DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: DEG_SCF_FBW7_1

Location: 1744:1751

E3 ligase: FBXW7

DEGRON score: 0.989

ASA_SCORE: 80.5375

COIL: 0.9008

CONS_SCORE: 0.5509

DSS_SCORE: 0.5515

HELIX: 0.0128

FCONS_SCORE: 0.9652

RIG_SCORE: 0.702

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.P1752H	TCGA-DJ-A2QB	THCA	TCGA	PVATPQVS	DEG_SCF_FBW7_1	0.3056
p.P1752H	DO39421	THCA	ICGC	PVATPQVS	DEG_SCF_FBW7_1	0.3056
p.T1754A	TCGA-UC-A7PG	CESC	TCGA	PVATPQVS	DEG_SCF_FBW7_1	0.25
p.T1754A	DO51615	CESC	ICGC	PVATPQVS	DEG_SCF_FBW7_1	0.25
p.P1752T	TCGA-VQ-A8P2	STAD	TCGA	PVATPQVS	DEG_SCF_FBW7_1	0.3056
p.P1752T	DO51761	STAD	ICGC	PVATPQVS	DEG_SCF_FBW7_1	0.3056
p.A1758S	DO229032	LICA	ICGC	PVATPQVS	DEG_SCF_FBW7_1	0.1389
p.S1751F	SIDM00545	Melanoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	0.7982
p.S1751F	ACH-000987	Skin Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	0.7982
p.S1751F	Mewo	skin	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	0.7982
p.A1758T	SIDM00845	Burkitt's Lymphoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	0.1389
p.N1739T	SIDM01069	Non-Small Cell Lung Carcinoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	0.1944
p.N1739T	ACH-000667	Lung Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	0.1944
p.N1739T	HCC-44	lung	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	0.1944
p.A1758G	SIDM00950	Pancreatic Carcinoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	0.1389
p.A1758G	ACH-000243	Pancreatic Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	0.1389
p.A1758G	DAN-G	pancreas	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	0.1389
p.R1757H	SIDM00999	Bladder Carcinoma	GDSC	PVATPQVS	DEG_SCF_FBW7_1	0.1667
p.R1757H	ACH-000973	Bladder Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	0.1667
p.R1757H	639-V	urinary_tract	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	0.1667
p.T1754R	SIDM00951	T-Lymphoblastic Leukemia	GDSC	PVATPQVS	DEG_SCF_FBW7_1	0.25
p.T1754R	ACH-002222	Leukemia	CCLE	PVATPQVS	DEG_SCF_FBW7_1	0.25
p.T1754R	CTV-1	haematopoietic_and_lymphoid_tissue	COSMIC	PVATPQVS	DEG_SCF_FBW7_1	0.25
p.S1751P	ACH-001282	Bone Cancer	CCLE	PVATPQVS	DEG_SCF_FBW7_1	0.6752

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	DEG_SCF_FBW7_1	1744:1751	PVATPQVS	FBXW7	0.989	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PVATPQVS

Degron related mutations and impact score

Drug responses associated with MGA mutations

All proteins holding degron of PVATPQVS