DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: DEG_APCC_DBOX_1

Location: 1760:1768

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.759

ASA_SCORE: 86.3667

COIL: 0.7292

CONS_SCORE: 0.6366

DSS_SCORE: 0.4934

HELIX: 0.0478

FCONS_SCORE: 1.0664

RIG_SCORE: 0.7751

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1772S	TCGA-12-0820	GBM	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2222
p.P1772S	DO12838	GBM	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2222
p.R1775I	TCGA-78-7220	LUAD	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1389
p.R1775I	DO24409	LUAD	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1389
p.P1752H	TCGA-DJ-A2QB	THCA	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1111
p.P1752H	DO39421	THCA	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1111
p.L1764F	TCGA-L5-A8NK	ESCA	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.6981
p.T1754A	TCGA-UC-A7PG	CESC	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.T1754A	DO51615	CESC	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.P1752T	TCGA-VQ-A8P2	STAD	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1111
p.P1752T	DO51761	STAD	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1111
p.A1758S	DO229032	LICA	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.A1758T	SIDM00845	Burkitt's Lymphoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.A1758G	SIDM00950	Pancreatic Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.A1758G	ACH-000243	Pancreatic Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.A1758G	DAN-G	pancreas	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.L1762M	SIDM00477	Esophageal Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.5999
p.L1762M	ACH-000383	Esophageal Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.5999
p.L1762M	OE33	oesophagus	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.5999
p.V1767M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.6097
p.V1767M	ACH-002238	Leukemia	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.6097
p.V1767M	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.6097
p.R1757H	SIDM00999	Bladder Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.25
p.R1757H	ACH-000973	Bladder Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.25
p.R1757H	639-V	urinary_tract	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.25
p.P1776S	SIDM00217	Colorectal Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1111
p.P1776S	ACH-000999	Colon/Colorectal Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1111
p.P1776S	SNU-1040	large_intestine	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1111
p.T1754R	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.T1754R	ACH-002222	Leukemia	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.T1754R	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.E1771K	BT-474	breast	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.25
p.K1769R	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.3056
p.D1770E	KYSE-140	oesophagus	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRLLLIPVQ

Degron related mutations and impact score

Drug responses associated with MGA mutations

All proteins holding degron of PRLLLIPVQ

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	DEG_APCC_DBOX_1	1760:1768	PRLLLIPVQ	APC,CDC20,FZR1	0.759	More...