DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
PSETPPSS
Uniprot ID:
Q8IWI9
Source protein:
MAX gene-associated protein
Source gene:
MGA
Class:
DEG_SCF_FBW7_1
Location:
1848:1855
E3 ligase:
FBXW7
DEGRON score:
0.5946
ASA_SCORE:
92.925
COIL:
0.9551
CONS_SCORE:
0.5662
DSS_SCORE:
0.6344
HELIX:
0.0214
FCONS_SCORE:
0.9632
RIG_SCORE:
0.5492
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.S1857L
TCGA-55-7574
LUAD
TCGA
PSETPPSS
DEG_SCF_FBW7_1
0.2778
p.S1857L
TCGA-85-A4CL
LUSC
TCGA
PSETPPSS
DEG_SCF_FBW7_1
0.2778
p.S1857L
TCGA-EB-A5SE
SKCM
TCGA
PSETPPSS
DEG_SCF_FBW7_1
0.2778
p.S1857L
DO23986
LUAD
ICGC
PSETPPSS
DEG_SCF_FBW7_1
0.2778
p.S1857L
DO45454
LUSC
ICGC
PSETPPSS
DEG_SCF_FBW7_1
0.2778
p.S1857L
DO47295
SKCM
ICGC
PSETPPSS
DEG_SCF_FBW7_1
0.2778
p.N1865S
TCGA-69-A59K
LUAD
TCGA
PSETPPSS
DEG_SCF_FBW7_1
0.0556
p.N1865S
DO45335
LUAD
ICGC
PSETPPSS
DEG_SCF_FBW7_1
0.0556
p.T1851I
TCGA-A5-A0G1
UCEC
TCGA
PSETPPSS
DEG_SCF_FBW7_1
0.7078
p.T1851I
DO42472
UCEC
ICGC
PSETPPSS
DEG_SCF_FBW7_1
0.7078
p.P1848L
TCGA-D5-6930
COAD
TCGA
PSETPPSS
DEG_SCF_FBW7_1
0.6471
p.P1848L
DO10550
COAD
ICGC
PSETPPSS
DEG_SCF_FBW7_1
0.6471
p.R1841W
TCGA-G4-6628
COAD
TCGA
PSETPPSS
DEG_SCF_FBW7_1
0.1389
p.R1841W
TCGA-XK-AAIW
PRAD
TCGA
PSETPPSS
DEG_SCF_FBW7_1
0.1389
p.R1841W
DO10132
COAD
ICGC
PSETPPSS
DEG_SCF_FBW7_1
0.1389
p.R1841W
DO51407
PRAD
ICGC
PSETPPSS
DEG_SCF_FBW7_1
0.1389
p.A1860V
SIDM00683
Prostate Carcinoma
GDSC
PSETPPSS
DEG_SCF_FBW7_1
0.1944
p.A1860V
ACH-000977
lymph_node
CCLE
PSETPPSS
DEG_SCF_FBW7_1
0.1944
p.A1860V
LNCaP-Clone-FGC
prostate
COSMIC
PSETPPSS
DEG_SCF_FBW7_1
0.1944
Drug responses associated with MGA mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of PSETPPSS
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
Q8IWI9
MAX gene-associated protein
DEG_SCF_FBW7_1
1848:1855
PSETPPSS
FBXW7
0.5946
More...