DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: DEG_SCF_FBW7_1

Location: 2586:2593

E3 ligase: FBXW7

DEGRON score: 0.9631

ASA_SCORE: 89.9375

COIL: 0.9106

CONS_SCORE: 0.6104

DSS_SCORE: 0.6117

HELIX: 0.0396

FCONS_SCORE: 0.9723

RIG_SCORE: 0.6665

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P2600L	TCGA-EO-A22X	UCEC	TCGA	PLNTPHTS	DEG_SCF_FBW7_1	0.1389
p.P2600L	TCGA-IB-7651	PAAD	TCGA	PLNTPHTS	DEG_SCF_FBW7_1	0.1389
p.P2600L	DO46657	PAAD	ICGC	PLNTPHTS	DEG_SCF_FBW7_1	0.1389
p.P2600L	DO43907	UCEC	ICGC	PLNTPHTS	DEG_SCF_FBW7_1	0.1389
p.A2594V	DO222492	COCA	ICGC	PLNTPHTS	DEG_SCF_FBW7_1	0.3056
p.S2598G	COLO-684	endometrium	COSMIC	PLNTPHTS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	DEG_SCF_FBW7_1	2586:2593	PLNTPHTS	FBXW7	0.9631	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons