DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: DEG_APCC_DBOX_1

Location: 1760:1768

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.759

ASA_SCORE: 86.3667

COIL: 0.7292

CONS_SCORE: 0.6366

DSS_SCORE: 0.4934

HELIX: 0.0478

FCONS_SCORE: 1.0664

RIG_SCORE: 0.7751

Degron related mutations and impact score

Show entries

Search:

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.L1764F	TCGA-L5-A8NK	ESCA	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.6981
p.V1767M	SIDM01259	B-Lymphoblastic Leukemia	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.6097
p.V1767M	ACH-002238	Leukemia	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.6097
p.V1767M	GR-ST	haematopoietic_and_lymphoid_tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.6097
p.L1762M	SIDM00477	Esophageal Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.5999
p.L1762M	ACH-000383	Esophageal Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.5999
p.L1762M	OE33	oesophagus	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.5999
p.K1769R	ALL-SIL	haematopoietic_and_lymphoid_tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.3056
p.A1758S	DO229032	LICA	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.A1758T	SIDM00845	Burkitt's Lymphoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.A1758G	SIDM00950	Pancreatic Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.A1758G	ACH-000243	Pancreatic Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.A1758G	DAN-G	pancreas	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.D1770E	KYSE-140	oesophagus	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2778
p.R1757H	SIDM00999	Bladder Carcinoma	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.25
p.R1757H	ACH-000973	Bladder Cancer	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.25
p.R1757H	639-V	urinary_tract	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.25
p.E1771K	BT-474	breast	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.25
p.P1772S	TCGA-12-0820	GBM	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2222
p.P1772S	DO12838	GBM	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.2222
p.T1754A	TCGA-UC-A7PG	CESC	TCGA	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.T1754A	DO51615	CESC	ICGC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.T1754R	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.T1754R	ACH-002222	Leukemia	CCLE	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667
p.T1754R	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PRLLLIPVQ	DEG_APCC_DBOX_1	0.1667

Showing 1 to 25 of 34 entries

Previous1 2Next

Drug responses associated with MGA mutations

Show entries

Search:

Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
No data available in table

Showing 0 to 0 of 0 entries

PreviousNext

All proteins holding degron of PRLLLIPVQ

Show entries

Search:

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	DEG_APCC_DBOX_1	1760:1768	PRLLLIPVQ	APC,CDC20,FZR1	0.759	More...

Showing 1 to 1 of 1 entries

Previous1Next

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PRLLLIPVQ

Degron related mutations and impact score

Drug responses associated with MGA mutations

All proteins holding degron of PRLLLIPVQ