DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: LIG_APCC_ABBAyCdc20_2

Location: 1106:1112

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.8463

ASA_SCORE: 85.1857

COIL: 0.6627

CONS_SCORE: 0.5642

DSS_SCORE: 0.4437

HELIX: 0.2367

FCONS_SCORE: 1.087

RIG_SCORE: 0.7691

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.H1105Y	TCGA-AP-A0LF	UCEC	TCGA	RDPVFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.H1105Y	DO43610	UCEC	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	0.3056
p.E1117D	TCGA-BR-6802	STAD	TCGA	RDPVFYD	LIG_APCC_ABBAyCdc20_2	0.1944
p.E1117D	DO38332	STAD	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	0.1944
p.D1112N	TCGA-D1-A1O7	UCEC	TCGA	RDPVFYD	LIG_APCC_ABBAyCdc20_2	0.6932
p.D1112N	DO41139	UCEC	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	0.6932
p.E1122K	DO233686	GACA	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	0.0556
p.P1108S	DO220880	MELA	ICGC	RDPVFYD	LIG_APCC_ABBAyCdc20_2	0.5641

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	LIG_APCC_ABBAyCdc20_2	1106:1112	RDPVFYD	APC,CDC20,FZR1	0.8463	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons