DegronMD - Q92576(PHF3)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.D1671N	TCGA-17-Z031	LUAD	TCGA	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.1667
p.T428S	TCGA-44-A4SS	LUAD	TCGA	VDTST	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.6005
p.T428S	DO24227	LUAD	ICGC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.6005
p.R1674W	TCGA-50-5935	LUAD	TCGA	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.0833
p.R1674W	DO23588	LUAD	ICGC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.0833
p.K418E	TCGA-A6-6142	COAD	TCGA	VDTST	DEG_SPOP_SBC_1	424:428	Mutation substituting flanking lysine	0.2778
p.K418E	DO9988	COAD	ICGC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation substituting flanking lysine	0.2778
p.S188P	TCGA-AA-A00N	COAD	TCGA	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.1667
p.S188P	DO9876	COAD	ICGC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.1667
p.I435T	TCGA-AA-A010	COAD	TCGA	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1389
p.R202Q	TCGA-AN-A046	BRCA	TCGA	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.2222
p.R202Q	DO1285	BRCA	ICGC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.2222
p.R202Q	SIDM01088	Endometrial Carcinoma	GDSC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.2222
p.R202Q	SIDM00534	Colorectal Carcinoma	GDSC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.2222
p.R202Q	ACH-000965	Endometrial/Uterine Cancer	CCLE	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.2222
p.R202Q	ACH-000986	Colon/Colorectal Cancer	CCLE	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.2222
p.R202Q	RL95-2	endometrium	COSMIC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.2222
p.R202Q	HT-115	large intestine	COSMIC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation rewiring degron network	0.2222
p.R1658Q	TCGA-AN-A046	BRCA	TCGA	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.25
p.R1658Q	TCGA-AP-A0LM	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.25
p.R1658Q	TCGA-BS-A0UV	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.25
p.R1658Q	TCGA-E6-A1LX	UCEC	TCGA	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.25
p.R1658Q	DO1285	BRCA	ICGC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.25
p.R1658Q	DO43306	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.25
p.R1658Q	DO41020	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.25
p.R1658Q	DO42793	UCEC	ICGC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.25
p.T1542I	TCGA-AX-A1CE	UCEC	TCGA	VGSSS	DEG_SPOP_SBC_1	1545:1549	Mutation rewiring degron network	0.25
p.T1542I	DO42280	UCEC	ICGC	VGSSS	DEG_SPOP_SBC_1	1545:1549	Mutation rewiring degron network	0.25
p.I435V	TCGA-BA-A6DD	HNSC	TCGA	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1389
p.I435V	DO44452	HNSC	ICGC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1389
p.I1780N	TCGA-BR-6452	STAD	TCGA	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation rewiring degron network	0.0833
p.I1780N	DO38404	STAD	ICGC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation rewiring degron network	0.0833
p.S204N	TCGA-D1-A176	UCEC	TCGA	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation blocking phosphorylation signal	0.6111
p.S204N	DO43947	UCEC	ICGC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation blocking phosphorylation signal	0.6111
p.S419L	TCGA-D3-A2J6	SKCM	TCGA	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1944
p.S419L	DO37901	SKCM	ICGC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.1944
p.S1796L	TCGA-GN-A266	SKCM	TCGA	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation blocking phosphorylation signal	0.6944
p.S1796L	DO37432	SKCM	ICGC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation blocking phosphorylation signal	0.6944
p.A1158V	TCGA-GV-A3JZ	BLCA	TCGA	ALSST	DEG_SPOP_SBC_1	1158:1162	Mutation altering degron motif	0.5825
p.A1158V	DO773	BLCA	ICGC	ALSST	DEG_SPOP_SBC_1	1158:1162	Mutation altering degron motif	0.5825
p.E1539G	TCGA-KK-A8I9	PRAD	TCGA	VGSSS	DEG_SPOP_SBC_1	1545:1549	Mutation rewiring degron network	0.1667
p.E1539G	DO219323	PRAD	ICGC	VGSSS	DEG_SPOP_SBC_1	1545:1549	Mutation rewiring degron network	0.1667
p.F1170L	TCGA-QK-A8ZB	HNSC	TCGA	ALSST	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1111
p.F1170L	DO52100	HNSC	ICGC	ALSST	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.1111
p.K195R	DO233153	GACA	ICGC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation altering degron motif	0.7237
p.L421F	DO49140	PACA	ICGC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.25
p.I1155V	DO232761	PBCA	ICGC	ALSST	DEG_SPOP_SBC_1	1158:1162	Mutation rewiring degron network	0.25
p.K195Q	DO46933	RECA	ICGC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation altering degron motif	0.6944
p.E432K	SIDM00672	Hepatocellular Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM01117	Small Cell Lung Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM00878	Breast Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM00048	Non-Small Cell Lung Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM00844	Burkitt's Lymphoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM00863	Burkitt's Lymphoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM00628	Breast Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM01318	Hepatocellular Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM01710	Squamous Cell Lung Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.E432K	SIDM01752	Pancreatic Carcinoma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation rewiring degron network	0.2222
p.S427R	SIDM00340	Plasma Cell Myeloma	GDSC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.7427
p.S427R	ACH-000204	Myeloma	CCLE	VDTST	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.7427
p.S427R	LP-1	haematopoietic and lymphoid tissue	COSMIC	VDTST	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.7427
p.R1674Q	SIDM00135	Breast Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.0833
p.R1674Q	SIDM00632	Non-Cancerous	GDSC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.0833
p.R1674Q	SIDM00676	Bladder Carcinoma	GDSC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.0833
p.R1674Q	SIDM01154	T-Lymphoblastic Leukemia	GDSC	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation rewiring degron network	0.0833
p.S1792T	SIDM00845	Burkitt's Lymphoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM01090	Colorectal Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM01116	Non-Small Cell Lung Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM00746	Non-Small Cell Lung Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM00690	Head and Neck Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM00538	Esophageal Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM00694	Other Solid Cancers	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM00849	Kidney Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM00138	Non-Small Cell Lung Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM00863	Burkitt's Lymphoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM00956	Esophageal Squamous Cell Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.S1792T	SIDM01318	Hepatocellular Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation altering degron motif	0.6005
p.T1781N	SIDM00789	Colorectal Carcinoma	GDSC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation rewiring degron network	0.1111
p.T1781N	ACH-000997	Colon/Colorectal Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation rewiring degron network	0.1111
p.T1781N	ACH-001061	Colon/Colorectal Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation rewiring degron network	0.1111
p.T1781N	ACH-001091	Colon/Colorectal Cancer	CCLE	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation rewiring degron network	0.1111
p.T1781N	HCT-15	large intestine	COSMIC	PRTST	DEG_SPOP_SBC_1	1789:1793	Mutation rewiring degron network	0.1111
p.S1547F	SIDM00042	Pancreatic Carcinoma	GDSC	VGSSS	DEG_SPOP_SBC_1	1545:1549	Mutation altering degron motif	0.7982
p.S1547F	ACH-002186	Pancreatic Cancer	CCLE	VGSSS	DEG_SPOP_SBC_1	1545:1549	Mutation altering degron motif	0.7982
p.S1547F	PL4	pancreas	COSMIC	VGSSS	DEG_SPOP_SBC_1	1545:1549	Mutation altering degron motif	0.7982
p.R198K	SIDM01136	Pancreatic Carcinoma	GDSC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation altering degron motif	0.6126
p.R198K	ACH-000417	Pancreatic Cancer	CCLE	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation altering degron motif	0.6126
p.R198K	PANC-08-13	pancreas	COSMIC	HKENR	DEG_APCC_KENBOX_2	194:198	Mutation altering degron motif	0.6126
p.V1662L	ACH-000545	Bladder Cancer	CCLE	PVTTS	DEG_SPOP_SBC_1	1661:1665	Mutation altering degron motif	0.5654
p.D425H	ACH-000836	Head and Neck Cancer	CCLE	VDTST	DEG_SPOP_SBC_1	424:428	Mutation altering degron motif	0.6577

DegronMD: protein-targeted degradation, mutation and drug response to degrons

PHF3

UniProt ID: Q92576

Entrez ID: 23469

Protein name: PHD finger protein 3

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for PHF3 in