DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: LIG_APCC_ABBA_1

Location: 2900:2905

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.6667

ASA_SCORE: 43.0167

COIL: 0.3098

CONS_SCORE: 0.5326

DSS_SCORE: 0.5366

HELIX: 0.0262

FCONS_SCORE: 0.9259

RIG_SCORE: 0.7605

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.D2906E	TCGA-20-0991	OV	TCGA	LLLHLE	LIG_APCC_ABBA_1	0.3056
p.D2906E	DO31949	OV	ICGC	LLLHLE	LIG_APCC_ABBA_1	0.3056
p.D2895N	TCGA-DK-A2I4	BLCA	TCGA	LLLHLE	LIG_APCC_ABBA_1	0.1944
p.D2895N	DO465	BLCA	ICGC	LLLHLE	LIG_APCC_ABBA_1	0.1944
p.L2904S	TCGA-EO-A3AV	UCEC	TCGA	LLLHLE	LIG_APCC_ABBA_1	0.6556
p.L2904S	DO52412	UCEC	ICGC	LLLHLE	LIG_APCC_ABBA_1	0.6556
p.L2900F	TCGA-Q1-A5R2	CESC	TCGA	LLLHLE	LIG_APCC_ABBA_1	0.587
p.L2900F	DO49003	CESC	ICGC	LLLHLE	LIG_APCC_ABBA_1	0.587
p.D2908N	DO231075	LUSC	ICGC	LLLHLE	LIG_APCC_ABBA_1	0.25
p.S2898G	SIDM02021	Esophageal Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	0.7222
p.V2890I	SIDM00297	Non-Small Cell Lung Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	0.0556
p.V2890I	SIDM00598	Squamous Cell Lung Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	0.0556
p.V2890I	SIDM00410	Other Blood Cancers	GDSC	LLLHLE	LIG_APCC_ABBA_1	0.0556
p.V2890I	SIDM01435	Hepatocellular Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	0.0556
p.E2893A	SIDM01062	Breast Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	0.1389
p.E2893A	SIDM00230	Small Cell Lung Carcinoma	GDSC	LLLHLE	LIG_APCC_ABBA_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	LIG_APCC_ABBA_1	2900:2905	LLLHLE	APC,CDC20,FZR1	0.6667	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons