DegronMD

Uniprot ID: Q8IWI9

Source protein: MAX gene-associated protein

Source gene: MGA

Class: DEG_SCF_FBW7_1

Location: 1576:1583

E3 ligase: FBXW7

DEGRON score: 0.9966

ASA_SCORE: 79.575

COIL: 0.8075

CONS_SCORE: 0.5598

DSS_SCORE: 0.2816

HELIX: 0.0206

FCONS_SCORE: 1.0203

RIG_SCORE: 0.792

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.V1578I	TCGA-AX-A1C5	UCEC	TCGA	MVVTPVVS	DEG_SCF_FBW7_1	0.5965
p.V1578I	DO41422	UCEC	ICGC	MVVTPVVS	DEG_SCF_FBW7_1	0.5965
p.P1574L	TCGA-ER-A42L	SKCM	TCGA	MVVTPVVS	DEG_SCF_FBW7_1	0.2778
p.P1574L	DO223910	SKCM	ICGC	MVVTPVVS	DEG_SCF_FBW7_1	0.2778
p.P1586Q	SIDM00845	Burkitt's Lymphoma	GDSC	MVVTPVVS	DEG_SCF_FBW7_1	0.25
p.Q1572L	RERF-LC-KJ	lung	COSMIC	MVVTPVVS	DEG_SCF_FBW7_1	0.2222
p.P1567S	SNU-1040	large_intestine	COSMIC	MVVTPVVS	DEG_SCF_FBW7_1	0.1944

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q8IWI9	MAX gene-associated protein	DEG_SCF_FBW7_1	1576:1583	MVVTPVVS	FBXW7	0.9966	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons