DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: DEG_SCF_FBW7_1

Location: 1848:1855

E3 ligase: FBXW7

DEGRON score: 0.5946

ASA_SCORE: 92.925

COIL: 0.9551

CONS_SCORE: 0.5662

DSS_SCORE: 0.6344

HELIX: 0.0214

FCONS_SCORE: 0.9632

RIG_SCORE: 0.5492

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Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.T1851I	TCGA-A5-A0G1	UCEC	TCGA	PSETPPSS	DEG_SCF_FBW7_1	0.7078
p.T1851I	DO42472	UCEC	ICGC	PSETPPSS	DEG_SCF_FBW7_1	0.7078
p.P1848L	TCGA-D5-6930	COAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	0.6471
p.P1848L	DO10550	COAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	0.6471
p.S1857L	TCGA-55-7574	LUAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	0.2778
p.S1857L	TCGA-85-A4CL	LUSC	TCGA	PSETPPSS	DEG_SCF_FBW7_1	0.2778
p.S1857L	TCGA-EB-A5SE	SKCM	TCGA	PSETPPSS	DEG_SCF_FBW7_1	0.2778
p.S1857L	DO23986	LUAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	0.2778
p.S1857L	DO45454	LUSC	ICGC	PSETPPSS	DEG_SCF_FBW7_1	0.2778
p.S1857L	DO47295	SKCM	ICGC	PSETPPSS	DEG_SCF_FBW7_1	0.2778
p.A1860V	SIDM00683	Prostate Carcinoma	GDSC	PSETPPSS	DEG_SCF_FBW7_1	0.1944
p.A1860V	ACH-000977	lymph_node	CCLE	PSETPPSS	DEG_SCF_FBW7_1	0.1944
p.A1860V	LNCaP-Clone-FGC	prostate	COSMIC	PSETPPSS	DEG_SCF_FBW7_1	0.1944
p.R1841W	TCGA-G4-6628	COAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	0.1389
p.R1841W	TCGA-XK-AAIW	PRAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	0.1389
p.R1841W	DO10132	COAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	0.1389
p.R1841W	DO51407	PRAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	0.1389
p.N1865S	TCGA-69-A59K	LUAD	TCGA	PSETPPSS	DEG_SCF_FBW7_1	0.0556
p.N1865S	DO45335	LUAD	ICGC	PSETPPSS	DEG_SCF_FBW7_1	0.0556

Showing 1 to 19 of 19 entries

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Sample	Cancer	Mutation (In Degron?)	Dataset	Drug	IC50
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Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	DEG_SCF_FBW7_1	1848:1855	PSETPPSS	FBXW7	0.5946	More...

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DegronMD: protein-targeted degradation, mutation and drug response to degrons