381H	TCGA-EI-6917	READ	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1667
p.R4381H	SIDM00621	Ewing's Sarcoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.R4381H	ACH-002113	Bone Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.1667
p.R4381H	EW-13	bone	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.A4398T	TCGA-CD-A4MI	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A4398T	TCGA-FI-A2D5	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A4398T	SIDM00375	Head and Neck Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A4398T	SIDM00118	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A4398T	ACH-001081	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A4398T	ACH-002305	Head and Neck Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A4398T	HCC2998	large_intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A4398T	SKN-3	upper_aerodigestive_tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.S4389F	TCGA-D3-A5GS	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.9093
p.S4391F	TCGA-EB-A3XD	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.9093
p.R4382C	DO9698	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	0.6389
p.R4394C	DO224812	COCA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.25
p.R4388H	DO233259	GACA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.8244
p.R4388H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.8244
p.A4379T	DO44411	GBM	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.R4382H	DO14159	HNSC	ICGC	VGSSS	DEG_SPOP_SBC_1	0.6389
p.R4382H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.6389
p.A4379G	DO49669	LIAD	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4396L	DO23923	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	0.6389
p.A4390T	DO47981	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	0.7139
p.A4390T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7139
p.V4399I	SIDM00582	Pancreatic Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM01038	B-Cell Non-Hodgkin's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM00932	Kidney Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM00548	Squamous Cell Lung Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM00299	Other Sarcomas	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM00907	Burkitt's Lymphoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM00618	Hepatocellular Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM00045	Gastric Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM01770	Gastric Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM01622	Breast Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.V4399I	SIDM01471	Chronic Myelogenous Leukemia	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.A4377T	SIDM00539	Esophageal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.0556
p.A4377T	SIDM00783	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.0556
p.R4381C	SIDM00158	Glioblastoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.Y4393S	ACH-001126	Brain Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.7222
p.A4400T	CML-T1	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.5278
p.P4393R	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7222
p.T4393I	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7222
p.T4393I	NCI-H2291	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7222
p.T4389I	NCI-H2291	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7078
p.T4389I	BE-13	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7078
p.R4390H	NCI-H1155	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.8244
p.T4384M	VCaP	prostate	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.6944
p.P4389Q	SKN-3	upper_aerodigestive_tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7035
p.D4379N	TT2609-C02	thyroid	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.E4396G	CCK-81	large_intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.6389
p.E4378G	CCK-81	large_intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.0833
p.T4394M	VCaP	prostate	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.25
p.P4381Q	SKN-3	upper_aerodigestive_tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.D4387N	TT2609-C02	thyroid	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.6932
p.R4392H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.75
p.E4388G	CCK-81	large_intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7199
p.R4386H	NCI-H1155	lung	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.75
p.P4385R	KMS-12-BM	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.7222
p.R4398H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.D4401N	TT2609-C02	thyroid	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.0556
p.R4400H	MOLT-16	haematopoietic_and_lymphoid_tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.5278

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94972	E3 ubiquitin-protein ligase TRIM37	DEG_SPOP_SBC_1	591:595	VGSSS	SPOP	0.7449	More...
P25025	C-X-C chemokine receptor type 2	DEG_SPOP_SBC_1	349:353	VGSSS	SPOP	0.8617	More...
Q05469	Hormone-sensitive lipase	DEG_SPOP_SBC_1	238:242	VGSSS	SPOP	0.9766	More...
Q15149	Plectin	DEG_SPOP_SBC_1	4387:4391	VGSSS	SPOP	0.9829	More...
Q5SXH7	Pleckstrin homology domain-containing family S member 1	DEG_SPOP_SBC_1	166:170	VGSSS	SPOP	0.9981	More...
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_SPOP_SBC_1	1208:1212	VGSSS	SPOP	0.9095	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	2777:2781	VGSSS	SPOP	0.6097	More...
Q6GQQ9	OTU domain-containing protein 7B	DEG_SPOP_SBC_1	472:476	VGSSS	SPOP	0.9978	More...
Q6IMN6	Caprin-2	DEG_SPOP_SBC_1	603:607	VGSSS	SPOP	0.9899	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1871:1875	VGSSS	SPOP	0.9665	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	297:301	VGSSS	SPOP	0.9039	More...
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_SPOP_SBC_1	851:855	VGSSS	SPOP	0.9618	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	333:337	VGSSS	SPOP	0.9838	More...
Q99590	Protein SCAF11	DEG_SPOP_SBC_1	470:474	VGSSS	SPOP	0.9942	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	134:138	VGSSS	SPOP	0.9842	More...
Q9H5N1	Rab GTPase-binding effector protein 2	DEG_SPOP_SBC_1	243:247	VGSSS	SPOP	0.9275	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	754:758	VGSSS	SPOP	0.9976	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	517:521	VGSSS	SPOP	0.9803	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	295:299	VGSSS	SPOP	0.9306	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1440:1444	VGSSS	SPOP	0.9873	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	DEG_SPOP_SBC_1	541:545	VGSSS	SPOP	0.9539	More...
Q9UQR1	Zinc finger protein 148	DEG_SPOP_SBC_1	587:591	VGSSS	SPOP	0.95	More...
Q9Y6H8	Gap junction alpha-3 protein	DEG_SPOP_SBC_1	355:359	VGSSS	SPOP	0.9829	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	1533:1537	VGSSS	SPOP	0.9666	More...
A6NEL2	Ankyrin repeat domain-containing protein SOWAHB	DEG_SPOP_SBC_1	738:742	VGSSS	SPOP	0.9911	More...
Q14582	Max dimerization protein 4	DEG_SPOP_SBC_1	174:178	VGSSS	SPOP	0.9872	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1545:1549	VGSSS	SPOP	0.8639	More...
Q8N5Q1	Golgi associated RAB2 interactor protein 5B	DEG_SPOP_SBC_1	869:873	VGSSS	SPOP	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGSSS

Degron related mutations and impact score

Drug responses associated with PLEC mutations

All proteins holding degron of VGSSS