DegronMD: protein-targeted degradation, mutation and drug response to degrons
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Degron:
ALSST
Uniprot ID:
Q92576
Source protein:
PHD finger protein 3
Source gene:
PHF3
Class:
DEG_SPOP_SBC_1
Location:
1158:1162
E3 ligase:
SPOP
DEGRON score:
0.997
ASA_SCORE:
78.08
COIL:
0.7056
CONS_SCORE:
0.4075
DSS_SCORE:
0.4302
HELIX:
0.2844
FCONS_SCORE:
1.0026
RIG_SCORE:
0.7255
Degron related mutations and impact score
Mutation
Sample
Cancer
Dataset
Degron
Degron class
Impact score
p.A1158V
TCGA-GV-A3JZ
BLCA
TCGA
ALSST
DEG_SPOP_SBC_1
0.5825
p.A1158V
DO773
BLCA
ICGC
ALSST
DEG_SPOP_SBC_1
0.5825
p.F1170L
TCGA-QK-A8ZB
HNSC
TCGA
ALSST
DEG_SPOP_SBC_1
0.1111
p.F1170L
DO52100
HNSC
ICGC
ALSST
DEG_SPOP_SBC_1
0.1111
p.I1155V
DO232761
PBCA
ICGC
ALSST
DEG_SPOP_SBC_1
0.25
Drug responses associated with PHF3 mutations
Sample
Cancer
Mutation (In Degron?)
Dataset
Drug
IC50
All proteins holding degron of ALSST
Uniprot ID
Source protein
Degron class
Location
Hit
E3 ligase
Degron score
Detail
P13611
Versican core protein
DEG_SPOP_SBC_1
1048:1052
ALSST
SPOP
0.9809
More...
Q96GC6
Neurotrophin receptor-interacting factor homolog
DEG_SPOP_SBC_1
362:366
ALSST
SPOP
0.8364
More...
Q96T23
Remodeling and spacing factor 1
DEG_SPOP_SBC_1
555:559
ALSST
SPOP
0.6085
More...
Q9UBF2
Coatomer subunit gamma-2
DEG_SPOP_SBC_1
787:791
ALSST
SPOP
0.7115
More...
Q9Y5Y4
Prostaglandin D2 receptor 2
DEG_SPOP_SBC_1
389:393
ALSST
SPOP
0.9088
More...
Q7L1V2
Vacuolar fusion protein MON1 homolog B
DEG_SPOP_SBC_1
68:72
ALSST
SPOP
0.6448
More...
Q92576
PHD finger protein 3
DEG_SPOP_SBC_1
1158:1162
ALSST
SPOP
0.997
More...