DegronMD - Q12918(KLRB1)

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Mutation	Sample	Cancer	Dataset	Degron hit	Class	Location	Type	Impact score
p.I6V	TCGA-86-8074	LUAD	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.0833
p.I6V	DO25330	LUAD	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.0833
p.R28Q	TCGA-A5-A0G2	UCEC	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.1389
p.R28Q	TCGA-A5-A0G2	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.R28Q	TCGA-AX-A05S	UCEC	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.1389
p.R28Q	TCGA-AX-A05S	UCEC	TCGA	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.R28Q	DO43218	UCEC	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.1389
p.R28Q	DO43218	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.R28Q	DO41235	UCEC	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.1389
p.R28Q	DO41235	UCEC	ICGC	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.R28W	TCGA-AG-A002	READ	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.1389
p.R28W	TCGA-AG-A002	READ	TCGA	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.R28W	EFO-27	ovary	COSMIC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.1389
p.R28W	EFO-27	ovary	COSMIC	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.1667
p.S20C	TCGA-AG-A02N	READ	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation altering degron motif	0.643
p.S20C	TCGA-AG-A02N	READ	TCGA	PESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7541
p.S20C	DO37146	READ	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation altering degron motif	0.643
p.S20C	DO37146	READ	ICGC	PESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.7541
p.E19K	TCGA-EE-A2MI	SKCM	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation altering degron motif	0.591
p.E19K	TCGA-EE-A2MI	SKCM	TCGA	PESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.591
p.E19K	TCGA-FD-A5BS	BLCA	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation altering degron motif	0.591
p.E19K	TCGA-FD-A5BS	BLCA	TCGA	PESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.591
p.E19K	DO44047	BLCA	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation altering degron motif	0.591
p.E19K	DO44047	BLCA	ICGC	PESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.591
p.E19K	DO37531	SKCM	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation altering degron motif	0.591
p.E19K	DO37531	SKCM	ICGC	PESSS	DEG_SPOP_SBC_1	18:22	Mutation altering degron motif	0.591
p.E9D	TCGA-OR-A5J1	ACC	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.1667
p.E9D	TCGA-OR-A5J1	ACC	TCGA	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.0833
p.P23T	TCGA-QH-A6CV	LGG	TCGA	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.2778
p.P23T	TCGA-QH-A6CV	LGG	TCGA	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.3056
p.P23T	DO50169	LGG	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.2778
p.P23T	DO50169	LGG	ICGC	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.3056
p.A5V	DO223076	ESCA	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.0556
p.T14K	DO229045	LICA	ICGC	DSGPESS	DEG_SCF_TRCP1_1	15:21	Mutation rewiring degron network	0.3056
p.T14K	DO229045	LICA	ICGC	PESSS	DEG_SPOP_SBC_1	18:22	Mutation rewiring degron network	0.2222

Kaplan plot for KLRB1 in

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*NOTE: the Kaplan plots were collected from OncoLnc

DegronMD: protein-targeted degradation, mutation and drug response to degrons

KLRB1

UniProt ID: Q12918

Entrez ID: 3820

Protein name: Killer cell lectin-like receptor subfamily B member 1 (C-type lectin domain family 5 member B) (HNKR-P1a) (NKR-P1A) (Natural killer cell surface protein P1A) (CD antigen CD161)

External links: UniprotKB HGNC RefSeq COSMIC

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Kaplan plot for KLRB1 in