DegronMD

Uniprot ID: Q7L1V2

Source protein: Vacuolar fusion protein MON1 homolog B

Source gene: MON1B

Class: DEG_SPOP_SBC_1

Location: 68:72

E3 ligase: SPOP

DEGRON score: 0.6448

ASA_SCORE: 67.12

COIL: 0.752

CONS_SCORE: 0.2673

DSS_SCORE: 0.8001

HELIX: 0.2114

FCONS_SCORE: 0.9366

RIG_SCORE: 0.582

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.R74W	TCGA-CK-4947	COAD	TCGA	ALSST	DEG_SPOP_SBC_1	0.2778
p.R74W	DO10076	COAD	ICGC	ALSST	DEG_SPOP_SBC_1	0.2778
p.E82Q	TCGA-D8-A13Y	BRCA	TCGA	ALSST	DEG_SPOP_SBC_1	0.0556
p.E82Q	DO4503	BRCA	ICGC	ALSST	DEG_SPOP_SBC_1	0.0556
p.P78L	TCGA-DF-A2KU	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	0.1667
p.P78L	TCGA-G4-6317	COAD	TCGA	ALSST	DEG_SPOP_SBC_1	0.1667
p.P78L	DO10100	COAD	ICGC	ALSST	DEG_SPOP_SBC_1	0.1667
p.P78L	DO223286	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	0.1667
p.P63L	TCGA-EY-A549	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	0.1944
p.P63L	DO48174	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	0.1944
p.V65M	DO9346	COAD	ICGC	ALSST	DEG_SPOP_SBC_1	0.25
p.A66T	DO227802	COCA	ICGC	ALSST	DEG_SPOP_SBC_1	0.7222
p.A68S	DO229037	LICA	ICGC	ALSST	DEG_SPOP_SBC_1	0.7588
p.R78Q	DO52409	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	0.1667
p.P60A	SIDM00882	Breast Carcinoma	GDSC	ALSST	DEG_SPOP_SBC_1	0.1111
p.S73F	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	ALSST	DEG_SPOP_SBC_1	0.3056
p.S73F	ACH-000845	Lung Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	0.3056
p.M67I	ACH-000516	Bone Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	0.3056
p.M67I	CAL-78	bone	COSMIC	ALSST	DEG_SPOP_SBC_1	0.3056
p.L72I	LOUCY	haematopoietic_and_lymphoid_tissue	COSMIC	ALSST	DEG_SPOP_SBC_1	0.7174
p.R81S	Sarc9371	bone	COSMIC	ALSST	DEG_SPOP_SBC_1	0.0833
p.R62H	451Lu	skin	COSMIC	ALSST	DEG_SPOP_SBC_1	0.1667
p.S59G	RL95-2	endometrium	COSMIC	ALSST	DEG_SPOP_SBC_1	0.5278
p.A61T	SNU-1040	large_intestine	COSMIC	ALSST	DEG_SPOP_SBC_1	0.5833

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
P13611	Versican core protein	DEG_SPOP_SBC_1	1048:1052	ALSST	SPOP	0.9809	More...
Q96GC6	Neurotrophin receptor-interacting factor homolog	DEG_SPOP_SBC_1	362:366	ALSST	SPOP	0.8364	More...
Q96T23	Remodeling and spacing factor 1	DEG_SPOP_SBC_1	555:559	ALSST	SPOP	0.6085	More...
Q9UBF2	Coatomer subunit gamma-2	DEG_SPOP_SBC_1	787:791	ALSST	SPOP	0.7115	More...
Q9Y5Y4	Prostaglandin D2 receptor 2	DEG_SPOP_SBC_1	389:393	ALSST	SPOP	0.9088	More...
Q7L1V2	Vacuolar fusion protein MON1 homolog B	DEG_SPOP_SBC_1	68:72	ALSST	SPOP	0.6448	More...
Q92576	PHD finger protein 3	DEG_SPOP_SBC_1	1158:1162	ALSST	SPOP	0.997	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons