DegronMD - Q8IWI9(MGA)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.R1380Q	TCGA-09-0369	OV	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1111
p.R1380Q	TCGA-AA-3510	COAD	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1111
p.R1380Q	DO7783	COAD	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1111
p.R1380Q	DO30640	OV	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1111
p.P1772S	TCGA-12-0820	GBM	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.2222
p.P1772S	DO12838	GBM	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.2222
p.D2906E	TCGA-20-0991	OV	TCGA	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.3056
p.D2906E	DO31949	OV	ICGC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.3056
p.S1398F	TCGA-39-5016	LUSC	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1389
p.S1398F	DO26701	LUSC	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1389
p.R1383L	TCGA-44-8117	LUAD	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1944
p.R1383L	DO24028	LUAD	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1944
p.S1857L	TCGA-55-7574	LUAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2778
p.S1857L	TCGA-55-7574	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.3056
p.S1857L	TCGA-85-A4CL	LUSC	TCGA	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2778
p.S1857L	TCGA-85-A4CL	LUSC	TCGA	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.3056
p.S1857L	TCGA-EB-A5SE	SKCM	TCGA	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2778
p.S1857L	TCGA-EB-A5SE	SKCM	TCGA	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.3056
p.S1857L	DO23986	LUAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2778
p.S1857L	DO23986	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.3056
p.S1857L	DO45454	LUSC	ICGC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2778
p.S1857L	DO45454	LUSC	ICGC	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.3056
p.S1857L	DO47295	SKCM	ICGC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.2778
p.S1857L	DO47295	SKCM	ICGC	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.3056
p.N1865S	TCGA-69-A59K	LUAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.0556
p.N1865S	TCGA-69-A59K	LUAD	TCGA	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.0833
p.N1865S	TCGA-69-A59K	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.1667
p.N1865S	DO45335	LUAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.0556
p.N1865S	DO45335	LUAD	ICGC	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.0833
p.N1865S	DO45335	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.1667
p.Q1869E	TCGA-78-7156	LUAD	TCGA	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.2778
p.Q1869E	DO23720	LUAD	ICGC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.2778
p.R1775I	TCGA-78-7220	LUAD	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1389
p.R1775I	DO24409	LUAD	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1389
p.R1394C	TCGA-A1-A0SN	BRCA	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.25
p.R1394C	TCGA-VQ-A8PB	STAD	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.25
p.R1394C	DO4299	BRCA	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.25
p.R1394C	DO51766	STAD	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.25
p.T1851I	TCGA-A5-A0G1	UCEC	TCGA	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation altering degron motif	0.7078
p.T1851I	DO42472	UCEC	ICGC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation altering degron motif	0.7078
p.R1467C	TCGA-AA-3811	COAD	TCGA	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.2778
p.R1467C	DO7962	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.2778
p.R1467C	DO8858	COAD	ICGC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.2778
p.K1396E	TCGA-AA-3984	COAD	TCGA	PPVY	ITCH	1388:1391	Mutation substituting flanking lysine	0.3056
p.K1396E	DO9002	COAD	ICGC	PPVY	ITCH	1388:1391	Mutation substituting flanking lysine	0.3056
p.N1608K	TCGA-AO-A0JB	BRCA	TCGA	AVTTT	DEG_SPOP_SBC_1	1596:1600	Mutation rewiring degron network	0.1111
p.N1608K	DO5479	BRCA	ICGC	AVTTT	DEG_SPOP_SBC_1	1596:1600	Mutation rewiring degron network	0.1111
p.S1472I	TCGA-AP-A059	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.7341
p.S1472I	DO41361	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.7341
p.H1105Y	TCGA-AP-A0LF	UCEC	TCGA	RDPVFYD	LIG_APCC_ABBAyCdc20_2	1106:1112	Mutation rewiring degron network	0.3056
p.H1105Y	DO43610	UCEC	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	1106:1112	Mutation rewiring degron network	0.3056
p.A1876V	TCGA-AP-A1DK	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.3056
p.A1876V	DO42033	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.3056
p.V1578I	TCGA-AX-A1C5	UCEC	TCGA	MVVTPVVS	DEG_SCF_FBW7_1	1576:1583	Mutation altering degron motif	0.5965
p.V1578I	DO41422	UCEC	ICGC	MVVTPVVS	DEG_SCF_FBW7_1	1576:1583	Mutation altering degron motif	0.5965
p.R1383Q	TCGA-AX-A1C9	UCEC	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1944
p.R1383Q	DO43098	UCEC	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1944
p.S1378Y	TCGA-AX-A2HC	UCEC	TCGA	PPVY	ITCH	1388:1391	Mutation blocking phosphorylation signal	0.5
p.S1378Y	DO41572	UCEC	ICGC	PPVY	ITCH	1388:1391	Mutation blocking phosphorylation signal	0.5
p.S1392Y	TCGA-AX-A2HC	UCEC	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.3056
p.S1392Y	DO41572	UCEC	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.3056
p.T1268N	TCGA-B5-A3FC	UCEC	TCGA	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.0556
p.T1268N	DO41871	UCEC	ICGC	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.0556
p.I1723T	TCGA-BG-A222	UCEC	TCGA	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.1389
p.I1723T	DO42977	UCEC	ICGC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.1389
p.E1117D	TCGA-BR-6802	STAD	TCGA	RDPVFYD	LIG_APCC_ABBAyCdc20_2	1106:1112	Mutation rewiring degron network	0.1944
p.E1117D	DO38332	STAD	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	1106:1112	Mutation rewiring degron network	0.1944
p.E1607D	TCGA-BS-A0UV	UCEC	TCGA	AVTTT	DEG_SPOP_SBC_1	1596:1600	Mutation rewiring degron network	0.1389
p.E1607D	DO42793	UCEC	ICGC	AVTTT	DEG_SPOP_SBC_1	1596:1600	Mutation rewiring degron network	0.1389
p.D1112N	TCGA-D1-A1O7	UCEC	TCGA	RDPVFYD	LIG_APCC_ABBAyCdc20_2	1106:1112	Mutation altering degron motif	0.6932
p.D1112N	DO41139	UCEC	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	1106:1112	Mutation altering degron motif	0.6932
p.P1848L	TCGA-D5-6930	COAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation altering degron motif	0.6471
p.P1848L	DO10550	COAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation altering degron motif	0.6471
p.A1480T	TCGA-DF-A2KU	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.1389
p.A1480T	DO223286	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.1389
p.P1752H	TCGA-DJ-A2QB	THCA	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1111
p.P1752H	TCGA-DJ-A2QB	THCA	TCGA	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.3056
p.P1752H	DO39421	THCA	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1111
p.P1752H	DO39421	THCA	ICGC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.3056
p.D2895N	TCGA-DK-A2I4	BLCA	TCGA	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.1944
p.D2895N	DO465	BLCA	ICGC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.1944
p.S1474F	TCGA-EO-A22U	UCEC	TCGA	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.3056
p.S1474F	DO43755	UCEC	ICGC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.3056
p.P2600L	TCGA-EO-A22X	UCEC	TCGA	PLNTPHTS	DEG_SCF_FBW7_1	2586:2593	Mutation rewiring degron network	0.1389
p.P2600L	TCGA-IB-7651	PAAD	TCGA	PLNTPHTS	DEG_SCF_FBW7_1	2586:2593	Mutation rewiring degron network	0.1389
p.P2600L	DO46657	PAAD	ICGC	PLNTPHTS	DEG_SCF_FBW7_1	2586:2593	Mutation rewiring degron network	0.1389
p.P2600L	DO43907	UCEC	ICGC	PLNTPHTS	DEG_SCF_FBW7_1	2586:2593	Mutation rewiring degron network	0.1389
p.L2904S	TCGA-EO-A3AV	UCEC	TCGA	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation altering degron motif	0.6556
p.L2904S	DO52412	UCEC	ICGC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation altering degron motif	0.6556
p.P1574L	TCGA-ER-A42L	SKCM	TCGA	MVVTPVVS	DEG_SCF_FBW7_1	1576:1583	Mutation rewiring degron network	0.2778
p.P1574L	DO223910	SKCM	ICGC	MVVTPVVS	DEG_SCF_FBW7_1	1576:1583	Mutation rewiring degron network	0.2778
p.M1399I	TCGA-EY-A1GK	UCEC	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1111
p.M1399I	DO42985	UCEC	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1111
p.V1879A	TCGA-F5-6814	READ	TCGA	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.2222
p.V1879A	DO36556	READ	ICGC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.2222
p.P1469H	TCGA-FS-A1ZP	SKCM	TCGA	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.7694
p.P1469H	DO37703	SKCM	ICGC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.7694
p.S1398C	TCGA-G2-A2EO	BLCA	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1389
p.S1398C	DO456	BLCA	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1389
p.R1841W	TCGA-G4-6628	COAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1389
p.R1841W	TCGA-XK-AAIW	PRAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1389
p.R1841W	DO10132	COAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1389
p.R1841W	DO51407	PRAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1389
p.P1260T	TCGA-HE-7128	KIRP	TCGA	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.2778
p.P1260T	DO20796	KIRP	ICGC	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.2778
p.S1873Y	TCGA-IN-A6RO	STAD	TCGA	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation altering degron motif	0.712
p.S1873Y	DO51740	STAD	ICGC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation altering degron motif	0.712
p.L1764F	TCGA-L5-A8NK	ESCA	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation altering degron motif	0.6981
p.G1384C	TCGA-L9-A444	LUAD	TCGA	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.2222
p.G1384C	DO228978	LICA	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.2222
p.G1384C	DO26015	LUAD	ICGC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.2222
p.L2900F	TCGA-Q1-A5R2	CESC	TCGA	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation altering degron motif	0.587
p.L2900F	DO49003	CESC	ICGC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation altering degron motif	0.587
p.T1754A	TCGA-UC-A7PG	CESC	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1667
p.T1754A	TCGA-UC-A7PG	CESC	TCGA	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.T1754A	DO51615	CESC	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1667
p.T1754A	DO51615	CESC	ICGC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.K1248T	TCGA-UY-A8OB	BLCA	TCGA	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation substituting flanking lysine	0.2778
p.K1248T	DO219037	BLCA	ICGC	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation substituting flanking lysine	0.2778
p.P1752T	TCGA-VQ-A8P2	STAD	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1111
p.P1752T	TCGA-VQ-A8P2	STAD	TCGA	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.3056
p.P1752T	DO51761	STAD	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1111
p.P1752T	DO51761	STAD	ICGC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.3056
p.A2594V	DO222492	COCA	ICGC	PLNTPHTS	DEG_SCF_FBW7_1	2586:2593	Mutation rewiring degron network	0.3056
p.S1472C	DO50372	ESAD	ICGC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.7541
p.F1264I	DO233677	GACA	ICGC	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.1667
p.E1122K	DO233686	GACA	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	1106:1112	Mutation rewiring degron network	0.0556
p.A1758S	DO229032	LICA	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.2778
p.A1758S	DO229032	LICA	ICGC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1389
p.V1390F	DO229037	LICA	ICGC	PPVY	ITCH	1388:1391	Mutation altering degron motif	0.5957
p.K1386N	DO229041	LICA	ICGC	PPVY	ITCH	1388:1391	Mutation blocking ubiquitination signal	0.7222
p.T1268A	DO23544	LIRI	ICGC	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.0556
p.D2908N	DO231075	LUSC	ICGC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.25
p.P1108S	DO220880	MELA	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	1106:1112	Mutation altering degron motif	0.5641
p.L1476R	DO51150	PRAD	ICGC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.25
p.S2898G	SIDM02021	Esophageal Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation blocking phosphorylation signal	0.7222
p.A1860V	SIDM00683	Prostate Carcinoma	GDSC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1944
p.A1860V	SIDM00683	Prostate Carcinoma	GDSC	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.2222
p.A1860V	ACH-000977	lymph node	CCLE	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1944
p.A1860V	ACH-000977	lymph node	CCLE	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.2222
p.A1860V	LNCaP-Clone-FGC	prostate	COSMIC	PSETPPSS	DEG_SCF_FBW7_1	1848:1855	Mutation rewiring degron network	0.1944
p.A1860V	LNCaP-Clone-FGC	prostate	COSMIC	PPSST	DEG_SPOP_SBC_1	1852:1856	Mutation rewiring degron network	0.2222
p.S1751F	SIDM00545	Melanoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.7982
p.S1751F	ACH-000987	Skin Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.7982
p.S1751F	Mewo	skin	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.7982
p.N1387T	SIDM00845	Burkitt's Lymphoma	GDSC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.3056
p.N1387T	SIDM00035	Thyroid Gland Carcinoma	GDSC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.3056
p.N1387T	ACH-000786	Lymphoma	CCLE	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.3056
p.N1387T	ACH-000992	Head and Neck Cancer	CCLE	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.3056
p.N1387T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.3056
p.A1459S	SIDM00845	Burkitt's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	SIDM00035	Thyroid Gland Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	SIDM00461	Acute Myeloid Leukemia	GDSC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	SIDM01519	Head and Neck Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	ACH-000037	Sarcoma	CCLE	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	ACH-000786	Lymphoma	CCLE	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	ACH-000992	Head and Neck Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	ACH-001067	Brain Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	OCI-AML5	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.A1459S	S-117	soft tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation rewiring degron network	0.0556
p.S1472T	SIDM00845	Burkitt's Lymphoma	GDSC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.6005
p.S1472T	SIDM01519	Head and Neck Carcinoma	GDSC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.6005
p.S1472T	ACH-000037	Sarcoma	CCLE	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.6005
p.S1472T	ACH-000786	Lymphoma	CCLE	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.6005
p.S1472T	ACH-000992	Head and Neck Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.6005
p.S1472T	ACH-001067	Brain Cancer	CCLE	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.6005
p.S1472T	Daudi	haematopoietic and lymphoid tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.6005
p.S1472T	S-117	soft tissue	COSMIC	PSSST	DEG_SPOP_SBC_1	1469:1473	Mutation altering degron motif	0.6005
p.P1586Q	SIDM00845	Burkitt's Lymphoma	GDSC	MVVTPVVS	DEG_SCF_FBW7_1	1576:1583	Mutation rewiring degron network	0.25
p.P1586Q	SIDM00845	Burkitt's Lymphoma	GDSC	AVTTT	DEG_SPOP_SBC_1	1596:1600	Mutation rewiring degron network	0.0556
p.A1758T	SIDM00845	Burkitt's Lymphoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.2778
p.A1758T	SIDM00845	Burkitt's Lymphoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1389
p.V2890I	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.0556
p.V2890I	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.0556
p.V2890I	SIDM00410	Other Blood Cancers	GDSC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.0556
p.V2890I	SIDM01435	Hepatocellular Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.0556
p.E2893A	SIDM01062	Breast Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.1389
p.E2893A	SIDM00230	Small Cell Lung Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	2900:2905	Mutation rewiring degron network	0.1389
p.T1711I	SIDM01117	Small Cell Lung Carcinoma	GDSC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.5966
p.T1711I	ACH-002176	Lung Cancer	CCLE	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.5966
p.T1711I	NCI-H748	lung	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.5966
p.V1700M	SIDM00600	Thyroid Gland Carcinoma	GDSC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.0833
p.V1700M	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.0833
p.V1700M	SLVL	haematopoietic and lymphoid tissue	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.0833
p.V1700M	IHH-4	thyroid	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.0833
p.N1739T	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1944
p.N1739T	ACH-000667	Lung Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1944
p.N1739T	HCC-44	lung	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1944
p.A1758G	SIDM00950	Pancreatic Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.2778
p.A1758G	SIDM00950	Pancreatic Carcinoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1389
p.A1758G	ACH-000243	Pancreatic Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.2778
p.A1758G	ACH-000243	Pancreatic Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1389
p.A1758G	DAN-G	pancreas	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.2778
p.A1758G	DAN-G	pancreas	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1389
p.L1762M	SIDM00477	Esophageal Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation altering degron motif	0.5999
p.L1762M	ACH-000383	Esophageal Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation altering degron motif	0.5999
p.L1762M	OE33	oesophagus	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation altering degron motif	0.5999
p.V1767M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation altering degron motif	0.6097
p.V1767M	ACH-002238	Leukemia	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation altering degron motif	0.6097
p.V1767M	GR-ST	haematopoietic and lymphoid tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation altering degron motif	0.6097
p.E1245G	SIDM00687	Gastric Carcinoma	GDSC	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.0833
p.E1245G	ACH-000793	Gastric Cancer	CCLE	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.0833
p.E1245G	KATOIII	stomach	COSMIC	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.0833
p.T1609A	SIDM00014	Colorectal Carcinoma	GDSC	AVTTT	DEG_SPOP_SBC_1	1596:1600	Mutation rewiring degron network	0.0833
p.T1609A	LIM1215	large intestine	COSMIC	AVTTT	DEG_SPOP_SBC_1	1596:1600	Mutation rewiring degron network	0.0833
p.Q1882E	SIDM00249	Esophageal Squamous Cell Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.1389
p.Q1882E	ACH-000353	Esophageal Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.1389
p.Q1882E	TE-15	oesophagus	COSMIC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.1389
p.R1757H	SIDM00999	Bladder Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.25
p.R1757H	SIDM00999	Bladder Carcinoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1667
p.R1757H	ACH-000973	Bladder Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.25
p.R1757H	ACH-000973	Bladder Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1667
p.R1757H	639-V	urinary tract	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.25
p.R1757H	639-V	urinary tract	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.1667
p.P1776S	SIDM00217	Colorectal Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1111
p.P1776S	ACH-000999	Colon/Colorectal Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1111
p.P1776S	SNU-1040	large intestine	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1111
p.V1710E	SIDM00256	Neuroblastoma	GDSC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.6582
p.V1710E	ACH-002281	Neuroblastoma	CCLE	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.6582
p.V1710E	NB14	autonomic ganglia	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation altering degron motif	0.6582
p.P1400S	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.0833
p.P1400S	ACH-002222	Leukemia	CCLE	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.0833
p.P1400S	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.0833
p.T1754R	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1667
p.T1754R	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.T1754R	ACH-002222	Leukemia	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1667
p.T1754R	ACH-002222	Leukemia	CCLE	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.T1754R	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.1667
p.T1754R	CTV-1	haematopoietic and lymphoid tissue	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation rewiring degron network	0.25
p.S1259F	ACH-000854	Myeloma	CCLE	PSSSS	DEG_SPOP_SBC_1	1254:1258	Mutation rewiring degron network	0.3056
p.S1751P	ACH-001282	Bone Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	1744:1751	Mutation altering degron motif	0.6752
p.Y1391F	ACH-002213	Head and Neck Cancer	CCLE	PPVY	ITCH	1388:1391	Mutation altering degron motif	0.7528
p.Y1391F	BB49-HNC	upper aerodigestive tract	COSMIC	PPVY	ITCH	1388:1391	Mutation altering degron motif	0.7528
p.A1725D	TOV-21G	ovary	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.0833
p.E1876D	639-V	urinary tract	COSMIC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation rewiring degron network	0.3056
p.S1382C	Daudi	haematopoietic and lymphoid tissue	COSMIC	PPVY	ITCH	1388:1391	Mutation rewiring degron network	0.1667
p.A1873V	SW684	soft tissue	COSMIC	VGSSS	DEG_SPOP_SBC_1	1871:1875	Mutation altering degron motif	0.6936
p.S2598G	COLO-684	endometrium	COSMIC	PLNTPHTS	DEG_SCF_FBW7_1	2586:2593	Mutation rewiring degron network	0.1944
p.Q1572L	RERF-LC-KJ	lung	COSMIC	MVVTPVVS	DEG_SCF_FBW7_1	1576:1583	Mutation rewiring degron network	0.2222
p.E1771K	BT-474	breast	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.25
p.H1606R	H2869	pleura	COSMIC	AVTTT	DEG_SPOP_SBC_1	1596:1600	Mutation rewiring degron network	0.1667
p.K1769R	ALL-SIL	haematopoietic and lymphoid tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.3056
p.G1719R	COR-L95	lung	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.25
p.S1702R	IMR-5	autonomic ganglia	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	1709:1716	Mutation rewiring degron network	0.1389
p.D1770E	KYSE-140	oesophagus	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	1760:1768	Mutation rewiring degron network	0.2778
p.P1567S	SNU-1040	large intestine	COSMIC	MVVTPVVS	DEG_SCF_FBW7_1	1576:1583	Mutation substituting flanking lysine	0.1944

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MGA

UniProt ID: Q8IWI9

Entrez ID: 23269

Protein name: MAX gene-associated protein (MAX dimerization protein 5)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MGA in