DegronMD - Q7L1V2(MON1B)

Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.S84I	TCGA-85-8277	LUSC	TCGA	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.S84I	DO26719	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.P85L	TCGA-B5-A11E	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2222
p.P85L	DO41644	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2222
p.R74W	TCGA-CK-4947	COAD	TCGA	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2778
p.R74W	DO10076	COAD	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.2778
p.E82Q	TCGA-D8-A13Y	BRCA	TCGA	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0556
p.E82Q	TCGA-D8-A13Y	BRCA	TCGA	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1389
p.E82Q	DO4503	BRCA	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0556
p.E82Q	DO4503	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1389
p.P78L	TCGA-DF-A2KU	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1667
p.P78L	TCGA-G4-6317	COAD	TCGA	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1667
p.P78L	DO10100	COAD	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1667
p.P78L	DO223286	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1667
p.P63L	TCGA-EY-A549	UCEC	TCGA	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1944
p.P63L	DO48174	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1944
p.G98E	TCGA-W3-A828	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.G98E	DO51273	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.V65M	DO9346	COAD	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.25
p.A66T	DO227802	COCA	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation blocking phosphorylation signal	0.7222
p.S101G	DO222571	COCA	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1111
p.R99H	DO218693	GACA	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.R99H	ACH-001002	Skin Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.R99H	451Lu	skin	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.A68S	DO229037	LICA	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7588
p.R99L	DO45075	LINC	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1667
p.A102S	DO218920	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.R94C	DO228338	MALY	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.R94C	DO42256	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.R94C	ACH-002232	Lymphoma	CCLE	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.R94C	DG-75	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.I88V	DO232042	ORCA	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.P85S	DO229459	SKCA	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.2222
p.A98T	DO51749	STAD	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.A98T	DO41235	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.A98T	ACH-000999	Colon/Colorectal Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.A98T	SNU-1040	large intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1944
p.H103R	DO41752	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.R78Q	DO52409	UCEC	ICGC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1667
p.P60A	SIDM00882	Breast Carcinoma	GDSC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1111
p.P89H	SIDM01611	Endometrial Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7694
p.P89H	ACH-000996	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	89:93	Mutation altering degron motif	0.7694
p.S73F	SIDM01677	Non-Small Cell Lung Carcinoma	GDSC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.3056
p.S73F	ACH-000845	Lung Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.3056
p.M67I	ACH-000516	Bone Cancer	CCLE	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.3056
p.M67I	CAL-78	bone	COSMIC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.3056
p.S96G	ACH-000965	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.S96G	RL95-2	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.25
p.R94H	ACH-000978	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.R94H	EN	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.A102V	ACH-002336	Unknown	CCLE	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.R103C	DU-145	prostate	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.R103C	SNU-175	large intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0556
p.L72I	LOUCY	haematopoietic and lymphoid tissue	COSMIC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation altering degron motif	0.7174
p.V102M	P30-OHK	haematopoietic and lymphoid tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.V102M	SNU-175	large intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.0833
p.R81S	Sarc9371	bone	COSMIC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.0833
p.R81S	Sarc9371	bone	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.1111
p.R62H	451Lu	skin	COSMIC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation rewiring degron network	0.1667
p.P94R	NCI-H1436	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	89:93	Mutation rewiring degron network	0.3056
p.S59G	RL95-2	endometrium	COSMIC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation blocking phosphorylation signal	0.5278
p.A61T	SNU-1040	large intestine	COSMIC	ALSST	DEG_SPOP_SBC_1	68:72	Mutation blocking phosphorylation signal	0.5833

DegronMD: protein-targeted degradation, mutation and drug response to degrons

MON1B

UniProt ID: Q7L1V2

Entrez ID: 22879

Protein name: Vacuolar fusion protein MON1 homolog B (HSV-1 stimulation-related gene 1 protein) (HSV-I stimulating-related protein)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for MON1B in