DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: DEG_SCF_FBW7_1

Location: 1709:1716

E3 ligase: FBXW7

DEGRON score: 0.9157

ASA_SCORE: 83.5875

COIL: 0.856

CONS_SCORE: 0.6025

DSS_SCORE: 0.2792

HELIX: 0.0243

FCONS_SCORE: 1.0785

RIG_SCORE: 0.7249

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.I1723T	TCGA-BG-A222	UCEC	TCGA	MVTTPTSS	DEG_SCF_FBW7_1	0.1389
p.I1723T	DO42977	UCEC	ICGC	MVTTPTSS	DEG_SCF_FBW7_1	0.1389
p.T1711I	SIDM01117	Small Cell Lung Carcinoma	GDSC	MVTTPTSS	DEG_SCF_FBW7_1	0.5966
p.T1711I	ACH-002176	Lung Cancer	CCLE	MVTTPTSS	DEG_SCF_FBW7_1	0.5966
p.T1711I	NCI-H748	lung	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	0.5966
p.V1700M	SIDM00600	Thyroid Gland Carcinoma	GDSC	MVTTPTSS	DEG_SCF_FBW7_1	0.0833
p.V1700M	SIDM00374	B-Cell Non-Hodgkin's Lymphoma	GDSC	MVTTPTSS	DEG_SCF_FBW7_1	0.0833
p.V1700M	SLVL	haematopoietic_and_lymphoid_tissue	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	0.0833
p.V1700M	IHH-4	thyroid	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	0.0833
p.V1710E	SIDM00256	Neuroblastoma	GDSC	MVTTPTSS	DEG_SCF_FBW7_1	0.6582
p.V1710E	ACH-002281	Neuroblastoma	CCLE	MVTTPTSS	DEG_SCF_FBW7_1	0.6582
p.V1710E	NB14	autonomic_ganglia	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	0.6582
p.A1725D	TOV-21G	ovary	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	0.0833
p.G1719R	COR-L95	lung	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	0.25
p.S1702R	IMR-5	autonomic_ganglia	COSMIC	MVTTPTSS	DEG_SCF_FBW7_1	0.1389

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	DEG_SCF_FBW7_1	1709:1716	MVTTPTSS	FBXW7	0.9157	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons