DegronMD

Uniprot ID: O94972

Source protein: E3 ubiquitin-protein ligase TRIM37

Source gene: TRIM37

Class: DEG_SPOP_SBC_1

Location: 591:595

E3 ligase: SPOP

DEGRON score: 0.7449

ASA_SCORE: 58.56

COIL: 0.7198

CONS_SCORE: 0.2723

DSS_SCORE: 0.422

HELIX: 0.148

FCONS_SCORE: 1.0118

RIG_SCORE: 0.6357

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R599T	TCGA-18-3406	LUSC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.2222
p.S587C	TCGA-AD-6895	COAD	TCGA	VGSSS	DEG_SPOP_SBC_1	0.2222
p.S587C	DO8938	COAD	ICGC	VGSSS	DEG_SPOP_SBC_1	0.2222
p.T601A	TCGA-AX-A06H	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1667
p.T601A	DO43530	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.S587N	TCGA-B5-A0JY	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.2222
p.S587N	SIDM00789	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.2222
p.S587N	ACH-000997	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.2222
p.S587N	ACH-001061	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.2222
p.S587N	ACH-001091	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.2222
p.S587N	HCT-15	large_intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.2222
p.A584S	TCGA-CX-7219	HNSC	TCGA	VGSSS	DEG_SPOP_SBC_1	0.1389
p.S593F	TCGA-FR-A729	SKCM	TCGA	VGSSS	DEG_SPOP_SBC_1	0.7982
p.A584V	DO227646	COCA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.P605H	DO229019	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.0556
p.P583T	DO229032	LICA	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.L600V	DO43306	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	0.1944
p.G585S	SIDM00301	Pancreatic Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.G585S	SIDM01608	Endometrial Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.G585S	KP-4	pancreas	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.1667
p.P583H	SIDM00694	Other Solid Cancers	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1111
p.G592R	SIDM00489	Oral Cavity Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.6457
p.G592R	ACH-002043	Head and Neck Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.6457
p.G592R	Ca9-22	upper_aerodigestive_tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.6457
p.A584T	SIDM00217	Colorectal Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A584T	ACH-000999	Colon/Colorectal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	0.1389
p.A584T	SNU-1040	large_intestine	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.1389
p.R594W	FU97	stomach	COSMIC	VGSSS	DEG_SPOP_SBC_1	0.8634

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
O94972	E3 ubiquitin-protein ligase TRIM37	DEG_SPOP_SBC_1	591:595	VGSSS	SPOP	0.7449	More...
P25025	C-X-C chemokine receptor type 2	DEG_SPOP_SBC_1	349:353	VGSSS	SPOP	0.8617	More...
Q05469	Hormone-sensitive lipase	DEG_SPOP_SBC_1	238:242	VGSSS	SPOP	0.9766	More...
Q15149	Plectin	DEG_SPOP_SBC_1	4387:4391	VGSSS	SPOP	0.9829	More...
Q5SXH7	Pleckstrin homology domain-containing family S member 1	DEG_SPOP_SBC_1	166:170	VGSSS	SPOP	0.9981	More...
Q5T5Y3	Calmodulin-regulated spectrin-associated protein 1	DEG_SPOP_SBC_1	1208:1212	VGSSS	SPOP	0.9095	More...
Q5VST9	Obscurin	DEG_SPOP_SBC_1	2777:2781	VGSSS	SPOP	0.6097	More...
Q6GQQ9	OTU domain-containing protein 7B	DEG_SPOP_SBC_1	472:476	VGSSS	SPOP	0.9978	More...
Q6IMN6	Caprin-2	DEG_SPOP_SBC_1	603:607	VGSSS	SPOP	0.9899	More...
Q8IWI9	MAX gene-associated protein	DEG_SPOP_SBC_1	1871:1875	VGSSS	SPOP	0.9665	More...
Q8NDV7	Trinucleotide repeat-containing gene 6A protein	DEG_SPOP_SBC_1	297:301	VGSSS	SPOP	0.9039	More...
Q92953	Potassium voltage-gated channel subfamily B member 2	DEG_SPOP_SBC_1	851:855	VGSSS	SPOP	0.9618	More...
Q99569	Plakophilin-4	DEG_SPOP_SBC_1	333:337	VGSSS	SPOP	0.9838	More...
Q99590	Protein SCAF11	DEG_SPOP_SBC_1	470:474	VGSSS	SPOP	0.9942	More...
Q9BSE4	Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 2 protein	DEG_SPOP_SBC_1	134:138	VGSSS	SPOP	0.9842	More...
Q9H5N1	Rab GTPase-binding effector protein 2	DEG_SPOP_SBC_1	243:247	VGSSS	SPOP	0.9275	More...
Q9H792	Inactive tyrosine-protein kinase PEAK1	DEG_SPOP_SBC_1	754:758	VGSSS	SPOP	0.9976	More...
Q9HAK2	Transcription factor COE2	DEG_SPOP_SBC_1	517:521	VGSSS	SPOP	0.9803	More...
Q9UHD9	Ubiquilin-2	DEG_SPOP_SBC_1	295:299	VGSSS	SPOP	0.9306	More...
Q9ULT8	E3 ubiquitin-protein ligase HECTD1	DEG_SPOP_SBC_1	1440:1444	VGSSS	SPOP	0.9873	More...
Q9UPZ9	Serine/threonine-protein kinase ICK	DEG_SPOP_SBC_1	541:545	VGSSS	SPOP	0.9539	More...
Q9UQR1	Zinc finger protein 148	DEG_SPOP_SBC_1	587:591	VGSSS	SPOP	0.95	More...
Q9Y6H8	Gap junction alpha-3 protein	DEG_SPOP_SBC_1	355:359	VGSSS	SPOP	0.9829	More...
Q9Y6V0	Protein piccolo	DEG_SPOP_SBC_1	1533:1537	VGSSS	SPOP	0.9666	More...
A6NEL2	Ankyrin repeat domain-containing protein SOWAHB	DEG_SPOP_SBC_1	738:742	VGSSS	SPOP	0.9911	More...
Q14582	Max dimerization protein 4	DEG_SPOP_SBC_1	174:178	VGSSS	SPOP	0.9872	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1545:1549	VGSSS	SPOP	0.8639	More...
Q8N5Q1	Golgi associated RAB2 interactor protein 5B	DEG_SPOP_SBC_1	869:873	VGSSS	SPOP	0.7404	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: VGSSS

Degron related mutations and impact score

Drug responses associated with TRIM37 mutations

All proteins holding degron of VGSSS