DegronMD

Uniprot ID: Q7L1V2

Source protein: Vacuolar fusion protein MON1 homolog B

Source gene: MON1B

Class: DEG_SPOP_SBC_1

Location: 89:93

E3 ligase: SPOP

DEGRON score: 0.8405

ASA_SCORE: 85.2

COIL: 0.904

CONS_SCORE: 0.2447

DSS_SCORE: 0.811

HELIX: 0.068

FCONS_SCORE: 0.8594

RIG_SCORE: 0.5097

Degron related mutations and impact score

Mutation	Sample	Cancer	Dataset	Degron	Degron class	Impact score
p.S84I	TCGA-85-8277	LUSC	TCGA	PESSS	DEG_SPOP_SBC_1	0.1944
p.S84I	DO26719	LUSC	ICGC	PESSS	DEG_SPOP_SBC_1	0.1944
p.P85L	TCGA-B5-A11E	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	0.2222
p.P85L	DO41644	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	0.2222
p.E82Q	TCGA-D8-A13Y	BRCA	TCGA	PESSS	DEG_SPOP_SBC_1	0.1389
p.E82Q	DO4503	BRCA	ICGC	PESSS	DEG_SPOP_SBC_1	0.1389
p.G98E	TCGA-W3-A828	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	0.1944
p.G98E	DO51273	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	0.1944
p.S101G	DO222571	COCA	ICGC	PESSS	DEG_SPOP_SBC_1	0.1111
p.R99H	DO218693	GACA	ICGC	PESSS	DEG_SPOP_SBC_1	0.1667
p.R99H	ACH-001002	Skin Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	0.1667
p.R99H	451Lu	skin	COSMIC	PESSS	DEG_SPOP_SBC_1	0.1667
p.R99L	DO45075	LINC	ICGC	PESSS	DEG_SPOP_SBC_1	0.1667
p.A102S	DO218920	LUAD	ICGC	PESSS	DEG_SPOP_SBC_1	0.0833
p.R94C	DO228338	MALY	ICGC	PESSS	DEG_SPOP_SBC_1	0.3056
p.R94C	DO42256	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	0.3056
p.R94C	ACH-002232	Lymphoma	CCLE	PESSS	DEG_SPOP_SBC_1	0.3056
p.R94C	DG-75	haematopoietic_and_lymphoid_tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	0.3056
p.I88V	DO232042	ORCA	ICGC	PESSS	DEG_SPOP_SBC_1	0.3056
p.P85S	DO229459	SKCA	ICGC	PESSS	DEG_SPOP_SBC_1	0.2222
p.A98T	DO51749	STAD	ICGC	PESSS	DEG_SPOP_SBC_1	0.1944
p.A98T	DO41235	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	0.1944
p.A98T	ACH-000999	Colon/Colorectal Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	0.1944
p.A98T	SNU-1040	large_intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	0.1944
p.H103R	DO41752	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	0.0556
p.P89H	SIDM01611	Endometrial Carcinoma	GDSC	PESSS	DEG_SPOP_SBC_1	0.7694
p.P89H	ACH-000996	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	0.7694
p.S96G	ACH-000965	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	0.25
p.S96G	RL95-2	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	0.25
p.R94H	ACH-000978	Endometrial/Uterine Cancer	CCLE	PESSS	DEG_SPOP_SBC_1	0.3056
p.R94H	EN	endometrium	COSMIC	PESSS	DEG_SPOP_SBC_1	0.3056
p.A102V	ACH-002336	Unknown	CCLE	PESSS	DEG_SPOP_SBC_1	0.0833
p.R103C	DU-145	prostate	COSMIC	PESSS	DEG_SPOP_SBC_1	0.0556
p.R103C	SNU-175	large_intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	0.0556
p.V102M	P30-OHK	haematopoietic_and_lymphoid_tissue	COSMIC	PESSS	DEG_SPOP_SBC_1	0.0833
p.V102M	SNU-175	large_intestine	COSMIC	PESSS	DEG_SPOP_SBC_1	0.0833
p.R81S	Sarc9371	bone	COSMIC	PESSS	DEG_SPOP_SBC_1	0.1111
p.P94R	NCI-H1436	lung	COSMIC	PESSS	DEG_SPOP_SBC_1	0.3056

Uniprot ID	Source protein	Degron class	Location	Hit	E3 ligase	Degron score	Detail
A1L390	Pleckstrin homology domain-containing family G member 3	DEG_SPOP_SBC_1	866:870	PESSS	SPOP	0.9912	More...
P16112	Aggrecan core protein	DEG_SPOP_SBC_1	2097:2101	PESSS	SPOP	0.9834	More...
P20749	B-cell lymphoma 3 protein	DEG_SPOP_SBC_1	383:387	PESSS	SPOP	0.9491	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	216:220	PESSS	SPOP	0.8558	More...
P31270	Homeobox protein Hox-A11	DEG_SPOP_SBC_1	222:226	PESSS	SPOP	0.9936	More...
P49815	Tuberin	DEG_SPOP_SBC_1	1092:1096	PESSS	SPOP	0.9782	More...
P78426	Homeobox protein Nkx-6.1	DEG_SPOP_SBC_1	363:367	PESSS	SPOP	0.998	More...
Q03164	Histone-lysine N-methyltransferase 2A	DEG_SPOP_SBC_1	2867:2871	PESSS	SPOP	0.9742	More...
Q12918	Killer cell lectin-like receptor subfamily B member 1	DEG_SPOP_SBC_1	18:22	PESSS	SPOP	0.7957	More...
Q13501	Sequestosome-1	DEG_SPOP_SBC_1	273:277	PESSS	SPOP	0.8106	More...
Q14CM0	FERM and PDZ domain-containing protein 4	DEG_SPOP_SBC_1	901:905	PESSS	SPOP	0.9985	More...
Q5JY77	G-protein coupled receptor-associated sorting protein 1	DEG_SPOP_SBC_1	1137:1141	PESSS	SPOP	0.6247	More...
Q5TCQ9	Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3	DEG_SPOP_SBC_1	1446:1450	PESSS	SPOP	0.9938	More...
Q6UB98	Ankyrin repeat domain-containing protein 12	DEG_SPOP_SBC_1	592:596	PESSS	SPOP	0.9159	More...
Q6V0I7	Protocadherin Fat 4	DEG_SPOP_SBC_1	4836:4840	PESSS	SPOP	0.8987	More...
Q86XP3	ATP-dependent RNA helicase DDX42	DEG_SPOP_SBC_1	847:851	PESSS	SPOP	0.8412	More...
Q9BSD3	RAD9, HUS1, RAD1-interacting nuclear orphan protein 1	DEG_SPOP_SBC_1	160:164	PESSS	SPOP	0.9875	More...
Q9C0C2	182 kDa tankyrase-1-binding protein	DEG_SPOP_SBC_1	678:682	PESSS	SPOP	0.8779	More...
Q9H8Y8	Golgi reassembly-stacking protein 2	DEG_SPOP_SBC_1	372:376	PESSS	SPOP	0.9842	More...
Q9P275	Ubiquitin carboxyl-terminal hydrolase 36	DEG_SPOP_SBC_1	989:993	PESSS	SPOP	0.7219	More...
Q9Y6Q2	Stonin-1	DEG_SPOP_SBC_1	106:110	PESSS	SPOP	0.9755	More...
A6NI28	Rho GTPase-activating protein 42	DEG_SPOP_SBC_1	684:688	PESSS	SPOP	0.9972	More...
Q6T310	Ras-like protein family member 11A	DEG_SPOP_SBC_1	16:20	PESSS	SPOP	0.5145	More...
Q7L1V2	Vacuolar fusion protein MON1 homolog B	DEG_SPOP_SBC_1	89:93	PESSS	SPOP	0.8405	More...
Q8TD94	Krueppel-like factor 14	DEG_SPOP_SBC_1	141:145	PESSS	SPOP	0.99	More...
Q96JQ2	Calmin	DEG_SPOP_SBC_1	482:486	PESSS	SPOP	0.7996	More...
Q96S82	Ubiquitin-like protein 7	DEG_SPOP_SBC_1	282:286	PESSS	SPOP	0.92	More...
Q9Y2L6	FERM domain-containing protein 4B	DEG_SPOP_SBC_1	681:685	PESSS	SPOP	0.9815	More...
Q64ET8	Protein FRG2	DEG_SPOP_SBC_1	86:90	PESSS	SPOP	0.6784	More...
A6NGH7	Coiled-coil domain-containing protein 160	DEG_SPOP_SBC_1	29:33	PESSS	SPOP	0.9785	More...
A6NGY1	Protein FRG2-like-2	DEG_SPOP_SBC_1	87:91	PESSS	SPOP	0.8535	More...
Q3LI81	Keratin-associated protein 27-1	DEG_SPOP_SBC_1	168:172	PESSS	SPOP	0.6466	More...
Q8ND24	RING finger protein 214	DEG_SPOP_SBC_1	17:21	PESSS	SPOP	0.9867	More...
Q96QU4	Protein FRG2-like-1	DEG_SPOP_SBC_1	86:90	PESSS	SPOP	0.8637	More...

DegronMD: protein-targeted degradation, mutation and drug response to degrons

Degron: PESSS

Degron related mutations and impact score

Drug responses associated with MON1B mutations

All proteins holding degron of PESSS