DegronMD

Uniprot ID: Q99590

Source protein: Protein SCAF11

Source gene: SCAF11

Class: LIG_APCC_ABBAyCdc20_2

Location: 1000:1006

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8621

ASA_SCORE: 109.0571

COIL: 0.7719

CONS_SCORE: 0.3662

DSS_SCORE: 0.6747

HELIX: 0.2036

FCONS_SCORE: 0.8235

RIG_SCORE: 0.6887

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D1006N	TCGA-17-Z026	LUAD	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.6932
p.L1005P	TCGA-17-Z026	LUAD	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.6471
p.D1009N	TCGA-55-8092	LUAD	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.D1009N	DO26220	LUAD	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.T996I	TCGA-AP-A051	UCEC	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.T996I	DO42673	UCEC	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.K998N	TCGA-FI-A2D5	UCEC	TCGA	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.K998N	DO41331	UCEC	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.L1005V	DO48442	BLCA	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.5654
p.P1010Q	DO229032	LICA	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.2222
p.D1002E	DO229038	LICA	ICGC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.5647
p.N1011D	SIDM00001	Other Blood Cancers	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N1011D	SIDM01117	Small Cell Lung Carcinoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N1011D	SIDM00096	T-Cell Non-Hodgkin's Lymphoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N1011D	SIDM00195	Ewing's Sarcoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N1011D	SIDM00145	T-Lymphoblastic Leukemia	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.N1011D	SIDM00153	T-Lymphoblastic Leukemia	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D1006H	SIDM00217	Colorectal Carcinoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D1006H	ACH-000999	Colon/Colorectal Cancer	CCLE	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.7688
p.D1006H	SNU-1040	large_intestine	COSMIC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.7688
p.R997I	SIDM00534	Colorectal Carcinoma	GDSC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.R997I	ACH-000986	Colon/Colorectal Cancer	CCLE	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.R997I	HT-115	large_intestine	COSMIC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.25
p.T1008S	HCT-15	large_intestine	COSMIC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.2778
p.H994R	NCI-H1944	lung	COSMIC	KNDIHLD	LIG_APCC_ABBAyCdc20_2	0.1667

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: KNDIHLD

Degron related mutations and impact score

Drug responses associated with SCAF11 mutations

All proteins holding degron of KNDIHLD

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q99590	Protein SCAF11	LIG_APCC_ABBAyCdc20_2	1000:1006	KNDIHLD	APC,CDC20,FZR1	0.8621	More...