DegronMD

Uniprot ID: Q92576

Source protein: PHD finger protein 3

Source gene: PHF3

Class: DEG_APCC_KENBOX_2

Location: 194:198

E3 ligase: APC,CDC20,FZR1

DEGRON score: 0.7983

ASA_SCORE: 113.48

COIL: 0.627

CONS_SCORE: 0.3238

DSS_SCORE: 0.4594

HELIX: 0.2968

FCONS_SCORE: 0.981

RIG_SCORE: 0.7468

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S188P	TCGA-AA-A00N	COAD	TCGA	HKENR	DEG_APCC_KENBOX_2	0.1667
p.S188P	DO9876	COAD	ICGC	HKENR	DEG_APCC_KENBOX_2	0.1667
p.R202Q	TCGA-AN-A046	BRCA	TCGA	HKENR	DEG_APCC_KENBOX_2	0.2222
p.R202Q	DO1285	BRCA	ICGC	HKENR	DEG_APCC_KENBOX_2	0.2222
p.R202Q	SIDM01088	Endometrial Carcinoma	GDSC	HKENR	DEG_APCC_KENBOX_2	0.2222
p.R202Q	SIDM00534	Colorectal Carcinoma	GDSC	HKENR	DEG_APCC_KENBOX_2	0.2222
p.R202Q	ACH-000965	Endometrial/Uterine Cancer	CCLE	HKENR	DEG_APCC_KENBOX_2	0.2222
p.R202Q	ACH-000986	Colon/Colorectal Cancer	CCLE	HKENR	DEG_APCC_KENBOX_2	0.2222
p.R202Q	RL95-2	endometrium	COSMIC	HKENR	DEG_APCC_KENBOX_2	0.2222
p.R202Q	HT-115	large_intestine	COSMIC	HKENR	DEG_APCC_KENBOX_2	0.2222
p.S204N	TCGA-D1-A176	UCEC	TCGA	HKENR	DEG_APCC_KENBOX_2	0.6111
p.S204N	DO43947	UCEC	ICGC	HKENR	DEG_APCC_KENBOX_2	0.6111
p.K195R	DO233153	GACA	ICGC	HKENR	DEG_APCC_KENBOX_2	0.7237
p.K195Q	DO46933	RECA	ICGC	HKENR	DEG_APCC_KENBOX_2	0.6944
p.R198K	SIDM01136	Pancreatic Carcinoma	GDSC	HKENR	DEG_APCC_KENBOX_2	0.6126
p.R198K	ACH-000417	Pancreatic Cancer	CCLE	HKENR	DEG_APCC_KENBOX_2	0.6126
p.R198K	PANC-08-13	pancreas	COSMIC	HKENR	DEG_APCC_KENBOX_2	0.6126

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
Q92576	PHD finger protein 3	DEG_APCC_KENBOX_2	194:198	HKENR	APC,CDC20,FZR1	0.7983	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons