DegronMD - Q99590(SCAF11)

GO - Biological processes (BP): View more >>

GO - Molecular function (MF): View more >>

GO - Cellular component (CC): View more >>

Choose a PDB ID:
Open in full screen with detailed sequence annotations

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1006N	TCGA-17-Z026	LUAD	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation altering degron motif	0.6932
p.L1005P	TCGA-17-Z026	LUAD	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation altering degron motif	0.6471
p.D1009N	TCGA-55-8092	LUAD	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.25
p.D1009N	DO26220	LUAD	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.25
p.T996I	TCGA-AP-A051	UCEC	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.2222
p.T996I	DO42673	UCEC	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.2222
p.Y464H	TCGA-CG-4306	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1667
p.Y464H	DO38567	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.1667
p.K998N	TCGA-FI-A2D5	UCEC	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.2778
p.K998N	DO41331	UCEC	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.2778
p.L1005V	DO48442	BLCA	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation altering degron motif	0.5654
p.P1010Q	DO229032	LICA	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.2222
p.D1002E	DO229038	LICA	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation altering degron motif	0.5647
p.N1011D	SIDM00001	Other Blood Cancers	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.1944
p.N1011D	SIDM01117	Small Cell Lung Carcinoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.1944
p.N1011D	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.1944
p.N1011D	SIDM00195	Ewing's Sarcoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.1944
p.N1011D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.1944
p.N1011D	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.1944
p.D1006H	SIDM00217	Colorectal Carcinoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation altering degron motif	0.7688
p.D1006H	ACH-000999	Colon/Colorectal Cancer	CCLE	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation altering degron motif	0.7688
p.D1006H	SNU-1040	large intestine	COSMIC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation altering degron motif	0.7688
p.R997I	SIDM00534	Colorectal Carcinoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.25
p.R997I	ACH-000986	Colon/Colorectal Cancer	CCLE	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.25
p.R997I	HT-115	large intestine	COSMIC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.25
p.T1008S	HCT-15	large intestine	COSMIC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.2778
p.N474S	Farage	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.7069
p.R475Q	ESS-1	endometrium	COSMIC	VGSSS	DEG_SPOP_SBC_1	470:474	Mutation rewiring degron network	0.3056
p.H994R	NCI-H1944	lung	COSMIC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	1000:1006	Mutation rewiring degron network	0.1667
p.P472H	WSU-NHL	haematopoietic and lymphoid tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.7694
p.R473C	MFE-296	endometrium	COSMIC	VGSSS	DEG_SPOP_SBC_1	470:474	Mutation altering degron motif	0.8301

DegronMD: protein-targeted degradation, mutation and drug response to degrons

SCAF11

UniProt ID: Q99590

Entrez ID: 9169

External links: UniprotKB HGNC RefSeq COSMIC

Data table is loading....

Kaplan plot for SCAF11 in